Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T59493 | Target Info | |||
| Target Name | Alanine/serine/cysteine transporter 2 (SLC1A5) | ||||
| Synonyms | Solute carrier family 1 member 5; Sodium-dependent neutral amino acid transporter type 2; RDRC; RDR; RD114/simian type D retrovirus receptor; Neutral amino acid transporter B(0); M7V1; Baboon M7 virus receptor; ATB(0); ASCT2 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SLC1A5 | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | L-glutamine | Ligand Info | |||
| Canonical SMILES | C(CC(=O)N)C(C(=O)O)N | ||||
| InChI | 1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 | ||||
| InChIKey | ZDXPYRJPNDTMRX-VKHMYHEASA-N | ||||
| PubChem Compound ID | 5961 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6MPB Cryo-EM structure of the human neutral amino acid transporter ASCT2 | ||||||
| Method | Electron microscopy | Resolution | 3.84 Å | Mutation | No | [1] |
| PDB Sequence |
DQVRRCLRAN
52 LLVLLTVVAV62 VAGVALGLGV72 SGAGGALALG82 PERLSAFVFP92 GELLLRLLRM 102 IILPLVVCSL112 IGGAASLDPG122 ALGRLGAWAL132 LFFLVTTLLA142 SALGVGLALA 152 LQPGAASAAI162 NASVGAAGSA172 ENAPSKEVLD182 SFLDLARNIF192 PSNLVSAAFR 202 SYSTTYEERN212 ITGTRVKVPV222 GQEVEGMNIL232 GLVVFAIVFG242 VALRKLGPEG 252 ELLIRFFNSF262 NEATMVLVSW272 IMWYAPVGIM282 FLVAGKIVEM292 EDVGLLFARL 302 GKYILCCLLG312 HAIHGLLVLP322 LIYFLFTRKN332 PYRFLWGIVT342 PLATAFGTSS 352 SSATLPLMMK362 CVEENNGVAK372 HISRFILPIG382 ATVNMDGAAL392 FQCVAAVFIA 402 QLSQQSLDFV412 KIITILVTAT422 ASSVGAAGIP432 AGGVLTLAII442 LEAVNLPVDH 452 ISLILAVDWL462 VDRSCTVLNV472 EGDALGAGLL482 QNYVDR
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SER351
3.916
SER352
3.351
SER353
2.487
SER354
4.293
MET387
4.695
ALA390
3.338
PHE393
4.974
ALA428
4.894
ALA429
3.390
GLY430
3.538
|
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| PDB ID: 6GCT cryo-EM structure of the human neutral amino acid transporter ASCT2 | ||||||
| Method | Electron microscopy | Resolution | 3.85 Å | Mutation | No | [2] |
| PDB Sequence |
DQVRRCLRAN
52 LLVLLTVVAV62 VAGVALGLGV72 SGAGGALALG82 PERLSAFVFP92 GELLLRLLRM 102 IILPLVVCSL112 IGGAASLDPG122 ALGRLGAWAL132 LFFLVTTLLA142 SALGVGLALA 152 LQPGAASAAS177 KEVLDSFLDL187 ARNIFPSNLV197 SAAFRSYSTT207 YEERNITGTR 217 VKVPVGQEVE227 GMNILGLVVF237 AIVFGVALRK247 LGPEGELLIR257 FFNSFNEATM 267 VLVSWIMWYA277 PVGIMFLVAG287 KIVEMEDVGL297 LFARLGKYIL307 CCLLGHAIHG 317 LLVLPLIYFL327 FTRKNPYRFL337 WGIVTPLATA347 FGTSSSSATL357 PLMMKCVEEN 367 NGVAKHISRF377 ILPIGATVNM387 DGAALFQCVA397 AVFIAQLSQQ407 SLDFVKIITI 417 LVTATASSVG427 AAGIPAGGVL437 TLAIILEAVN447 LPVDHISLIL457 AVDWLVDRSC 467 TVLNVEGDAL477 GAGLLQNYVD487 RT
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation. Elife. 2019 Oct 3;8:e48120. | ||||
| REF 2 | Cryo-EM structure of the human neutral amino acid transporter ASCT2. Nat Struct Mol Biol. 2018 Jun;25(6):515-521. | ||||
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