Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T89034 Target Info
Target Name Plasminogen (PLG)
Synonyms Plasmin
Target Type Successful Target
Gene Name PLG
Biochemical Class Peptidase
UniProt ID
PLMN_HUMAN
Ligand General Information  Top
Ligand Name Tranexamic acid Ligand Info
Canonical SMILES C1CC(CCC1CN)C(=O)O
InChI 1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)
InChIKey GYDJEQRTZSCIOI-UHFFFAOYSA-N
PubChem Compound ID 5526
Drug Binding Sites of Target  Top
PDB ID: 1CEB      THE STRUCTURE OF THE NON-COVALENT COMPLEX OF RECOMBINANT KRINGLE 1 DOMAIN OF HUMAN PLASMINOGEN WITH AMCHA (TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID)
Method X-ray diffraction Resolution 2.07 Å Mutation No [1]
PDB Sequence
ECKTGNGKNY
9
RGTMSKTKNG
19
ITCQKWSSTS
29
PHRPRFSPAT
39
HPSEGLEENY
49

CRNPDNDPQG
59
PWCYTTDPEK
69
RYDYCDILEC
79
Residue
Distance (Å)
ARG34
2.665
PHE35
3.746
ASP54
2.722
ASP56
3.052
TRP61
3.534
Residue
Distance (Å)
TYR63
2.507
ARG70
2.688
TYR71
3.500
TYR73
4.319
PDB ID: 1B2I      KRINGLE 2 DOMAIN OF HUMAN PLASMINOGEN: NMR SOLUTION STRUCTURE OF TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID (AMCHA) COMPLEX
Method Solution NMR Resolution N.A. Mutation Yes [2]
PDB Sequence
TSEECMHGSG
6
ENYDGKISKT
16
MSGLECQAWD
26
SQSPHAHGYI
37
PSKFPNKNLK
47

KNYCRNPDRE
57
LRPWCFTTDP
68
NKRWELCDIP
78
RCT
Residue
Distance (Å)
TYR36
1.902
PRO54
4.831
ASP55
1.955
GLU57
1.902
TRP62
2.471
Residue
Distance (Å)
PHE64
2.735
ARG71
1.827
TRP72
2.329
LEU74
4.261
References  Top
REF 1 Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid. Biochemistry. 1996 Feb 27;35(8):2567-76.
REF 2 Solution structure and dynamics of the plasminogen kringle 2-AMCHA complex: 3(1)-helix in homologous domains. Biochemistry. 1999 Nov 30;38(48):15741-55.

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