Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T88015 | Target Info | |||
| Target Name | COVID-19 3C-like protease (3CLpro) | ||||
| Synonyms | COVID-19 3CL-PRO; COVID-19 3CLp; COVID-19 nsp5 | ||||
| Gene Name | COVID-19 rep | ||||
| Biochemical Class | Coronaviruses polyprotein 1ab family | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | GC376\\(NC(=O)OCc1 | Ligand Info | |||
| Canonical SMILES | CC(C)CC(C(=O)NC(CC1CCNC1=O)C(O)S(=O)(=O)O)NC(=O)OCC2=CC=CC=C2 | ||||
| InChI | 1S/C21H31N3O8S/c1-13(2)10-16(24-21(28)32-12-14-6-4-3-5-7-14)19(26)23-17(20(27)33(29,30)31)11-15-8-9-22-18(15)25/h3-7,13,15-17,20,27H,8-12H2,1-2H3,(H,22,25)(H,23,26)(H,24,28)(H,29,30,31)/t15-,16-,17-,20-/m0/s1 | ||||
| InChIKey | BSPZFJDYQHDZNR-BOSXTWCSSA-N | ||||
| PubChem Compound ID | 137349627 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7CBT The crystal structure of SARS-CoV-2 main protease in complex with GC376 | ||||||
| Method | X-ray diffraction | Resolution | 2.35 Å | Mutation | No | [1] |
| PDB Sequence |
RKMAFPSGKV
13 EGCMVQVTCG23 TTTLNGLWLD33 DVVYCPRHVI43 CTSEDMLNPN53 YEDLLIRKSN 63 HNFLVQAGNV73 QLRVIGHSMQ83 NCVLKLKVDT93 ANPKTPKYKF103 VRIQPGQTFS 113 VLACYNGSPS123 GVYQCAMRPN133 FTIKGSFLNG143 SCGSVGFNID153 YDCVSFCYMH 163 HMELPTGVHA173 GTDLEGNFYG183 PFVDRQTAQA193 AGTDTTITVN203 VLAWLYAAVI 213 NGDRWFLNRF223 TTTLNDFNLV233 AMKYNYEPLT243 QDHVDILGPL253 SAQTGIAVLD 263 MCASLKELLQ273 NGMNGRTILG283 SALLEDEFTP293 FDVVRQCS
|
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THR26
4.735
LEU27
3.680
HIS41
2.319
CYS44
4.817
MET49
2.468
PRO52
4.536
TYR54
3.320
PHE140
2.355
LEU141
2.678
ASN142
2.291
GLY143
2.766
SER144
2.881
CYS145
1.767
|
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| PDB ID: 7CB7 1.7A resolution structure of SARS-CoV-2 main protease (Mpro) in complex with broad-spectrum coronavirus protease inhibitor GC376 | ||||||
| Method | X-ray diffraction | Resolution | 1.69 Å | Mutation | No | [2] |
| PDB Sequence |
GSGGGSGFRK
5 MAFPSGKVEG15 CMVQVTCGTT25 TLNGLWLDDV35 VYCPRHVICT45 SEDMLNPNYE 55 DLLIRKSNHN65 FLVQAGNVQL75 RVIGHSMQNC85 VLKLKVDTAN95 PKTPKYKFVR 105 IQPGQTFSVL115 ACYNGSPSGV125 YQCAMRPNFT135 IKGSFLNGSC145 GSVGFNIDYD 155 CVSFCYMHHM165 ELPTGVHAGT175 DLEGNFYGPF185 VDRQTAQAAG195 TDTTITVNVL 205 AWLYAAVING215 DRWFLNRFTT225 TLNDFNLVAM235 KYNYEPLTQD245 HVDILGPLSA 255 QTGIAVLDMC265 ASLKELLQNG275 MNGRTILGSA285 LLEDEFTPFD295 VVRQCSG |
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| PDB ID: 6WTT Crystals Structure of the SARS-CoV-2 (COVID-19) main protease with inhibitor GC-376 | ||||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | No | [3] |
