Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T88360 Target Info
Target Name Respiratory syncytial virus protein N (RSV N)
Synonyms RSV Protein N; RSV Nucleoprotein; RSV Nucleocapsid protein; N
Target Type Clinical trial Target
Gene Name RSV N
Biochemical Class Paramyxoviruses nucleocapsid
UniProt ID
NCAP_HRSVA
Ligand General Information  Top
Ligand Name L-phenylalanine Ligand Info
Canonical SMILES C1=CC=C(C=C1)CC(C(=O)O)N
InChI 1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
InChIKey COLNVLDHVKWLRT-QMMMGPOBSA-N
PubChem Compound ID 6140
Drug Binding Sites of Target  Top
PDB ID: 4UC8      N-terminal globular domain of the RSV Nucleoprotein in complex with C- terminal phenylalanine of the Phosphoprotein
Method X-ray diffraction Resolution 2.00 Å Mutation No [1]
PDB Sequence
SIDTPNYDVQ
41
KHINKLCGML
51
LITEDANHKF
61
TGLIGMLYAM
71
SRLGREDTIK
81

ILRDAGYHVK
91
ANGVDVTTHR
101
QDINGKEMKF
111
EVLTLASLTT
121
EIQINIEIES
131

RKSYKKMLKE
141
MGEVAPEYRH
151
DSPDCGMIIL
161
CIAALVITKL
171
AAGDRSGLTA
181

VIRRANNVLK
191
NEMKRYKGLL
201
PKDIANSFYE
211
VFEKHPHFID
221
VFVHFGIAQS
231

STKGGSRVEG
241
IFAGLFMNAY
251
GL
Residue
Distance (Å)
MET50
3.820
ILE53
4.066
GLU128
3.714
SER131
3.482
Residue
Distance (Å)
ARG132
3.540
TYR135
3.045
HIS151
3.321
PDB ID: 4UC9      N-terminal globular domain of the RSV Nucleoprotein in complex with C- terminal dipeptide of the Phosphoprotein
Method X-ray diffraction Resolution 2.40 Å Mutation No [1]
PDB Sequence
SIDTPNYDVQ
41
KHINKLCGML
51
LITEDANHKF
61
TGLIGMLYAM
71
SRLGREDTIK
81

ILRDAGYHVK
91
ANGVDVTTHR
101
QDINEMKFEV
113
LTLASLTTEI
123
QINIEIESRK
133

SYKKMLKEMG
143
EVAPEYRHDS
153
PDCGMIILCI
163
AALVITKLAA
173
GDRSGLTAVI
183

RRANNVLKNE
193
MKRYKGLLPK
203
DIANSFYEVF
213
EKHPHFIDVF
223
VHFGIAQSST
233

RGGSRVEGIF
243
AGLFMNAYG
Residue
Distance (Å)
LYS46
3.143
MET50
3.727
ILE53
3.952
GLU128
3.686
SER131
3.304
Residue
Distance (Å)
ARG132
3.333
TYR135
3.892
ARG150
3.941
HIS151
2.787
References  Top
REF 1 A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of Human Respiratory Syncytial Virus. J Virol. 2015 Nov;89(21):11129-43.

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