Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T87109 | Target Info | |||
| Target Name | Casein kinase I delta (CSNK1D) | ||||
| Synonyms | Tau-protein kinase CSNK1D; HCKID; Casein kinase I isoform delta; CKId; CKI-delta | ||||
| Target Type | Preclinical Target | ||||
| Gene Name | CSNK1D | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Mesotartaric acid | Ligand Info | |||
| Canonical SMILES | C(C(C(=O)O)O)(C(=O)O)O | ||||
| InChI | 1S/C4H6O6/c5-1(3(7)8)2(6)4(9)10/h1-2,5-6H,(H,7,8)(H,9,10)/t1-,2+ | ||||
| InChIKey | FEWJPZIEWOKRBE-XIXRPRMCSA-N | ||||
| PubChem Compound ID | 447315 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 5IH4 Human Casein Kinase 1 isoform delta apo (kinase domain) | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [1] |
| PDB Sequence |
ELRVGNRYRL
11 GRKIGSGSFG21 DIYLGTDIAA31 GEEVAIKLEC41 VKTKHPQLHI51 ESKIYKMMQG 61 GVGIPTIRWC71 GAEGDYNVMV81 MELLGPSLED91 LFNFCSRKFS101 LKTVLLLADQ 111 MISRIEYIHS121 KNFIHRDVKP131 DNFLMGLGKK141 GNLVYIIDFG151 LAKKYRDART 161 HQHIPYRENK171 NLTGTARYAS181 INTHLGIEQS191 RRDDLESLGY201 VLMYFNLGSL 211 PWQGLQKYER227 ISEKKMSTPI237 EVLCKGYPSE247 FATYLNFCRS257 LRFDDKPDYS 267 YLRQLFRNLF277 HRQGFSYDYV287 FDWNMLK
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| PDB ID: 5IH5 Human Casein Kinase 1 isoform delta (kinase domain) in complex with Epiblastin A | ||||||
| Method | X-ray diffraction | Resolution | 2.25 Å | Mutation | No | [1] |
| PDB Sequence |
ELRVGNRYRL
11 GRKIGSGSFG21 DIYLGTDIAA31 GEEVAIKLEC41 VKTKHPQLHI51 ESKIYKMMQG 61 GVGIPTIRWC71 GAEGDYNVMV81 MELLGPSLED91 LFNFCSRKFS101 LKTVLLLADQ 111 MISRIEYIHS121 KNFIHRDVKP131 DNFLMGLGKK141 GNLVYIIDFG151 LAKKYRDART 161 HQHIPYRENK171 NLTGTARYAS181 INTHLGIEQS191 RRDDLESLGY201 VLMYFNLGSL 211 PWQGLQKYER227 ISEKKMSTPI237 EVLCKGYPSE247 FATYLNFCRS257 LRFDDKPDYS 267 YLRQLFRNLF277 HRQGFSYDYV287 FDWNMLK
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| PDB ID: 5IH6 Human Casein Kinase 1 isoform delta (kinase domain) in complex with Epiblastin A derivative | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [1] |
| PDB Sequence |
ELRVGNRYRL
11 GRKIGSGSFG21 DIYLGTDIAA31 GEEVAIKLEC41 VKTKHPQLHI51 ESKIYKMMQG 61 GVGIPTIRWC71 GAEGDYNVMV81 MELLGPSLED91 LFNFCSRKFS101 LKTVLLLADQ 111 MISRIEYIHS121 KNFIHRDVKP131 DNFLMGLGKK141 GNLVYIIDFG151 LAKKYRDART 161 HQHIPYRENK171 NLTGTARYAS181 INTHLGIEQS191 RRDDLESLGY201 VLMYFNLGSL 211 PWQGLQKYER227 ISEKKMSTPI237 EVLCKGYPSE247 FATYLNFCRS257 LRFDDKPDYS 267 YLRQLFRNLF277 HRQGFSYDYV287 FDWNML
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. Cell Chem Biol. 2016 Apr 21;23(4):494-507. | ||||
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