| PDB Sequence |
SGFRKMAFPS
10 GKVEGCMVQV20 TCGTTTLNGL30 WLDDVVYCPR40 HVICTSEDML50 NPNYEDLLIR 60 KSNHNFLVQA70 GNVQLRVIGH80 SMQNCVLKLK90 VDTANPKTPK100 YKFVRIQPGQ 110 TFSVLACYNG120 SPSGVYQCAM130 RPNFTIKGSF140 LNGSCGSVGF150 NIDYDCVSFC 160 YMHHMELPTG170 VHAGTDLEGN180 FYGPFVDRQT190 AQAAGTDTTI200 TVNVLAWLYA 210 AVINGDRWFL220 NRFTTTLNDF230 NLVAMKYNYE240 PLTQDHVDIL250 GPLSAQTGIA 260 VLDMCASLKE270 LLQNGMNGRT280 ILGSALLEDE290 FTPFDVVRQC300 SG |
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|
|
LEU27
4.892
HIS41
3.583
CYS44
4.747
MET49
3.856
TYR54
4.385
PHE140
3.188
LEU141
3.739
ASN142
3.588
GLY143
3.471
SER144
3.506
CYS145
1.638
HIS163
2.661
|
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| PDB ID: 7K0E 1.90 A resolution structure of SARS-CoV-2 3CL protease in complex with deuterated GC376 | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [4] |
| PDB Sequence |
GFRKMAFPSG
11 KVEGCMVQVT21 CGTTTLNGLW31 LDDVVYCPRH41 VICTSEDMLN51 PNYEDLLIRK 61 SNHNFLVQAG71 NVQLRVIGHS81 MQNCVLKLKV91 DTANPKTPKY101 KFVRIQPGQT 111 FSVLACYNGS121 PSGVYQCAMR131 PNFTIKGSFL141 NGSCGSVGFN151 IDYDCVSFCY 161 MHHMELPTGV171 HAGTDLEGNF181 YGPFVDRQTA191 QAAGTDTTIT201 VNVLAWLYAA 211 VINGDRWFLN221 RFTTTLNDFN231 LVAMKYNYEP241 LTQDHVDILG251 PLSAQTGIAV 261 LDMCASLKEL271 LQNGMNGRTI281 LGSALLEDEF291 TPFDVVRQC
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .K36 or .K362 or .K363 or :3K36;style chemicals stick;color identity;select .A:41 or .A:49 or .A:54 or .A:140 or .A:141 or .A:142 or .A:143 or .A:144 or .A:145 or .A:163 or .A:164 or .A:165 or .A:166 or .A:172 or .A:186 or .A:187 or .A:188 or .A:189; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 7D1M CRYSTAL STRUCTURE OF THE SARS-CoV-2 MAIN PROTEASE COMPLEXED WITH GC376 | ||||||
| Method | X-ray diffraction | Resolution | 1.35 Å | Mutation | No | [5] |
| PDB Sequence |
GFRKMAFPSG
11 KVEGCMVQVT21 CGTTTLNGLW31 LDDVVYCPRH41 VICTSEDMLN51 PNYEDLLIRK 61 SNHNFLVQAG71 NVQLRVIGHS81 MQNCVLKLKV91 DTANPKTPKY101 KFVRIQPGQT 111 FSVLACYNGS121 PSGVYQCAMR131 PNFTIKGSFL141 NGSCGSVGFN151 IDYDCVSFCY 161 MHHMELPTGV171 HAGTDLEGNF181 YGPFVDRQTA191 QAAGTDTTIT201 VNVLAWLYAA 211 VINGDRWFLN221 RFTTTLNDFN231 LVAMKYNYEP241 LTQDHVDILG251 PLSAQTGIAV 261 LDMCASLKEL271 LQNGMNGRTI281 LGSALLEDEF291 TPFDVVRQCS301 GVTFQ |
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .K36 or .K362 or .K363 or :3K36;style chemicals stick;color identity;select .A:41 or .A:49 or .A:54 or .A:140 or .A:141 or .A:142 or .A:143 or .A:144 or .A:145 or .A:163 or .A:164 or .A:165 or .A:166 or .A:167 or .A:168 or .A:172 or .A:187 or .A:188 or .A:189 or .A:190 or .A:191; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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HIS41
