Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T73863 | Target Info | |||
| Target Name | Lysine-specific demethylase 4C (KDM4C) | ||||
| Synonyms | KIAA0780; Jumonji domain-containing protein 2C; JmjC domain-containing histone demethylation protein 3C; JMJD2C; JHDM3C; Gene amplified in squamous cell carcinoma 1 protein; GASC1; GASC-1 protein | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | KDM4C | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | 2-(carboxymethylamino)-2-oxoacetic acid | Ligand Info | |||
| Canonical SMILES | C(C(=O)O)NC(=O)C(=O)O | ||||
| InChI | 1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10) | ||||
| InChIKey | BIMZLRFONYSTPT-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 3080614 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 2XML Crystal structure of human JMJD2C catalytic domain | ||||||
| Method | X-ray diffraction | Resolution | 2.55 Å | Mutation | No | [1] |
| PDB Sequence |
LNPSCKIMTF
19 RPSMEEFREF29 NKYLAYMESK39 GAHRAGLAKV49 IPPKEWKPRQ59 CYDDIDNLLI 69 PAPIQQMVTG79 QSGLFTQYNI89 QKKAMTVKEF99 RQLANSGKYC109 TPRYLDYEDL 119 ERKYWKNLTF129 VAPIYGADIN139 GSIYDEGVDE149 WNIARLNTVL159 DVVEEECGIS 169 IEGVNTPYLY179 FGMWKTTFAW189 HTEDMDLYSI199 NYLHFGEPKS209 WYAIPPEHGK 219 RLERLAQGFF229 PSSSQGCDAF239 LRHKMTLISP249 SVLKKYGIPF259 DKITQEAGEF 269 MITFPYGYHA279 GFNHGFNCAE289 STNFATVRWI299 DYGKVAKLCT309 CRKDMVKISM 319 DIFVRKFQPD329 RYQLWKQGKD339 IYTIDHTK
|
|||||
|
|
||||||
| PDB ID: 4XDO Crystal structure of human KDM4C catalytic domain with OGA | ||||||
| Method | X-ray diffraction | Resolution | 1.97 Å | Mutation | No | [2] |
| PDB Sequence |
LNPSCKIMTF
19 RPSMEEFREF29 NKYLAYMESK39 GAHRAGLAKV49 IPPKEWKPRQ59 CYDDIDNLLI 69 PAPIQQMVTG79 QSGLFTQYNI89 QKKAMTVKEF99 RQLANSGKYC109 TPRYLDYEDL 119 ERKYWKNLTF129 VAPIYGADIN139 GSIYDEGVDE149 WNIARLNTVL159 DVVEEECGIS 169 IEGVNTPYLY179 FGMWKTTFAW189 HTEDMDLYSI199 NYLHFGEPKS209 WYAIPPEHGK 219 RLERLAQGFF229 PSSSQGCDAF239 LRHKMTLISP249 SVLKKYGIPF259 DKITQEAGEF 269 MITFPYGYHA279 GFNHGFNCAE289 STNFATVRWI299 DYGKVAKLCT309 CRKDMVKISM 319 DIFVRKFQPD329 RYQLWKQGKD339 IYTIDHTK
|
|||||
|
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family. J Biol Chem. 2011 Dec 2;286(48):41616-41625. | ||||
| REF 2 | A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening. J Biomol Screen. 2015 Jul;20(6):810-20. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.