Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T87686 | Target Info | |||
| Target Name | Histone-lysine N-methyltransferase (HLNM) | ||||
| Synonyms | Lysine N-methyltransferase 4; KMT4; KIAA1814; Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone H3-K79 methyltransferase; H3-K79-HMTase; DOT1-like protein | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | DOT1L | ||||
| Biochemical Class | Methyltransferase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Norleucine | Ligand Info | |||
| Canonical SMILES | CCCCC(C(=O)O)N | ||||
| InChI | 1S/C6H13NO2/c1-2-3-4-5(7)6(8)9/h5H,2-4,7H2,1H3,(H,8,9)/t5-/m0/s1 | ||||
| InChIKey | LRQKBLKVPFOOQJ-YFKPBYRVSA-N | ||||
| PubChem Compound ID | 21236 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7XCR Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 1:1 complex | ||||||
| Method | Electron microscopy | Resolution | 2.57 Å | Mutation | No | [1] |
| PDB Sequence |
LELRLKSPVG
14 AEPAVYPWPL24 PVYDKHHDAA34 HEIIETIRWV44 CEEIPDLKLA54 MENYVLIDYD 64 TKSFESMQRL74 CDKYNRAIDS84 IHQLWKGTTQ94 PMKLNTRPST104 GLLRHILQQV 114 YNHSVTDPEK124 LNNYEPFSPE134 VYGETSFDLV144 AQMIDEIKMT154 DDDLFVDLGS 164 GVGQVVLQVA174 AATNCKHHYG184 VEKADIPAKY194 AETMDREFRK204 WMKWYGKKHA 214 EYTLERGDFL224 SEEWRERIAN234 TSVIFVNNFA244 FGPEVDHQLK254 ERFANMKEGG 264 RIVSSKPFAP274 LNFRINSRNL284 SDIGTIMRVV294 ELSPLKGSVS304 WTGKPVSYYL 314 HTIDRTILEN324 YFSSLKNP
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| PDB ID: 7XCT Cryo-EM structure of Dot1L and H2BK34ub-H3K79Nle nucleosome 2:1 complex | ||||||
| Method | Electron microscopy | Resolution | 2.72 Å | Mutation | No | [1] |
| PDB Sequence |
LELRLKSPVG
14 AEPAVYPWPL24 PVYDKHHDAA34 HEIIETIRWV44 CEEIPDLKLA54 MENYVLIDYD 64 TKSFESMQRL74 CDKYNRAIDS84 IHQLWKGTTQ94 PMKLNTRPST104 GLLRHILQQV 114 YNHSVTDPEK124 LNNYEPFSPE134 VYGETSFDLV144 AQMIDEIKMT154 DDDLFVDLGS 164 GVGQVVLQVA174 AATNCKHHYG184 VEKADIPAKY194 AETMDREFRK204 WMKWYGKKHA 214 EYTLERGDFL224 SEEWRERIAN234 TSVIFVNNFA244 FGPEVDHQLK254 ERFANMKEGG 264 RIVSSKPFAP274 LNFRINSRNL284 SDIGTIMRVV294 ELSPLKGSVS304 WTGKPVSYYL 314 HTIDRTILEN324 YFSSLK
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity. Nat Chem Biol. 2022 Sep;18(9):972-980. | ||||
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