3.725
MET49
3.812
TYR54
4.307
PHE140
3.205
LEU141
3.921
ASN142
3.226
GLY143
3.412
SER144
3.398
CYS145
1.657
HIS163
2.710
HIS164
2.934
|
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| PDB ID: 8D4M Crystal Structure of SARS-CoV-2 Main Protease (Mpro) S144A Mutant in Complex with Inhibitor GC376 | ||||||
| Method | X-ray diffraction | Resolution | 1.81 Å | Mutation | Yes | [6] |
| PDB Sequence |
SGFRKMAFPS
10 GKVEGCMVQV20 TCGTTTLNGL30 WLDDVVYCPR40 HVICTSEDML50 NPNYEDLLIR 60 KSNHNFLVQA70 GNVQLRVIGH80 SMQNCVLKLK90 VDTANPKTPK100 YKFVRIQPGQ 110 TFSVLACYNG120 SPSGVYQCAM130 RPNFTIKGSF140 LNGACGSVGF150 NIDYDCVSFC 160 YMHHMELPTG170 VHAGTDLEGN180 FYGPFVDRQT190 AQAAGTDTTI200 TVNVLAWLYA 210 AVINGDRWFL220 NRFTTTLNDF230 NLVAMKYNYE240 PLTQDHVDIL250 GPLSAQTGIA 260 VLDMCASLKE270 LLQNGMNGRT280 ILGSALLEDE290 FTPFDVVRQC300 SGVTF |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .K36 or .K362 or .K363 or :3K36;style chemicals stick;color identity;select .A:41 or .A:49 or .A:54 or .A:140 or .A:141 or .A:142 or .A:143 or .A:144 or .A:145 or .A:163 or .A:164 or .A:165 or .A:166 or .A:172 or .A:187 or .A:188 or .A:189; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 8D4K Crystal Structure of SARS-CoV-2 Main Protease (Mpro) H172Y Mutant in Complex with Inhibitor GC376 | ||||||
| Method | X-ray diffraction | Resolution | 1.89 Å | Mutation | Yes | [6] |
| PDB Sequence |
GFRKMAFPSG
11 KVEGCMVQVT21 CGTTTLNGLW31 LDDVVYCPRH41 VICTSEDMLN51 PNYEDLLIRK 61 SNHNFLVQAG71 NVQLRVIGHS81 MQNCVLKLKV91 DTANPKTPKY101 KFVRIQPGQT 111 FSVLACYNGS121 PSGVYQCAMR131 PNFTIKGSFL141 NGSCGSVGFN151 IDYDCVSFCY 161 MHHMELPTGV171 YAGTDLEGNF181 YGPFVDRQTA191 QAAGTDTTIT201 VNVLAWLYAA 211 VINGDRWFLN221 RFTTTLNDFN231 LVAMKYNYEP241 LTQDHVDILG251 PLSAQTGIAV 261 LDMCASLKEL271 LQNGMNGRTI281 LGSALLEDEF291 TPFDVVRQCS301 GVTF |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .K36 or .K362 or .K363 or :3K36;style chemicals stick;color identity;select .A:27 or .A:41 or .A:49 or .A:54 or .A:140 or .A:141 or .A:142 or .A:143 or .A:144 or .A:145 or .A:163 or .A:164 or .A:165 or .A:166 or .A:172 or .A:187 or .A:188 or .A:189; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 6WTJ Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [7] |
| PDB Sequence |
SGFRKMAFPS
10 GKVEGCMVQV20 TCGTTTLNGL30 WLDDVVYCPR40 HVICTSEDML50 NPNYEDLLIR 60 KSNHNFLVQA70 GNVQLRVIGH80 SMQNCVLKLK90 VDTANPKTPK100 YKFVRIQPGQ 110 TFSVLACYNG120 SPSGVYQCAM130 RPNFTIKGSF140 LNGSCGSVGF150 NIDYDCVSFC 160 YMHHMELPTG170 VHAGTDLEGN180 FYGPFVDRQT190 AQAAGTDTTI200 TVNVLAWLYA 210 AVINGDRWFL220 NRFTTTLNDF230 NLVAMKYNYE240 PLTQDHVDIL250 GPLSAQTGIA 260 VLDMCASLKE270 LLQNGMNGRT280 ILGSALLEDE290 FTPFDVVRQC300 SGVTFQ |
