Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T79747 Target Info
Target Name Protein-serine O-palmitoleoyltransferase porcupine (PORCN)
Synonyms Protein-cysteine N-palmitoyltransferase porcupine; Protein MG61; PORCN
Target Type Clinical trial Target
Gene Name PORCN
Biochemical Class Acyltransferase
UniProt ID
PORCN_HUMAN
Ligand General Information  Top
Ligand Name Cholesterol Ligand Info
Canonical SMILES CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
InChI 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChIKey HVYWMOMLDIMFJA-DPAQBDIFSA-N
PubChem Compound ID 5997
Drug Binding Sites of Target  Top
PDB ID: 7URD      Human PORCN in complex with LGK974 and WNT3A peptide
Method Electron microscopy Resolution 2.92 Å Mutation No [1]
PDB Sequence
FSRQEFFQQL
13
LQGCLLPTAQ
23
QGLDQIWLLL
33
AICLACRLLW
43
RLGLPSYLKH
53

ASTVAGGFFS
63
LYHFFQLHMV
73
WVVLLSLLCY
83
LVLFLCRHSS
93
HRGVFLSVTI
103

LIYLLMGEMH
113
MVDTVTWHKM
123
RGAQMIVAMK
133
AVSLGFDLDR
143
GEVGTVPSPV
153

EFMGYLYFVG
163
TIVFGPWISF
173
HSYLQAVQGR
183
PLSCRWLQKV
193
ARSLALALLC
203

LVLSTCVGPY
213
LFPYFIPLNA
234
RWLRAYESAV
244
SFHFSNYFVG
254
FLSEATATLA
264

GAGFTEEKDH
274
LEWDLTVSKP
284
LNVELPRSMV
294
EVVTSWNLPM
304
SYWLNNYVFK
314

NALRLGTFSA
324
VLVTYAASAL
334
LHGFSFHLAA
344
VLLSLAFITY
354
VEHVLRKRLA
364

RILSACVLSK
374
RCPPDCSHQH
384
RLGLGVRALN
394
LLFGALAIFH
404
LAYLGSLFDV
414

YGMAYTVHKW
434
SELSWASHWV
444
TFGCWIFYRL
454
IG
Residue
Distance (Å)
ARG6
3.623
GLN7
2.568
PHE10
3.687
TYR217
4.338
PHE218
3.398
ILE219
3.691
Residue
Distance (Å)
VAL431
3.427
TRP439
2.526
HIS442
3.500
TRP443
3.586
PHE446
3.528
PDB ID: 7URA      Human PORCN in complex with Palmitoleoyl-CoA
Method Electron microscopy Resolution 3.11 Å Mutation No [1]
PDB Sequence
FSRQEFFQQL
13
LQGCLLPTAQ
23
QGLDQIWLLL
33
AICLACRLLW
43
RLGLPSYLKH
53

ASTVAGGFFS
63
LYHFFQLHMV
73
WVVLLSLLCY
83
LVLFLCRHSS
93
HRGVFLSVTI
103

LIYLLMGEMH
113
MVDTVTWHKM
123
RGAQMIVAMK
133
AVSLGFDLDR
143
GEVGTVPSPV
153

EFMGYLYFVG
163
TIVFGPWISF
173
HSYLQAVQGR
183
PLSCRWLQKV
193
ARSLALALLC
203

LVLSTCVGPY
213
LFPYFIPLNA
234
RWLRAYESAV
244
SFHFSNYFVG
254
FLSEATATLA
264

GAGFTEEKDH
274
LEWDLTVSKP
284
LNVELPRSMV
294
EVVTSWNLPM
304
SYWLNNYVFK
314

NALRLGTFSA
324
VLVTYAASAL
334
LHGFSFHLAA
344
VLLSLAFITY
354
VEHVLRKRLA
364

RILSACVLSK
374
RCPPDCSHQH
384
RLGLGVRALN
394
LLFGALAIFH
404
LAYLGSLFDV
414

YGMAYTVHKW
434
SELSWASHWV
444
TFGCWIFYRL
454
IG
Residue
Distance (Å)
ARG6
3.332
GLN7
4.230
PHE10
3.540
LEU206
3.727
VAL210
3.725
TYR217
4.344
Residue
Distance (Å)
PHE218
3.241
VAL431
3.623
TRP439
3.693
HIS442
3.992
TRP443
3.799
PHE446
3.558
PDB ID: 7URC      Human PORCN in complex with LGK974
Method Electron microscopy Resolution 3.14 Å Mutation No [1]
PDB Sequence
FSRQEFFQQL
13
LQGCLLPTAQ
23
QGLDQIWLLL
33
AICLACRLLW
43
RLGLPSYLKH
53

ASTVAGGFFS
63
LYHFFQLHMV
73
WVVLLSLLCY
83
LVLFLCRHSS
93
HRGVFLSVTI
103

LIYLLMGEMH
113
MVDTVTWHKM
123
RGAQMIVAMK
133
AVSLGFDLDR
143
GEVGTVPSPV
153

EFMGYLYFVG
163
TIVFGPWISF
173
HSYLQAVQGR
183
PLSCRWLQKV
193
ARSLALALLC
203

LVLSTCVGPY
213
LFPYFIPLNA
234
RWLRAYESAV
244
SFHFSNYFVG
254
FLSEATATLA
264

GAGFTEEKDH
274
LEWDLTVSKP
284
LNVELPRSMV
294
EVVTSWNLPM
304
SYWLNNYVFK
314

NALRLGTFSA
324
VLVTYAASAL
334
LHGFSFHLAA
344
VLLSLAFITY
354
VEHVLRKRLA
364

RILSACVLSK
374
RCPPDCSHQH
384
RLGLGVRALN
394
LLFGALAIFH
404
LAYLGSLFDV
414

YGMAYTVHKW
434
SELSWASHWV
444
TFGCWIFYRL
454
IG
Residue
Distance (Å)
ARG6
3.406
GLN7
4.180
PHE10
3.360
GLN11
3.654
LEU13
3.602
LEU14
3.956
LEU18
4.565
LEU37
3.890
LEU41
4.766
LEU104
4.352
LEU108
4.869
LEU185
3.415
SER186
3.452
CYS187
3.834
TRP189
4.261
LEU190
3.421
LEU202
3.774
VAL205
4.346
LEU206
4.298
VAL210
4.607
TYR217
4.671
PHE218
4.121
ILE219
4.351
TRP236
4.444
ARG318
4.276
LEU319
3.632
SER323
3.592
LEU326
3.646
VAL327
3.815
Residue
Distance (Å)
TYR329
4.838
ALA330
3.806
ALA331
4.834
ALA333
4.900
LEU334
4.188
PHE338
3.571
PHE340
3.713
ALA343
3.761
ALA344
4.617
LEU347
3.644
SER348
4.601
PHE351
3.753
LEU396
3.711
ALA399
3.623
LEU400
3.843
PHE403
3.593
MET427
4.670
VAL431
3.562
TRP434
4.126
SER435
4.691
LEU437
4.733
SER438
3.469
TRP439
3.505
ALA440
4.466
HIS442
3.349
TRP443
3.599
VAL444
4.177
PHE446
3.614
References  Top
REF 1 Mechanisms and inhibition of Porcupine-mediated Wnt acylation. Nature. 2022 Jul;607(7920):816-822.

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