Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T55703 Target Info
Target Name Plasma retinol-binding protein (RBP4)
Synonyms Retinol-binding protein 4; RBP4; RBP; Plasma retinol-binding protein(1-176); PRBP
Target Type Clinical trial Target
Gene Name RBP4
Biochemical Class Calycin family
UniProt ID
RET4_HUMAN
Ligand General Information  Top
Ligand Name Lauric acid Ligand Info
Canonical SMILES CCCCCCCCCCCC(=O)O
InChI 1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)
InChIKey POULHZVOKOAJMA-UHFFFAOYSA-N
PubChem Compound ID 3893
Drug Binding Sites of Target  Top
PDB ID: 5NUA      Structure of human urine RBP4 saturated with laurate
Method X-ray diffraction Resolution 1.60 Å Mutation No [1]
PDB Sequence
ERDCRVSSFR
10
VKENFDKARF
20
SGTWYAMAKK
30
DPEGLFLQDN
40
IVAEFSVDET
50

GQMSATAKGR
60
VRLLNNWDVC
70
ADMVGTFTDT
80
EDPAKFKMKY
90
WGVASFLQKG
100

NDDHWIVDTD
110
YDTYAVQYSC
120
RLLNLDGTCA
130
DSYSFVFSRD
140
PNGLPPEAQK
150

IVRQRQEELC
160
LARQYRLIVH
170
NGYCD
Residue
Distance (Å)
LYS29
2.930
PRO32
3.526
GLY34
4.864
LEU35
3.767
PHE36
2.916
LEU37
3.029
ALA43
4.888
PHE45
4.565
ALA55
3.661
THR56
4.363
ALA57
3.177
MET73
4.181
Residue
Distance (Å)
VAL74
4.355
GLY75
4.399
PHE77
4.347
MET88
3.513
TYR90
3.748
GLN98
4.419
ASP102
4.735
HIS104
4.368
ARG121
3.768
TYR133
3.841
PHE135
4.037
PDB ID: 5NUB      Structure of human amniotic fluid RBP4 saturated with laurate
Method X-ray diffraction Resolution 1.60 Å Mutation No [1]
PDB Sequence
ERDCRVSSFR
10
VKENFDKARF
20
SGTWYAMAKK
30
DPEGLFLQDN
40
IVAEFSVDET
50

GQMSATAKGR
60
VRLLNNWDVC
70
ADMVGTFTDT
80
EDPAKFKMKY
90
WGVASFLQKG
100

NDDHWIVDTD
110
YDTYAVQYSC
120
RLLNLDGTCA
130
DSYSFVFSRD
140
PNGLPPEAQK
150

IVRQRQEELC
160
LARQYRLIVH
170
NGYCD
Residue
Distance (Å)
LYS29
2.915
PRO32
3.453
GLY34
4.864
LEU35
3.781
PHE36
2.972
LEU37
2.945
ALA43
4.320
PHE45
3.926
ALA55
4.266
ALA57
3.867
MET73
4.193
Residue
Distance (Å)
VAL74
4.596
GLY75
4.519
PHE77
4.426
MET88
3.454
TYR90
3.588
GLN98
4.851
HIS104
4.233
ARG121
3.747
TYR133
3.864
PHE135
4.066
PHE137
4.556
References  Top
REF 1 Human plasma retinol-binding protein (RBP4) is also a fatty acid-binding protein. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Apr;1863(4):458-466.

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