Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T66686 | Target Info | |||
| Target Name | Bacterial Penicillin-binding protein 1B (Bact mrcB) | ||||
| Synonyms | mrcB; PBP1b; PBP-1b; PBP 1b; Murein polymerase | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | Bact mrcB | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | (2R)-3-[[(2R,3R,4R,5S,6S)-3-[(2S,3R,4R,5S,6R)-3-acetamido-5-[(2S,3R,4R,5S,6R)-3-acetamido-4-hydroxy-6-methyl-5-[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-[(2-hydroxy-5-oxocyclopenta-1,3-dien-1-yl)carbamoyl]oxan-2-yl]oxyoxan-2-yl]oxy-4-hydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-6-carbamoyl-4-carbamoyloxy-5-hydroxy-5-methyloxan-2-yl]oxy-hydroxyphosphoryl]oxy-2-(3,8,8,14,18-pentamethyl-11-methylidenenonadeca-2,6,13,17-tetraenoxy)propanoic acid | Ligand Info | |||
| Canonical SMILES | CC1C(C(C(C(O1)OC2C(OC(C(C2O)NC(=O)C)OC3C(C(C(OC3OP(=O)(O)OCC(C(=O)O)OCC=C(C)CCC=CC(C)(C)CCC(=C)CC=C(C)CCC=C(C)C)C(=O)N)(C)O)OC(=O)N)COC4C(C(C(C(O4)CO)O)O)O)NC(=O)C)O)OC5C(C(C(C(O5)C(=O)NC6=C(C=CC6=O)O)O)O)O | ||||
| InChI | 1S/C69H106N5O34P/c1-30(2)15-14-17-31(3)18-19-33(5)22-25-68(9,10)24-13-12-16-32(4)23-26-96-41(61(90)91)29-98-109(94,95)108-66-56(57(107-67(71)92)69(11,93)58(106-66)59(70)88)105-63-44(73-36(8)77)47(82)54(40(101-63)28-97-64-51(86)48(83)45(80)39(27-75)100-64)103-62-43(72-35(7)76)46(81)53(34(6)99-62)102-65-52(87)49(84)50(85)55(104-65)60(89)74-42-37(78)20-21-38(42)79/h13,15,18,20-21,23-24,34,39-41,43-58,62-66,75,80-87,93H,5,12,14,16-17,19,22,25-29H2,1-4,6-11H3,(H2,70,88)(H2,71,92)(H,72,76)(H,73,77)(H,90,91)(H,94,95)(H2,74,78,79,89)/t34-,39-,40-,41-,43-,44-,45-,46-,47-,48+,49+,50-,51-,52-,53-,54-,55+,56-,57-,58-,62+,63+,64-,65-,66-,69+/m1/s1 | ||||
| InChIKey | NXPRJQIAIORCGO-ZLPAOQQDSA-N | ||||
| PubChem Compound ID | 137349720 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 3VMA Crystal Structure of the Full-Length Transglycosylase PBP1b from Escherichia coli | ||||||
| Method | X-ray diffraction | Resolution | 2.16 Å | Mutation | No | [1] |
| PDB Sequence |
LAIVFAVLIA
81 IYGVYLDQKI91 RSRIDGKVWQ101 LPAAVYGRMV111 NLEPDMTISK121 NEMVKLLEAT 131 QYRQVSKMTR141 PGEFTVQANS151 IEMIRRPFDF161 PDSKEGQVRA171 RLTFDGDHLA 181 TIVNMENNRQ191 FGFFRLDPRL201 ITMISSPNGE211 QRLFVPRSGF221 PDLLVDTLLA 231 TEDRHFYEHY246 SIGRATLTQQ271 LVKNLFLSSE281 RSYWRKANEA291 YMALIMDARY 301 SKDRILELYM311 NEVYLGQSGD321 NEIRGFPLAS331 LYYFGRPVEE341 LSLDQQALLV 351 GMVKGASIYN361 PWRNPKLALE371 RRNLVLRLLQ381 