Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T81358 | Target Info | |||
| Target Name | CDC7-related kinase (CDC7) | ||||
| Synonyms | huCdc7; HsCdc7; Cell division cycle 7related protein kinase; Cell division cycle 7-related protein kinase; CDC7related kinase; CDC7L1 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CDC7 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | L-serine-O-phosphate | Ligand Info | |||
| Canonical SMILES | C(C(C(=O)O)N)OP(=O)(O)O | ||||
| InChI | 1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 | ||||
| InChIKey | BZQFBWGGLXLEPQ-REOHCLBHSA-N | ||||
| PubChem Compound ID | 68841 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6YA6 Minimal construct of Cdc7-Dbf4 bound to XL413 | ||||||
| Method | X-ray diffraction | Resolution | 1.44 Å | Mutation | No | [1] |
| PDB Sequence |
AGVKKDIEKL
47 YEAVPQLSNV57 FKIEDKIGEG67 TFSSVYLATA77 QLQVGPEEKI87 ALKHLIPTSH 97 PIRIAAELQC107 LTVAGGQDNV117 MGVKYCFRKN127 DHVVIAMPYL137 EHESFLDILN 147 SLSFQEVREY157 MLNLFKALKR167 IHQFGIVHRD177 VKPSNFLYNR187 RLKKYALVDF 197 GLAQGTHDTK207 IELLKFVQPA347 SLTCDCYATD357 KVCSICLSRR367 QQVAPRAGTP 377 GFRAPEVLTK387 CPNQTTAIDM397 WSAGVIFLSL407 LSGRYPFYKA417 SDDLTALAQI 427 MTIRGSRETI437 QAAKTFGKSI447 LCSKEVPAQD457 LRKLCERLRG467 AGAGGWNEVP 539 DEAYDLLDKL549 LDLNPASRIT559 AEEALLHPFF569 KDMS
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| PDB ID: 6YA8 Cdc7-Dbf4 bound to ADP-BeF3 | ||||||
| Method | X-ray diffraction | Resolution | 1.79 Å | Mutation | No | [1] |
| PDB Sequence |
AGVKKDIEKL
47 YEAVPQLSNV57 FKIEDKIGEG67 TFSSVYLATA77 QLQVGPEEKI87 ALKHLIPTSH 97 PIRIAAELQC107 LTVAGGQDNV117 MGVKYCFRKN127 DHVVIAMPYL137 EHESFLDILN 147 SLSFQEVREY157 MLNLFKALKR167 IHQFGIVHRD177 VKPSNFLYNR187 RLKKYALVDF 197 GLAQGTHDTK207 IELLKFVPAS348 LTCDCYATDK358 VCSICLSRRQ368 QVAPRAGTPG 378 FRAPEVLTKC388 PNQTTAIDMW398 SAGVIFLSLL408 SGRYPFYKAS418 DDLTALAQIM 428 TIRGSRETIQ438 AAKTFGKSIL448 CSKEVPAQDL458 RKLCERLRGA468 GGWNEVPDEA 542 YDLLDKLLDL552 NPASRITAEE562 ALLHPFFKDM572
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| PDB ID: 6YA7 Cdc7-Dbf4 bound to an Mcm2-S40 derived bivalent substrate | ||||||
| Method | X-ray diffraction | Resolution | 1.67 Å | Mutation | No | [1] |
| PDB Sequence |
GVKKDIEKLY
48 EAVPQLSNVF58 KIEDKIGEGT68 FSSVYLATAQ78 LQVGPEEKIA88 LKHLIPTSHP 98 IRIAAELQCL108 TVAGGQDNVM118 GVKYCFRKND128 HVVIAMPYLE138 HESFLDILNS 148 LSFQEVREYM158 LNLFKALKRI168 HQFGIVHRDV178 KPSNFLYNRR188 LKKYALVDFG 198 LAQGTHDTKI208 ELLKFVQSEA218 QQERPASLTC351 DCYATDKVCS361 ICLSRRQQVA 371 PRAGTPGFRA381 PEVLTKCPNQ391 TTAIDMWSAG401 VIFLSLLSGR411 YPFYKASDDL 421 TALAQIMTIR431 GSRETIQAAK441 TFGKSILCSK451 EVPAQDLRKL461 CERLRGAGAG 471 GWNEVPDEAY543 DLLDKLLDLN553 PASRITAEEA563 LLHPFFKDMS573 |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase. Structure. 2020 Aug 4;28(8):954-962.e4. | ||||
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