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .K36 or .K362 or .K363 or :3K36;style chemicals stick;color identity;select .A:41 or .A:49 or .A:54 or .A:140 or .A:141 or .A:142 or .A:143 or .A:144 or .A:145 or .A:163 or .A:164 or .A:165 or .A:166 or .A:172 or .A:187 or .A:188 or .A:189; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 7C6U Crystal structure of SARS-CoV-2 complexed with GC376 | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [5] |
| PDB Sequence |
SGFRKMAFPS
10 GKVEGCMVQV20 TCGTTTLNGL30 WLDDVVYCPR40 HVICTSEDML50 NPNYEDLLIR 60 KSNHNFLVQA70 GNVQLRVIGH80 SMQNCVLKLK90 VDTANPKTPK100 YKFVRIQPGQ 110 TFSVLACYNG120 SPSGVYQCAM130 RPNFTIKGSF140 LNGSCGSVGF150 NIDYDCVSFC 160 YMHHMELPTG170 VHAGTDLEGN180 FYGPFVDRQT190 AQAAGTDTTI200 TVNVLAWLYA 210 AVINGDRWFL220 NRFTTTLNDF230 NLVAMKYNYE240 PLTQDHVDIL250 GPLSAQTGIA 260 VLDMCASLKE270 LLQNGMNGRT280 ILGSALLEDE290 FTPFDVVRQC300 S |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .K36 or .K362 or .K363 or :3K36;style chemicals stick;color identity;select .A:27 or .A:41 or .A:49 or .A:54 or .A:140 or .A:141 or .A:142 or .A:143 or .A:144 or .A:145 or .A:163 or .A:164 or .A:165 or .A:166 or .A:172 or .A:186 or .A:187 or .A:188 or .A:189; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 7UKK Room-temperature X-ray structure of SARS-CoV-2 main protease in complex with GC-376 | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [8] |
| PDB Sequence |
SGFRKMAFPS
10 GKVEGCMVQV20 TCGTTTLNGL30 WLDDVVYCPR40 HVICTSEDML50 NPNYEDLLIR 60 KSNHNFLVQA70 GNVQLRVIGH80 SMQNCVLKLK90 VDTANPKTPK100 YKFVRIQPGQ 110 TFSVLACYNG120 SPSGVYQCAM130 RPNFTIKGSF140 LNGSCGSVGF150 NIDYDCVSFC 160 YMHHMELPTG170 VHAGTDLEGN180 FYGPFVDRQT190 AQAAGTDTTI200 TVNVLAWLYA 210 AVINGDRWFL220 NRFTTTLNDF230 NLVAMKYNYE240 PLTQDHVDIL250 GPLSAQTGIA 260 VLDMCASLKE270 LLQNGMNGRT280 ILGSALLEDE290 FTPFDVVRQC300 SGVTFQ |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .K36 or .K362 or .K363 or :3K36;style chemicals stick;color identity;select .A:41 or .A:49 or .A:54 or .A:140 or .A:141 or .A:142 or .A:143 or .A:144 or .A:145 or .A:163 or .A:164 or .A:165 or .A:166 or .A:167 or .A:168 or .A:172 or .A:187 or .A:188 or .A:189 or .A:190 or .A:191; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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HIS41
3.614
MET49
3.749
TYR54
3.904
PHE140
3.453
LEU141
3.945
ASN142
3.754
GLY143
3.303
SER144
3.307
CYS145
1.865
HIS163
2.510
HIS164
3.086
|
|||||
