Target Binding Site Detail

Content Navigation (  All   None )                                      
Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T59875 Target Info
Target Name Estrogen-related receptor-gamma (ESRRG)
Synonyms Nuclear receptor subfamily 3 group B member 3; NR3B3; KIAA0832; Estrogen-related receptor gamma; Estrogen receptor-related protein 3; ERRG2; ERR3; ERR gamma-2
Target Type Literature-reported Target
Gene Name ESRRG
Biochemical Class Nuclear hormone receptor
UniProt ID
ERR3_HUMAN
Ligand General Information  Top
Ligand Name L-serine-O-phosphate Ligand Info
Canonical SMILES C(C(C(=O)O)N)OP(=O)(O)O
InChI 1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
InChIKey BZQFBWGGLXLEPQ-REOHCLBHSA-N
PubChem Compound ID 68841
Drug Binding Sites of Target  Top
PDB ID: 6Y3W      Ternary complex of 14-3-3 sigma (C38N), Estrogen Related Receptor gamma (DBD) phosphopeptide, and disulfide PPI stabilizer 1
Method X-ray diffraction Resolution 1.34 Å Mutation Yes [1]
PDB Sequence
RRRKCQA
Residue
Distance (Å)
ARG176
3.944
ARG177
1.932
LYS178
1.329
Residue
Distance (Å)
CYS180
1.327
GLN181
1.980
PDB ID: 6XXC      Ternary complex of 14-3-3 sigma (C38N), Estrogen Related Receptor gamma (DBD) phosphopeptide, and disulfide PPI stabilizer 4
Method X-ray diffraction Resolution 1.30 Å Mutation Yes [1]
PDB Sequence
RRRKCQ
Residue
Distance (Å)
ARG176
3.848
ARG177
1.877
LYS178
1.326
Residue
Distance (Å)
CYS180
1.323
GLN181
2.903
PDB ID: 6XY5      Ternary complex of 14-3-3 sigma (C38N), Estrogen Related Receptor gamma (DBD) phosphopeptide, and disulfide PPI stabilizer 5
Method X-ray diffraction Resolution 1.30 Å Mutation Yes [1]
PDB Sequence
RRRKCQ
Residue
Distance (Å)
ARG176
3.837
ARG177
1.894
LYS178
1.326
Residue
Distance (Å)
CYS180
1.319
GLN181
2.215
PDB ID: 6Y18      Ternary complex of 14-3-3 sigma (C38N), Estrogen Related Receptor gamma (DBD) phosphopeptide, and disulfide PPI stabilizer 3
Method X-ray diffraction Resolution 1.30 Å Mutation Yes [1]
PDB Sequence
RRRKCQ
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .B:176 or .B:177 or .B:178 or .B:180 or .B:181; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ARG176
3.935
ARG177
1.861
LYS178
1.325
Residue
Distance (Å)
CYS180
1.322
GLN181
2.320
References  Top
REF 1 Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers. ACS Chem Biol. 2020 Dec 18;15(12):3143-3148.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.