Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T78277 | Target Info | |||
| Target Name | Asparaginase (ASRGL1) | ||||
| Synonyms | Lasparagine amidohydrolase; Isoaspartyl peptidase/Lasparaginase beta chain; Isoaspartyl peptidase/Lasparaginase; Isoaspartyl dipeptidase; Betaaspartylpeptidase; Asparaginaselike protein 1; ASRGL1 | ||||
| Target Type | Successful Target | ||||
| Gene Name | ASRGL1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | L-aspartic acid | Ligand Info | |||
| Canonical SMILES | C(C(C(=O)O)N)C(=O)O | ||||
| InChI | 1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1 | ||||
| InChIKey | CKLJMWTZIZZHCS-REOHCLBHSA-N | ||||
| PubChem Compound ID | 5960 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 4PVR Crystal structure of partially-cleaved human l-asparaginase protein in complex with l-aspartate | ||||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [1] |
| PDB Sequence |
HMNPIVVVHG
9 GGAGPISKDR19 KERVHQGMVR29 AATVGYGILR39 EGGSAVDAVE49 GAVVALEDDP 59 EFNAGCGSVL69 NTNGEVEMDA79 SIMDGKDLSA89 GAVSAVQCIA99 NPIKLARLVM 109 EKTPHCFLTD119 QGAAQFAAAM129 GVPEIPGEKL139 VTERNKKRLE149 KEKHNLGTVG 170 AVALDCKGNV180 AYATSTGGIV190 NKMVGRVGDS200 PCLGAGGYAD210 NDIGAVSTTG 220 HGESILKVNL230 ARLTLFHIEQ240 GKTVEEAADL250 SLGYMKSRVK260 GLGGLIVVSK 270 TGDWVAKWTS280 TSMPWAAAKD290 GKLHFGIDPD300 DTTITDLP
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| PDB ID: 4PVS Crystal structure of fully-cleaved human l-asparaginase protein in complex with l-aspartate | ||||||
| Method | X-ray diffraction | Resolution | 1.84 Å | Mutation | No | [1] |
| PDB Sequence |
HMNPIVVVHG
9 GGAGPISKDR19 KERVHQGMVR29 AATVGYGILR39 EGGSAVDAVE49 GAVVALEDDP 59 EFNAGCGSVL69 NTNGEVEMDA79 SIMDGKDLSA89 GAVSAVQCIA99 NPIKLARLVM 109 EKTPHCFLTD119 QGAAQFAAAM129 GVPEIPGEKL139 VTERNKKRLE149 KEKHTVGAVA 173 LDCKGNVAYA183 TSTGGIVNKM193 VGRVGDSPCL203 GAGGYADNDI213 GAVSTTGHGE 223 SILKVNLARL233 TLFHIEQGKT243 VEEAADLSLG253 YMKSRVKGLG263 GLIVVSKTGD 273 WVAKWTSTSM283 PWAAAKDGKL293 HFGIDPDDTT303 ITDLP
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis. Biochemistry. 2012 Aug 28;51(34):6816-26. | ||||
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