Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T80165 | Target Info | |||
| Target Name | Short transient receptor potential channel 6 (TRPC6) | ||||
| Synonyms | TRPC6; TRP6; STrpC6 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | TRPC6 | ||||
| Biochemical Class | Transient receptor potential catioin channel | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | [(2S)-2-[(E)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate | Ligand Info | |||
| Canonical SMILES | CCCCCCCC=CCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCC=CCCCCCCC | ||||
| InChI | 1S/C39H72O5/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(41)43-36-37(35-40)44-39(42)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h15-18,37,40H,3-14,19-36H2,1-2H3/b17-15?,18-16+/t37-/m0/s1 | ||||
| InChIKey | UGRFXJLWUONJDY-NVXOQYPQSA-N | ||||
| PubChem Compound ID | 162623415 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7DXF Structure of BTDM-bound human TRPC6 nanodisc at 2.9 angstrom in high calcium state | ||||||
| Method | Electron microscopy | Resolution | 2.90 Å | Mutation | No | [1] |
| PDB Sequence |
LSIEEERFLD
104 AAEYGNIPVV114 RKMLEECHSL124 NVNCVDYMGQ134 NALQLAVANE144 HLEITELLLK 154 KENLSRVGDA164 LLLAISKGYV174 RIVEAILSHP184 AFAEGKRLDD205 FYAYDEDGTR 215 FSHDVTPIIL225 AAHCQEYEIV235 HTLLRKGARI245 ERPHDYFCKC255 NDCNQKQKHD 265 SFSHSRSRIN275 AYKGLASPAY285 LSLSSEDPVM295 TALELSNELA305 VLANIEKEFK 315 NDYKKLSMQC325 KDFVVGLLDL335 CRNTEEVEAI345 LNGDVETLQS355 GDHGRPNLSR 365 LKLAIKYEVK375 KFVAHPNCQQ385 QLLSIWYENL395 SGLRQQTMAV405 KFLVVLAVAI 415 GLPFLALIYW425 FAPCSKMGKI435 MRGPFMKFVA445 HAASFTIFLG455 LLVMNAADRF 465 EGTFRMKTSC490 FSWMEMLIIS500 WVIGMIWAEC510 KEIWTQGPKE520 YLFELWNMLD 530 FGMLAIFAAS540 FIARFMAFWH550 ASKAQSIIDN575 VKYYNLARIK585 WDPSDPQIIS 595 EGLYAIAVVL605 SFSRIAYILP615 ANESFGPLQI625 SLGRTVKDIF635 KFMVIFIMVF 645 VAFMIGMFNL655 YSYYIGAKQN665 EAFTTVEESF675 KTLFWAIFGL685 SEVKSVVINY 695 NHKFIENIGY705 VLYGVYNVTM715 VIVLLNMLIA725 MINSSFQEIE735 DDADVEWKFA 745 RAKLWFSYFE755 EGRTLPVPFN765 LVPRQYQKIM859 KRLIKRYVLQ869 AQIDKESDEV 879 NEGELKEIKQ889 DISSLRYELL899 EEKSQ
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| PDB ID: 7DXG Structure of SAR7334-bound TRPC6 at 2.9 angstrom | ||||||
| Method | Electron microscopy | Resolution | 2.90 Å | Mutation | No | [1] |
| PDB Sequence |
LSIEEERFLD
104 AAEYGNIPVV114 RKMLEECHSL124 NVNCVDYMGQ134 NALQLAVANE144 HLEITELLLK 154 KENLSRVGDA164 LLLAISKGYV174 RIVEAILSHP184 AFAEGKRLDD205 FYAYDEDGTR 215 FSHDVTPIIL225 AAHCQEYEIV235 HTLLRKGARI245 ERPHDYFCKC255 NDCNQKQKHD 265 SFSHSRSRIN275 AYKGLASPAY285 LSLSSEDPVM295 TALELSNELA305 VLANIEKEFK 315 NDYKKLSMQC325 KDFVVGLLDL335 CRNTEEVEAI345 LNGDVETLQS355 GDHGRPNLSR 365 LKLAIKYEVK375 KFVAHPNCQQ385 QLLSIWYENL395 SGLRQQTMAV405 KFLVVLAVAI 415 GLPFLALIYW425 FAPCSKMGKI435 MRGPFMKFVA445 HAASFTIFLG455 LLVMNAADRF 465 EGTLFRMKTS489 CFSWMEMLII499 SWVIGMIWAE509 CKEIWTQGPK519 EYLFELWNML 529 DFGMLAIFAA539 SFIARFMAFW549 HASKAQSIID574 NVKYYNLARI584 KWDPSDPQII 594 SEGLYAIAVV604 LSFSRIAYIL614 PANESFGPLQ624 ISLGRTVKDI634 FKFMVIFIMV 644 FVAFMIGMFN654 LYSYYIGAKQ664 NEAFTTVEES674 FKTLFWAIFG684 LSEVKSVVIN 694 YNHKFIENIG704 YVLYGVYNVT714 MVIVLLNMLI724 AMINSSFQDA738 DVEWKFARAK 748 LWFSYFEEGR758 TLPVPFNLVP768 RQYQKIMKRL862 IKRYVLQAQI872 DKESDEVNEG 882 ELKEIKQDIS892 SLRYELLEEK902 SQNTEDLAEL912 IRELGEKL
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. Neuron. 2022 Mar 16;110(6):1023-1035.e5. | ||||
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