Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T55703 Target Info
Target Name Plasma retinol-binding protein (RBP4)
Synonyms Retinol-binding protein 4; RBP4; RBP; Plasma retinol-binding protein(1-176); PRBP
Target Type Clinical trial Target
Gene Name RBP4
Biochemical Class Calycin family
UniProt ID
RET4_HUMAN
Ligand General Information  Top
Ligand Name Oleic acid Ligand Info
Canonical SMILES CCCCCCCCC=CCCCCCCCC(=O)O
InChI 1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9-
InChIKey ZQPPMHVWECSIRJ-KTKRTIGZSA-N
PubChem Compound ID 445639
Drug Binding Sites of Target  Top
PDB ID: 2WQA      Complex of TTR and RBP4 and Oleic Acid
Method X-ray diffraction Resolution 2.85 Å Mutation No [1]
PDB Sequence
ERDCRVSSFR
10
VKENFDKARF
20
SGTWYAMAKK
30
DPEGLFLQDN
40
IVAEFSVDET
50

GQMSATAKGR
60
VRLLNNWDVC
70
ADMVGTFTDT
80
EDPAKFKMKY
90
WGVASFLQKG
100

NDDHWIVDTD
110
YDTYAVQYSC
120
RLLNLDGTCA
130
DSYSFVFSRD
140
PNGLPPEAQK
150

IVRQRQEELC
160
LARQYRLIVH
170
NGYCDG
Residue
Distance (Å)
LYS29
2.992
PRO32
3.544
GLY34
4.259
LEU35
3.339
PHE36
2.560
LEU37
2.775
ALA43
4.512
PHE45
3.736
ALA55
3.761
THR56
4.344
ALA57
3.566
MET73
3.609
VAL74
3.508
Residue
Distance (Å)
GLY75
3.573
PHE77
4.280
MET88
3.885
TYR90
3.519
GLN98
4.258
ASP102
4.665
HIS104
3.715
GLN117
3.761
ARG121
4.007
TYR133
3.534
PHE135
3.529
PHE137
3.830
PDB ID: 2WQ9      Crystal Structure of RBP4 bound to Oleic Acid
Method X-ray diffraction Resolution 1.65 Å Mutation No [2]
PDB Sequence
ERDCRVSSFR
10
VKENFDKARF
20
SGTWYAMAKK
30
DPEGLFLQDN
40
IVAEFSVDET
50

GQMSATAKGR
60
VRLLNWDVCA
71
DMVGTFTDTE
81
DPAKFKMKYW
91
GVASFLQKGN
101

DDHWIVDTDY
111
DTYAVQYSCR
121
LLNLDGTCAD
131
SYSFVFSRDP
141
NGLPPEAQKI
151

VRQRQEELCL
161
ARQYRLIVHN
171
GYC
Residue
Distance (Å)
LYS29
2.942
PRO32
3.448
GLY34
4.711
LEU35
3.580
PHE36
2.823
LEU37
2.864
ALA43
4.034
PHE45
3.611
ALA55
3.511
THR56
4.045
ALA57
3.768
MET73
3.726
VAL74
3.682
Residue
Distance (Å)
GLY75
3.615
PHE77
4.207
MET88
3.824
TYR90
3.470
GLN98
4.266
ASP102
4.640
HIS104
3.576
GLN117
3.424
ARG121
3.729
TYR133
3.702
PHE135
3.554
PHE137
3.574
References  Top
REF 1 Crystal Structure of Rbp4 Bound to Linoleic Acid and Ttr
REF 2 Crystal Structure of Rbp4 Bound to Oleic Acid

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