QQQIIDQELY391 DMLSARPLVQ 402 PRGGVISPQP412 AFMQLVRQEL422 QAKLGDKVKD432 LSGVKIFTTF442 DSVAQDAAEK 452 AAVEGIPALK462 KQRKLSDLET472 AIVVVDRFSG482 EVRAMVGGSE492 PQFAGYNRAM 502 QARRSIGSLA512 KPATYLTALS522 QPKIYRLNTW532 IADAPIALRQ542 PNGQVWSPQN 552 DDRRYSESGR562 VMLVDALTRS572 MNVPTVNLGM582 ALGLPAVTET592 WIKLGVPKDQ 602 LHPVPAMLLG612 ALNLTPIEVA622 QAFQTIASGG632 NRAPLSALRS642 VIAEDGKVLY 652 QSFPQAERAV662 PAQAAYLTLW672 TMQQVVQRGT682 GRQLGAKYPN692 LHLAGKTGTT 702 NNNVDTWFAG712 IDGSTVTITW722 VGRDNNQPTK732 LYGASGAMSI742 YQRYLANQTP 752 TPLNLVPPED762 IADMGVDYDG772 NFVCSGGMRI782 LPVWTSDPQS792 LCQQSEMQ |
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| PDB ID: 3FWL Crystal Structure of the Full-Length Transglycosylase PBP1b from Escherichia coli | ||||||
| Method | X-ray diffraction | Resolution | 3.09 Å | Mutation | No | [1] |
| PDB Sequence |
LWLLLKLAIV
75 FAVLIAIYGV85 YLDQKIRSRI95 DGKVWQLPAA105 VYGRVNLEPD116 TISKNEVKLL 128 EATQYRQVSK138 TRPGEFTVQA149 NSIEIRRPFD160 FPDSKEGQVR170 ARLTFDGDHL 180 ATIVNENNRQ191 FGFFRLDPRL201 ITISSPNGEQ212 RLFVPRSGFP222 DLLVDTLLAT 232 EDRHFYEHDG242 ISLYSILTQQ271 LVKNLFLSSE281 RSYWRKANEA291 YALIDARYSK 303 DRILELYNEV314 YLGQSGDNEI324 RGFPLASLYY334 FGRPVEELSL344 DQQALLVGVK 355 GASIYNPWRN365 PKLALERRNL375 VLRLLQQQQI385 IDQELYDLSA396 RPVISPQPAF 414 QLVRQELQAK425 LGDKVKDLSG435 VKIFTTFDSV445 AQDAAEKAAV455 EGIPALKKQR 465 KLSDLETAIV475 VVDRFSGEVR485 AVGGSEPQFA496 GYNRAQARRS507 IGSLAKPATY 517 LTALSQPKIY527 RLNTWIADAP537 IALRQPNGQV547 WSPQNDDRRY557 SESGRVLVDA 568 LTRSNVPTVN579 LGALGLPAVT590 ETWIKLGVPK600 DQLHPVPALL611 GALNLTPIEV 621 AQAFQTIASG631 GNRAPLSALR641 SVIAEDGKVL651 YQSFPQAERA661 VPAQAAYLTL 671 WTQQVVQRGT682 GRQLGAKYPN692 LHLAGKTGTT702 NNNVDTWFAG712 IDGSTVTITW 722 VGRDNNQPTK732 LYGASGASIY743 QRYLANQTPT753 PLNLVPPEDI763 ADGVDYDGNF 774 VCSGGRILPV785 WTSDPQSLCQ795 QSE
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GLU233
3.220
TYR246
3.891
LEU268
4.661
GLN271
2.574
LYS274
2.579
ASN275
4.420
GLU281
4.405
SER283
4.533
ARG286
3.245
LYS287
3.940
GLU290
3.829
|
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| PDB ID: 5HLD E. coli PBP1b in complex with acyl-CENTA and moenomycin | ||||||
| Method | X-ray diffraction | Resolution | 2.31 Å | Mutation | No | [2] |
| PDB Sequence |
AIVFAVLIAI