| PDB ID: 8DD1 SARS-CoV-2 Main Protease (Mpro) H164N Mutant in Complex with Inhibitor GC376 | ||||||
| Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | Yes | [6] |
| PDB Sequence |
SGFRKMAFPS
10 GKVEGCMVQV20 TCGTTTLNGL30 WLDDVVYCPR40 HVICTSEDML50 NPNYEDLLIR 60 KSNHNFLVQA70 GNVQLRVIGH80 SMQNCVLKLK90 VDTANPKTPK100 YKFVRIQPGQ 110 TFSVLACYNG120 SPSGVYQCAM130 RPNFTIKGSF140 LNGSCGSVGF150 NIDYDCVSFC 160 YMHNMELPTG170 VHAGTDLEGN180 FYGPFVDRQT190 AQAAGTDTTI200 TVNVLAWLYA 210 AVINGDRWFL220 NRFTTTLNDF230 NLVAMKYNYE240 PLTQDHVDIL250 GPLSAQTGIA 260 VLDMCASLKE270 LLQNGMNGRT280 ILGSALLEDE290 FTPFDVVRQC300 SGVT |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .K36 or .K362 or .K363 or :3K36;style chemicals stick;color identity;select .A:41 or .A:49 or .A:54 or .A:140 or .A:141 or .A:142 or .A:143 or .A:144 or .A:145 or .A:163 or .A:164 or .A:165 or .A:166 or .A:172 or .A:187 or .A:188 or .A:189; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 7C8U The crystal structure of COVID-19 main protease in complex with GC376 | ||||||
| Method | X-ray diffraction | Resolution | 2.35 Å | Mutation | No | [9] |
| PDB Sequence |
FRKMAFPSGK
12 VEGCMVQVTC22 GTTTLNGLWL32 DDVVYCPRHV42 ICTSEDMLNP52 NYEDLLIRKS 62 NHNFLVQAGN72 VQLRVIGHSM82 QNCVLKLKVD92 TANPKTPKYK102 FVRIQPGQTF 112 SVLACYNGSP122 SGVYQCAMRP132 NFTIKGSFLN142 GSCGSVGFNI152 DYDCVSFCYM 162 HHMELPTGVH172 AGTDLEGNFY182 GPFVDRQTAQ192 AAGTDTTITV202 NVLAWLYAAV 212 INGDRWFLNR222 FTTTLNDFNL232 VAMKYNYEPL242 TQDHVDILGP252 LSAQTGIAVL 262 DMCASLKELL272 QNGMNGRTIL282 GSALLEDEFT292 PFDVVRQCSG302 |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .K36 or .K362 or .K363 or :3K36;style chemicals stick;color identity;select .A:41 or .A:49 or .A:54 or .A:140 or .A:141 or .A:142 or .A:143 or .A:144 or .A:145 or .A:163 or .A:164 or .A:165 or .A:166 or .A:172 or .A:186 or .A:187 or .A:188 or .A:189; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 8DDM Crystal Structure of SARS-CoV-2 Main Protease (Mpro) E166R Mutant in Complex with Inhibitor GC376 | ||||||
| Method | X-ray diffraction | Resolution | 2.78 Å | Mutation | Yes | [10] |
| PDB Sequence |
SGFRKMAFPS
10 GKVEGCMVQV20 TCGTTTLNGL30 WLDDVVYCPR40 HVICTSEDML50 NPNYEDLLIR 60 KSNHNFLVQA70 GNVQLRVIGH80 SMQNCVLKLK90 VDTANPKTPK100 YKFVRIQPGQ 110 TFSVLACYNG120 SPSGVYQCAM130 RPNFTIKGSF140 LNGSCGSVGF150 NIDYDCVSFC 160 YMHHMRLPTG170 VHAGTDLEGN180 FYGPFVDRQT190 AQAAGTDTTI200 TVNVLAWLYA 210 AVINGDRWFL220 NRFTTTLNDF230 NLVAMKYNYE240 PLTQDHVDIL250 GPLSAQTGIA 260 VLDMCASLKE270 LLQNGMNGRT280 ILGSALLEDE290 FTPFDVVRQC300 SGVTF |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .K36 or .K362 or .K363 or :3K36;style chemicals stick;color identity;select .A:41 or .A:49 or .A:54 or .A:140 or .A:141 or .A:142 or .A:143 or .A:144 or .A:145 or .A:163 or .A:164 or .A:165 or .A:166 or .A:172 or .A:187 or .A:188 or .A:189; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| PDB ID: 7TGR Structure of SARS-CoV-2 main protease in complex with GC376 | ||||||
