Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86773 | Target Info | |||
| Target Name | ATP-dependent protease Lon (LONP1) | ||||
| Synonyms | Serine protease 15; Mitochondrial ATP-dependent protease Lon; Lon protease-like protein; LONP1; LONP; LONHs | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | LONP1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Bortezomib | Ligand Info | |||
| Canonical SMILES | B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O | ||||
| InChI | 1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1 | ||||
| InChIKey | GXJABQQUPOEUTA-RDJZCZTQSA-N | ||||
| PubChem Compound ID | 387447 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7KRZ Human mitochondrial LONP1 in complex with Bortezomib | ||||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
IEEKFRERLK
426 ELVVPKHVMD436 VVDEELSKLG446 LLDNHSSEFN456 VTRNYLDWLT466 SIPWGKYSNE 476 NLDLARAQAV486 LEEDHYGMED496 VKKRILEFIA506 VSQLRGSTQG516 KILCFYGPPG 526 VGKTSIARSI536 ARALNREYFR546 FSVGGMTDVA556 EIKGHRRTYV566 GAMPGKIIQC 576 LKKTKTENPL586 ILIDEVDKIG596 RGYQGDPSSA606 LLELLDPEQN616 ANFLDHYLDV 626 PVDLSKVLFI636 CTANVTDTIP646 EPLRDRMEMI656 NVSGYVAQEK666 LAIAERYLVP 676 QARALCGLDE686 SKAKLSSDVL696 TLLIKQYCRE706 SGVRNLQKQV716 EKVLRKSAYK 726 IVSGEAESVE736 VTPENLQDFV746 GKPVFTVERM756 YDVTPPGVVM766 GLAWTAMGGS 776 TLFVETSLRR786 PQDKDGSLEV802 TGQLGEVMKE812 SARIAYTFAR822 AFLMQHAPAN 832 DYLVTSHIHL842 HVPEGATPKD852 GPSAGCTIVT862 ALLSLAMGRP872 VRQNLAMTGE 882 VSLTGKILPV892 GGIKEKTIAA902 KRAGVTCIVL912 PAENKKDFYD922 LAAFITEGLE 932 VHFVEHYREI942 FDIAF
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| PDB ID: 6X27 Lon protease proteolytic domain complexed with bortezomib | ||||||
| Method | X-ray diffraction | Resolution | 2.12 Å | Mutation | No | [2] |
| PDB Sequence |
ERMYDVTPPG
763 VVMGLAWTAM773 GGSTLFVETS783 LRRPDGSLEV802 TGQLGEVMKE812 SARIAYTFAR 822 AFLMQHAPAN832 DYLVTSHIHL842 HVPEGATPKD852 GPSAGCTIVT862 ALLSLAMGRP 872 VRQNLAMTGE882 VSLTGKILPV892 GGIKEKTIAA902 KRAGVTCIVL912 PAENKKDFYD 922 LAAFITEGLE932 VHFVEHYREI942 FDIAFP
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nat Commun. 2021 May 28;12(1):3239. | ||||
| REF 2 | Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology. J Med Chem. 2021 Apr 22;64(8):4857-4869. | ||||
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