82 YGVYLDQKIR92 SRIDGKVWQL102 PAAVYGRMVN112 LEPDMTISKN122 EMVKLLEATQ 132 YRQVSKMTRP142 GEFTVQANSI152 EMIRRPFDFP162 DSKEGQVRAR172 LTFDGDHLAT 182 IVNMENNRQF192 GFFRLDPRLI202 TMISSPNGEQ212 RLFVPRSGFP222 DLLVDTLLAT 232 ETQQLVKNLF277 LSKANEAYMA294 LIMDARYSKD304 RILELYMNEV314 YLGQSGDNEI 324 RGFPLASLYY334 FGRPVEELSL344 DQQALLVGMV354 LALERRNLVL377 RLLYDMLSAR 397 PQPAFMQLVR419 QELQAKLGDK429 VKDLSGVKIF439 TTFDSVAQDA449 AEKAAVEGIP 459 ALKKQRKLSD469 LETAIVVVDR479 FSGEVRAMVG489 GSEPQFAGYN499 RAMQARRSIG 509 SLAKPATYLT519 ALSQPKIYRL529 NTWIADAPIA539 LRQPNGQVWS549 PQNDDRRYSE 559 SGRVMLVDAL569 TRSMNVPTVN579 LGMALGLPAV589 TETWIKLGVP599 KDQLHPVPAM 609 LLGALNLTPI619 EVAQAFQTIA629 SGGNRAPLSA639 LRSVIAEDGK649 VLYQSFPQAE 659 RAVPAQAAYL669 TLWTMQQVVQ679 RGTGRQLGAK689 YPNLHLAGKT699 GTTNNNVDTW 709 FAGIDGSTVT719 ITWVGRDNNQ729 PTKLYGASGA739 MSIYQRYLAN749 QTPTPLNLVP 759 PEDIADMGVD769 YDGNFVCSGG779 MRILPVWTSD789 PQSLCQQSE
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| PDB ID: 5HLA E. coli PBP1b in complex with acyl-cephalexin and moenomycin | ||||||
| Method | X-ray diffraction | Resolution | 2.36 Å | Mutation | No | [2] |
| PDB Sequence |
WLLLKLAIVF
76 AVLIAIYGVY86 LDQKIRSRID96 GKVWQLPAAV106 YGRMVNLEPD116 MTISKNEMVK 126 LLEATQYRQV136 SKMTRPGEFT146 VQANSIEMIR156 RPFDFPDSKE166 GQVRARLTFD 176 GDHLATIVNM186 ENNRQFGFFR196 LDPRLITMIS206 SPNGEQRLFV216 PRSGFPDLLV 226 DTLLATEDRH236 FYETLTQQLV273 KNLFLSKANE290 AYMALIMDAR300 YSKDRILELY 310 MNEVYLGQSG320 DNEIRGFPLA330 SLYYFGRPVE340 ELSLDQQALL350 VGMVKGASIY 360 NPWRNPKLAL370 ERRNLVLRLL380 QQQQIIDQEL390 YDMLSARPLQ402 PRGGVISPQP 412 AFMQLVRQEL422 QAKLGDKVKD432 LSGVKIFTTF442 DSVAQDAAEK452 AAVEGIPALK 462 KQRKLSDLET472 AIVVVDRFSG482 EVRAMVGGSE492 PQFAGYNRAM502 QARRSIGSLA 512 KPATYLTALS522 QPKIYRLNTW532 IADAPIALRQ542 PNGQVWSPQN552 DDRRYSESGR 562 VMLVDALTRS572 MNVPTVNLGM582 ALGLPAVTET592 WIKLGVPKDQ602 LHPVPAMLLG 612 ALNLTPIEVA622 QAFQTIASGG632 NRAPLSALRS642 VIAEDGKVLY652 QSFPQAERAV 662 PAQAAYLTLW672 TMQQVVQRGT682 GRQLGAKYPN692 LHLAGKTGTT702 NNNVDTWFAG 712 IDGSTVTITW722 VGRDNNQPTK732 LYGASGAMSI742 YQRYLANQTP752 TPLNLVPPED 762 IADMGVDYDG772 NFVCSGGMRI782 LPVWTSDPQS792 LCQQSEM
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .M0E or .M0E2 or .M0E3 or :3M0E;style chemicals stick;color identity;select .A:233 or .A:271 or .A:274 or .A:275 or .A:310 or .A:314 or .A:315 or .A:318 or .A:323 or .A:325 or .A:354 or .A:355 or .A:356 or .A:357 or .A:358 or .A:359; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| PDB ID: 6YN0 Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [3] |
| PDB Sequence |
IVFAVLIAIY