| Method | X-ray diffraction | Resolution | 1.68 Å | Mutation | No | [11] |
| PDB Sequence |
SGFRKMAFPS
10 GKVEGCMVQV20 TCGTTTLNGL30 WLDDVVYCPR40 HVICTSEDML50 NPNYEDLLIR 60 KSNHNFLVQA70 GNVQLRVIGH80 SMQNCVLKLK90 VDTANPKTPK100 YKFVRIQPGQ 110 TFSVLACYNG120 SPSGVYQCAM130 RPNFTIKGSF140 LNGSCGSVGF150 NIDYDCVSFC 160 YMHHMELPTG170 VHAGTDLEGN180 FYGPFVDRQT190 AQAAGTDTTI200 TVNVLAWLYA 210 AVINGDRWFL220 NRFTTTLNDF230 NLVAMKYNYE240 PLTQDHVDIL250 GPLSAQTGIA 260 VLDMCASLKE270 LLQNGMNGRT280 ILGSALLEDE290 FTPFDVVRQC300 SGVT |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .K36 or .K362 or .K363 or :3K36;style chemicals stick;color identity;select .A:41 or .A:49 or .A:54 or .A:140 or .A:141 or .A:142 or .A:143 or .A:144 or .A:145 or .A:163 or .A:164 or .A:165 or .A:166 or .A:172 or .A:187 or .A:188 or .A:189; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract. Emerg Microbes Infect. 2021 Dec;10(1):481-492. | ||||
| REF 2 | Structural basis of SARS-CoV-2 main protease inhibition by a broad-spectrum anti-coronaviral drug. Am J Cancer Res. 2020 Aug 1;10(8):2535-2545. eCollection 2020. | ||||
| REF 3 | Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. Cell Res. 2020 Aug;30(8):678-692. | ||||
| REF 4 | Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2101555118. | ||||
| REF 5 | Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease. Nat Commun. 2020 Sep 4;11(1):4417. | ||||
| REF 6 | Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir. bioRxiv. 2022 Sep 6:2022.06.28.497978. | ||||
| REF 7 | Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nat Commun. 2020 Aug 27;11(1):4282. | ||||
| REF 8 | Autoprocessing and oxyanion loop reorganization upon GC373 and nirmatrelvir binding of monomeric SARS-CoV-2 main protease catalytic domain. Commun Biol. 2022 Sep 16;5(1):976. | ||||
| REF 9 | The crystal structure of COVID-19 main protease in complex with GC376 | ||||
| REF 10 | A yeast-based system to study SARS-CoV-2 M (pro) structure and to identify nirmatrelvir resistant mutations. bioRxiv. 2022 Aug 8:2022.08.06.503039. | ||||
| REF 11 | Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 M(pro)/3CL(pro) in Living Cells. mBio. 2022 Jun 28;13(3):e0078422. | ||||
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