Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T87109 Target Info
Target Name Casein kinase I delta (CSNK1D)
Synonyms Tau-protein kinase CSNK1D; HCKID; Casein kinase I isoform delta; CKId; CKI-delta
Target Type Preclinical Target
Gene Name CSNK1D
Biochemical Class Kinase
UniProt ID
KC1D_HUMAN
Ligand General Information  Top
Ligand Name adenosine diphosphate Ligand Info
Canonical SMILES C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
InChI 1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKey XTWYTFMLZFPYCI-KQYNXXCUSA-N
PubChem Compound ID 6022
Drug Binding Sites of Target  Top
PDB ID: 6RU8      Crystal structure of Casein Kinase I delta (CK1d) in complex with triple phosphorylated p63 PAD3P peptide
Method X-ray diffraction Resolution 1.92 Å Mutation No [1]
PDB Sequence
ELRVGNRYRL
11
GRKIGSGSFG
21
DIYLGTDIAA
31
GEEVAIKLEC
41
VKTKHPQLHI
51

ESKIYKMMQG
61
GVGIPTIRWC
71
GAEGDYNVMV
81
MELLGPSLED
91
LFNFCSRKFS
101

LKTVLLLADQ
111
MISRIEYIHS
121
KNFIHRDVKP
131
DNFLMGLGKK
141
GNLVYIIDFG
151

LAKKYRDART
161
HQHIPYRENK
171
NLTGTARYAS
181
INTHLGIEQS
191
RRDDLESLGY
201

VLMYFNLGSL
211
PWQGLKAATK
221
RQKYERISEK
231
KMSTPIEVLC
241
KGYPSEFATY
251

LNFCRSLRFD
261
DKPDYSYLRQ
271
LFRNLFHRQG
281
FSYDYVFDWN
291
MLK
Residue
Distance (Å)
ILE15
3.794
GLY16
3.585
SER17
3.569
GLY18
3.476
SER19
4.994
PHE20
4.421
ILE23
3.426
ALA36
3.539
LYS38
2.749
GLU52
2.453
TYR56
2.433
PRO66
4.984
Residue
Distance (Å)
MET80
4.652
MET82
3.268
GLU83
2.870
LEU84
3.875
LEU85
2.911
GLY86
4.760
ASP132
4.187
ASN133
4.777
LEU135
3.733
ILE148
3.595
ASP149
2.862
PHE150
4.513
PDB ID: 6RU7      Crystal structure of Casein Kinase I delta (CK1d) in complex with double phosphorylated p63 PAD2P peptide
Method X-ray diffraction Resolution 2.08 Å Mutation No [1]
PDB Sequence
LRVGNRYRLG
12
RKIGSGSFGD
22
IYLGTDIAAG
32
EEVAIKLECV
42
KTKHPQLHIE
52

SKIYKMMQGG
62
VGIPTIRWCG
72
AEGDYNVMVM
82
ELLGPSLEDL
92
FNFCSRKFSL
102

KTVLLLADQM
112
ISRIEYIHSK
122
NFIHRDVKPD
132
NFLMGLGKKG
142
NLVYIIDFGL
152

AKKYRDARTH
162
QHIPYRENKN
172
LTGTARYASI
182
NTHLGIEQSR
192
RDDLESLGYV
202

LMYFNLGSLP
212
WQGLKAATKR
222
QKYERISEKK
232
MSTPIEVLCK
242
GYPSEFATYL
252

NFCRSLRFDD
262
KPDYSYLRQL
272
FRNLFHRQGF
282
SYDYVFDWNM
292
LK
Residue
Distance (Å)
ILE15
3.891
GLY16
3.476
SER17
3.708
GLY18
3.322
SER19
4.710
PHE20
4.164
ILE23
3.249
ALA36
3.563
LYS38
2.603
GLU52
2.642
TYR56
2.316
PRO66
4.944
Residue
Distance (Å)
MET80
4.572
MET82
3.082
GLU83
2.870
LEU84
3.827
LEU85
2.866
GLY86
4.753
ASP132
3.992
ASN133
4.537
LEU135
3.693
ILE148
3.585
ASP149
2.860
PHE150
4.446
References  Top
REF 1 p63 uses a switch-like mechanism to set the threshold for induction of apoptosis. Nat Chem Biol. 2020 Oct;16(10):1078-1086.

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