83 GVYLDQKIRS93 RIDGKVWQLP103 AAVYGRMVNL113 EPDMTISKNE123 MVKLLEATQY 133 RQVSKMTRPG143 EFTVQANSIE153 MIRRPFDFPD163 SKEGQVRARL173 TFDGDHLATI 183 VNMENNRQFG193 FFRLDPRLIT203 MISSPNGEQR213 LFVPRSGFPD223 LLVDTLLATE 233 DRHTQQLVKN275 LFLSSYWRKA288 NEAYMALIMD298 ARYSKDRILE308 LYMNEVYLGQ 318 SGDNEIRGFP328 LASLYYFGRP338 VEELSLDQQA348 LLVGMVKGAS358 IYNPWRNPKL 368 ALERRNLVLR378 LLQQQQIIDQ388 ELYDMLSARP398 LQPRGGVISP410 QPAFMQLVRQ 420 ELQAKLGDKV430 KDLSGVKIFT440 TFDSVAQDAA450 EKAAVEGIPA460 LKKQRKLSDL 470 ETAIVVVDRF480 SGEVRAMVGG490 SEPQFAGYNR500 AMQARRSIGS510 LAKPATYLTA 520 LSQPKIYRLN530 TWIADAPIAL540 RQPNGQVWSP550 QNDDRRYSES560 GRVMLVDALT 570 RSMNVPTVNL580 GMALGLPAVT590 ETWIKLGVPK600 DQLHPVPAML610 LGALNLTPIE 620 VAQAFQTIAS630 GGNRAPLSAL640 RSVIAEDGKV650 LYQSFPQAER660 AVPAQAAYLT 670 LWTMQQVVQR680 GTGRQLGAKY690 PNLHLAGKTG700 TTNNNVDTWF710 AGIDGSTVTI 720 TWVGRDNNQP730 TKLYGASGAM740 SIYQRYLANQ750 TPTPLNLVPP760 EDIADMGVDY 770 DGNFVCSGGM780 RILPVWTSDP790 QSLCQQSEM
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .M0E or .M0E2 or .M0E3 or :3M0E;style chemicals stick;color identity;select .A:233 or .A:270 or .A:271 or .A:274 or .A:275 or .A:287 or .A:290 or .A:310 or .A:314 or .A:315 or .A:318 or .A:320 or .A:321 or .A:323 or .A:325 or .A:354 or .A:355 or .A:356 or .A:357 or .A:358 or .A:359 or .A:360 or .A:364; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLU233
2.391
GLN270
4.747
GLN271
2.372
LYS274
1.878
ASN275
2.487
LYS287
3.197
GLU290
3.607
TYR310
3.631
VAL314
2.570
TYR315
2.453
GLN318
2.661
GLY320
4.827
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| PDB ID: 5HLB E. coli PBP1b in complex with acyl-aztreonam and moenomycin | ||||||
| Method | X-ray diffraction | Resolution | 2.42 Å | Mutation | No | [2] |
| PDB Sequence |
WLLLKLAIVF
76 AVLIAIYGVY86 LDQKIRSRID96 GKVWQLPAAV106 YGRMVNLEPD116 MTISKNEMVK 126 LLEATQYRQV136 SKMTRPGEFT146 VQANSIEMIR156 RPFDFPDSKE166 GQVRARLTFD 176 GDHLATIVNM186 ENNRQFGFFR196 LDPRLITMIS206 SPNGEQRLFV216 PRSGFPDLLV 226 DTLLATEDRH236 FYEHDGISLY246 SIGRAVLANL256 TAGRTVQGAS266 TLTQQLVKNL 276 FLSSERSYWR286 KANEAYMALI296 MDARYSKDRI306 LELYMNEVYL316 GQSGDNEIRG 326 FPLASLYYFG336 RPVEELSLDQ346 QALLVGMVKG356 ASIYNPWRNP366 KLALERRNLV 376 LRLLQQQQII386 DQELYDMLSA396 RPLGVQPRGG406 VISPQPAFMQ416 LVRQELQAKL 426 GDKVKDLSGV436 KIFTTFDSVA446 QDAAEKAAVE456 GIPALKKQRK466 LSDLETAIVV 476 VDRFSGEVRA486 MVGGSEPQFA496 GYNRAMQARR506 SIGSLAKPAT516 YLTALSQPKI 526 YRLNTWIADA536 PIALRQPNGQ546 VWSPQNDDRR556 YSESGRVMLV566 DALTRSMNVP 576 TVNLGMALGL586 PAVTETWIKL596 GVPKDQLHPV606 PAMLLGALNL616 TPIEVAQAFQ 626 TIASGGNRAP636 LSALRSVIAE646 DGKVLYQSFP656 QAERAVPAQA666 AYLTLWTMQQ 676 VVQRGTGRQL686 GAKYPNLHLA696 GKTGTTNNNV706 DTWFAGIDGS716 TVTITWVGRD 726 NNQPTKLYGA736 SGAMSIYQRY746 LANQTPTPLN756 LVPPEDIADM766 GVDYDGNFVC 776 SGGMRILPVW786 TSDPQSLCQQ796 SEM
