Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T73694 | Target Info | |||
| Target Name | Tyrosine-protein kinase BRK (PTK6) | ||||
| Synonyms | Protein-tyrosine kinase 6; Breast tumor kinase; BRK | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PTK6 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | N-carboxymethionine | Ligand Info | |||
| Canonical SMILES | CSCCC(C(=O)O)NC(=O)O | ||||
| InChI | 1S/C6H11NO4S/c1-12-3-2-4(5(8)9)7-6(10)11/h4,7H,2-3H2,1H3,(H,8,9)(H,10,11)/t4-/m0/s1 | ||||
| InChIKey | LWQBAQJPCYBWJQ-BYPYZUCNSA-N | ||||
| PubChem Compound ID | 17753927 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 5H2U Crystal structure of PTK6 Kinase Domain complexed with Dasatinib | ||||||
| Method | X-ray diffraction | Resolution | 2.24 Å | Mutation | Yes | [1] |
| PDB Sequence |
ERPREEFTLC
194 RKLGSGYFGE204 VFEGLWKDRV214 QVAIKVISRD224 NLLHQQMLQS234 EIQAMKKLRH 244 KHILALYAVV254 SVGDPVYIIT264 ELMAKGSLLE274 LLRSDEKVLP285 VSELLDIAWQ 295 VAEGMCYLES305 QNYIHRDLAA315 RNILVGENTL325 CKVGDFGLAR335 LIKEDVYLSH 345 DHNIPYKWTA355 PEALSRGHYS365 TKSDVWSFGI375 LLHEMFSRGQ385 VPYPGMSNHE 395 AFLRVDAGYR405 MPCPLECPPS415 VHKLMLTCWC425 RDPEQRPTFK435 ALRERLSSFT 445 SHHHH
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| PDB ID: 5DA3 Crystal structure of PTK6 Kinase domain with inhibitor | ||||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | Yes | [1] |
| PDB Sequence |
ERPREEFTLC
194 RKLGSGYFGE204 VFEGLWKDRV214 QVAIKVISRD224 NLLHQMLQSE235 IQAMKKLRHK 245 HILALYAVVS255 VGDPVYIITE265 LMAKGSLLEL275 LRDSDEKVLP285 VSELLDIAWQ 295 VAEGMCYLES305 QNYIHRDLAA315 RNILVGENTL325 CKVGDFGLAR335 LIKEDVYLSH 345 DHNIPYKWTA355 PEALSRGHYS365 TKSDVWSFGI375 LLHEMFSRGQ385 VPYPGMSNHE 395 AFLRVDAGYR405 MPCPLECPPS415 VHKLMLTCWC425 RDPEQRPTFK435 ALRERLSSFT 445 SHH
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Co-crystal structures of PTK6: With Dasatinib at 2.24??, with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70?? resolution. Biochem Biophys Res Commun. 2017 Jan 22;482(4):1289-1295. | ||||
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