Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T87109 | Target Info | |||
| Target Name | Casein kinase I delta (CSNK1D) | ||||
| Synonyms | Tau-protein kinase CSNK1D; HCKID; Casein kinase I isoform delta; CKId; CKI-delta | ||||
| Target Type | Preclinical Target | ||||
| Gene Name | CSNK1D | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | L-serine-O-phosphate | Ligand Info | |||
| Canonical SMILES | C(C(C(=O)O)N)OP(=O)(O)O | ||||
| InChI | 1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 | ||||
| InChIKey | BZQFBWGGLXLEPQ-REOHCLBHSA-N | ||||
| PubChem Compound ID | 68841 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6RU8 Crystal structure of Casein Kinase I delta (CK1d) in complex with triple phosphorylated p63 PAD3P peptide | ||||||
| Method | X-ray diffraction | Resolution | 1.92 Å | Mutation | No | [1] |
| PDB Sequence |
ELRVGNRYRL
11 GRKIGSGSFG21 DIYLGTDIAA31 GEEVAIKLEC41 VKTKHPQLHI51 ESKIYKMMQG 61 GVGIPTIRWC71 GAEGDYNVMV81 MELLGPSLED91 LFNFCSRKFS101 LKTVLLLADQ 111 MISRIEYIHS121 KNFIHRDVKP131 DNFLMGLGKK141 GNLVYIIDFG151 LAKKYRDART 161 HQHIPYRENK171 NLTGTARYAS181 INTHLGIEQS191 RRDDLESLGY201 VLMYFNLGSL 211 PWQGLKAATK221 RQKYERISEK231 KMSTPIEVLC241 KGYPSEFATY251 LNFCRSLRFD 261 DKPDYSYLRQ271 LFRNLFHRQG281 FSYDYVFDWN291 MLK
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| PDB ID: 6RU6 Crystal structure of Casein Kinase I delta (CK1d) in complex with monophosphorylated p63 PAD1P peptide | ||||||
| Method | X-ray diffraction | Resolution | 2.05 Å | Mutation | No | [1] |
| PDB Sequence |
LRVGNRYRLG
12 RKIGSDIYLG26 TDIAAGEEVA36 IKLECVKTKH46 PQLHIESKIY56 KMMQGGVGIP 66 TIRWCGAEGD76 YNVMVMELLG86 PSLEDLFNFC96 SRKFSLKTVL106 LLADQMISRI 116 EYIHSKNFIH126 RDVKPDNFLM136 GLGKKGNLVY146 IIDFGLAKKY156 RDARTHQHIP 166 YRENKNLTGT176 ARYASINTHL186 GIEQSRRDDL196 ESLGYVLMYF206 NLGSLPWQGL 216 KAATKRQKYE226 RISEKKMSTP236 IEVLCKGYPS246 EFATYLNFCR256 SLRFDDKPDY 266 SYLRQLFRNL276 FHRQGFSYDY286 VFDWNMLK
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| PDB ID: 6RU7 Crystal structure of Casein Kinase I delta (CK1d) in complex with double phosphorylated p63 PAD2P peptide | ||||||
| Method | X-ray diffraction | Resolution | 2.08 Å | Mutation | No | [1] |
| PDB Sequence |
LRVGNRYRLG
12 RKIGSGSFGD22 IYLGTDIAAG32 EEVAIKLECV42 KTKHPQLHIE52 SKIYKMMQGG 62 VGIPTIRWCG72 AEGDYNVMVM82 ELLGPSLEDL92 FNFCSRKFSL102 KTVLLLADQM 112 ISRIEYIHSK122 NFIHRDVKPD132 NFLMGLGKKG142 NLVYIIDFGL152 AKKYRDARTH 162 QHIPYRENKN172 LTGTARYASI182 NTHLGIEQSR192 RDDLESLGYV202 LMYFNLGSLP 212 WQGLKAATKR222 QKYERISEKK232 MSTPIEVLCK242 GYPSEFATYL252 NFCRSLRFDD 262 KPDYSYLRQL272 FRNLFHRQGF282 SYDYVFDWNM292 LK
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | p63 uses a switch-like mechanism to set the threshold for induction of apoptosis. Nat Chem Biol. 2020 Oct;16(10):1078-1086. | ||||
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