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .M0E or .M0E2 or .M0E3 or :3M0E;style chemicals stick;color identity;select .A:233 or .A:262 or .A:263 or .A:264 or .A:265 or .A:266 or .A:271 or .A:274 or .A:275 or .A:280 or .A:281 or .A:286 or .A:287 or .A:290 or .A:310 or .A:314 or .A:315 or .A:318 or .A:323 or .A:325 or .A:354 or .A:355 or .A:356 or .A:357 or .A:358 or .A:359; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLU233
3.370
VAL262
3.096
GLN263
4.369
GLY264
3.420
ALA265
4.150
SER266
3.589
GLN271
2.500
LYS274
2.693
ASN275
2.805
SER280
4.103
GLU281
3.801
ARG286
3.526
LYS287
3.903
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| PDB ID: 5HL9 E. coli PBP1b in complex with acyl-ampicillin and moenomycin | ||||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | No | [2] |
| PDB Sequence |
LLLKLAIVFA
77 VLIAIYGVYL87 DQKIRSRIDG97 KVWQLPAAVY107 GRMVNLEPDM117 TISKNEMVKL 127 LEATQYRQVS137 KMTRPGEFTV147 QANSIEMIRR157 PFDFPDSKEG167 QVRARLTFDG 177 DHLATIVNME187 NNRQFGFFRL197 DPRLITMISN209 GEQRLFVPRS219 GFPDLLVDTL 229 LATEDRHFYT267 LTQQLVKNLF277 LSSERSYWRK287 ANEAYMALIM297 DARYSKDRIL 307 ELYMNEVYLG317 QSGDNEIRGF327 PLASLYYFGR337 PVEELSLDQQ347 ALLVGMVKGA 357 SIYNPWRNPK367 LALERRNLVL377 RLLQQQQIID387 QELYDMLSAR397 PLGVQPRGIS 409 PQPAFMQLVR419 QELQAKLVKD432 LSGVKIFTTF442 DSVAQDAAEK452 AAVEGIPALK 462 KQRKLSDLET472 AIVVVDRFSG482 EVRAMVGGSE492 PQFAGYNRAM502 QARRSIGSLA 512 KPATYLTALS522 QPKIYRLNTW532 IADAPIALRQ542 PNGQVWSPQN552 DDRRYSESGR 562 VMLVDALTRS572 MNVPTVNLGM582 ALGLPAVTET592 WIKLGVPKDQ602 LHPVPAMLLG 612 ALNLTPIEVA622 QAFQTIASGG632 NRAPLSALRS642 VIAEDGKVLY652 QSFPQAERAV 662 PAQAAYLTLW672 TMQQVVQRGT682 GRQLGAKYPN692 LHLAGKTGTT702 NNNVDTWFAG 712 IDGSTVTITW722 VGRDNNQPTK732 LYGASGAMSI742 YQRYLANQTP752 TPLNLVPPED 762 IADMGVDYDG772 NFVCSGGMRI782 LPVWTSDPQS792 LCQQS
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .M0E or .M0E2 or .M0E3 or :3M0E;style chemicals stick;color identity;select .A:233 or .A:271 or .A:274 or .A:275 or .A:280 or .A:281 or .A:282 or .A:286 or .A:287 or .A:290 or .A:310 or .A:314 or .A:315 or .A:318 or .A:323 or .A:325 or .A:354 or .A:355 or .A:356 or .A:357 or .A:358 or .A:359; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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GLU233
