Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T87831 | Target Info | |||
| Target Name | N-formyl peptide receptor (FPR1) | ||||
| Synonyms | N-formylpeptide chemoattractant receptor; FPR1; FPR | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | FPR1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Cholesterol | Ligand Info | |||
| Canonical SMILES | CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C | ||||
| InChI | 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 | ||||
| InChIKey | HVYWMOMLDIMFJA-DPAQBDIFSA-N | ||||
| PubChem Compound ID | 5997 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7VFX The structure of Formyl Peptide Receptor 1 in complex with Gi and peptide agonist fMIFL | ||||||
| Method | Electron microscopy | Resolution | 2.80 Å | Mutation | No | [1] |
| PDB Sequence |
YLFLDIITYL
31 VFAVTFVLGV41 LGNGLVIWVA51 GFRMTHTVTT61 ISYLNLAVAD71 FCFTSTLPFF 81 MVRKAMGGHW91 PFGWFLCKFV101 FTIVDINLFG111 SVFLIALIAL121 DRCVCVLHPV 131 WTQNHRTVSL141 AKKVIIGPWV151 MALLLTLPVI161 IRVTTVPGKT171 GTVACTFNFS 181 PWTNDPKERI191 NVAVAMLTVR201 GIIRFIIGFS211 APMSIVAVSY221 GLIATKIHKQ 231 GLIKSSRPLR241 VLSFVAAAFF251 LCWSPYQVVA261 LIATVRIREL271 LQGMYKEIGI 281 AVDVTSALAF291 FNSCLNPMLY301 VFMGQDFRER311 LIHAL
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ILE48
4.273
GLY52
3.607
PHE53
3.980
HIS57
3.562
ILE62
3.773
LEU65
3.657
ASN66
3.535
VAL69
3.655
PHE72
4.044
CYS73
3.809
SER76
4.083
ILE104
4.052
ILE107
4.106
ASN108
4.739
PHE114
3.830
ALA117
3.885
|
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| PDB ID: 7EUO The structure of formyl peptide receptor 1 in complex with Gi and peptide agonist fMLF | ||||||
| Method | Electron microscopy | Resolution | 2.90 Å | Mutation | No | [1] |
| PDB Sequence |
YLFLDIITYL
31 VFAVTFVLGV41 LGNGLVIWVA51 GFRMTHTVTT61 ISYLNLAVAD71 FCFTSTLPFF 81 MVRKAMGGHW91 PFGWFLCKFV101 FTIVDINLFG111 SVFLIALIAL121 DRCVCVLHPV 131 WTQNHRTVSL141 AKKVIIGPWV151 MALLLTLPVI161 IRVTTVPGKT171 GTVACTFNFS 181 PWTNDPKERI191 NVAVAMLTVR201 GIIRFIIGFS211 APMSIVAVSY221 GLIATKIHKQ 231 GLIKSSRPLR241 VLSFVAAAFF251 LCWSPYQVVA261 LIATVRIREL271 LQGMYKEIGI 281 AVDVTSALAF291 FNSCLNPMLY301 VFMGQDFRER311 LIHAL
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns. Nat Commun. 2022 Sep 5;13(1):5232. | ||||
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