3.342
GLN271
2.550
LYS274
3.104
ASN275
2.906
SER280
4.543
GLU281
4.335
ARG282
4.664
ARG286
2.706
LYS287
4.858
GLU290
3.882
TYR310
3.869
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| PDB ID: 5FGZ E. coli PBP1b in complex with FPI-1465 | ||||||
| Method | X-ray diffraction | Resolution | 2.85 Å | Mutation | No | [4] |
| PDB Sequence |
LAIVFAVLIA
81 IYGVYLDQKI91 RSRIDGKVWQ101 LPAAVYGRMV111 NLEPDMTISK121 NEMVKLLEAT 131 QYRQVSKMTR141 PGEFTVQANS151 IEMIRRPFDF161 PDSKEGQVRA171 RLTFDGDHLA 181 TIVNMENNRQ191 FGFFRLDPRL201 ITMISSPNGE211 QRLFVPRSGF221 PDLLVDTLLA 231 TEDTLTQQLV273 KNLFLSSERS283 YWRKANEAYM293 ALIMDARYSK303 DRILELYMNE 313 VYLGQSGDNE323 IRGFPLASLY333 YFGRPVEELS343 LDQQALLVGM353 VKGASIYNPW 363 RNPKLALERR373 NLVLRLLQQQ383 QIIDQELYDM393 LSARPLGVQP403 RGGVISPQPA 413 FMQLVRQELQ423 AKLGDKVKDL433 SGVKIFTTFD443 SVAQDAAEKA453 AVEGIPALKK 463 QRKLSDLETA473 IVVVDRFSGE483 VRAMVGGSEP493 QFAGYNRAMQ503 ARRSIGSLAK 513 PATYLTALSQ523 PKIYRLNTWI533 ADAPIALRQP543 NGQVWSPQND553 DRRYSESGRV 563 MLVDALTRSM573 NVPTVNLGMA583 LGLPAVTETW593 IKLGVPKDQL603 HPVPAMLLGA 613 LNLTPIEVAQ623 AFQTIASGGN633 RAPLSALRSV643 IAEDGKVLYQ653 SFPQAERAVP 663 AQAAYLTLWT673 MQQVVQRGTG683 RQLGAKYPNL693 HLAGKTGTTN703 NNVDTWFAGI 713 DGSTVTITWV723 GRDNNQPTKL733 YGASGAMSIY743 QRYLANQTPT753 PLNLVPPEDI 763 ADMGVDYDGN773 FVCSGGMRIL783 PVWTSDPQSL793 CQQSEMQ
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .M0E or .M0E2 or .M0E3 or :3M0E;style chemicals stick;color identity;select .A:233 or .A:271 or .A:274 or .A:275 or .A:280 or .A:281 or .A:287 or .A:290 or .A:314 or .A:315 or .A:318 or .A:320 or .A:323 or .A:325 or .A:354 or .A:355 or .A:356 or .A:357 or .A:358 or .A:359; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLU233
2.906
GLN271
2.681
LYS274
2.928
ASN275
2.638
SER280
4.306
GLU281
2.710
LYS287
4.294
GLU290
4.285
VAL314
4.795
TYR315
3.402
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8824-9. | ||||
| REF 2 | Structural Insights into Inhibition of Escherichia coli Penicillin-binding Protein 1B. J Biol Chem. 2017 Jan 20;292(3):979-993. | ||||
| REF 3 | The bacterial cell division protein fragment (E)FtsN binds to and activates the major peptidoglycan synthase PBP1b. J Biol Chem. 2020 Dec 25;295(52):18256-18265. | ||||
| REF 4 | Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-Beta-Lactamases and Penicillin-Binding Proteins. ACS Chem Biol. 2016 Apr 15;11(4):864-8. | ||||
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