Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T55654 | Target Info | |||
| Target Name | cAMP-dependent chloride channel (CFTR) | ||||
| Synonyms | cAMPdependent chloride channel; Cystic fibrosis transmembrane conductance regulator; Channel conductancecontrolling ATPase; ATPbinding cassette subfamily C member 7; ATP-binding cassette sub-family C member 7; ABCC7 | ||||
| Target Type | Successful Target | ||||
| Gene Name | CFTR | ||||
| Biochemical Class | ABC transporter | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Ivacaftor | Ligand Info | |||
| Canonical SMILES | CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C | ||||
| InChI | 1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29) | ||||
| InChIKey | PURKAOJPTOLRMP-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 16220172 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 8EIQ The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with Trikafta [elexacaftor (VX-445), tezacaftor (VX-661), ivacaftor (VX-770)] and ATP/Mg | ||||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | Yes | [1] |
| PDB Sequence |
MQRSPLEKAS
10 VVSKLFFSWT20 RPILRKGYRQ30 RLELSDIYQI40 PSVDSADNLS50 EKLEREWDRE 60 LASKKNPKLI70 NALRRCFFWR80 FMFYGIFLYL90 GEVTKAVQPL100 LLGRIIASYD 110 PDNKEERSIA120 IYLGIGLCLL130 FIVRTLLLHP140 AIFGLHHIGM150 QMRIAMFSLI 160 YKKTLKLSSR170 VLDKISIGQL180 VSLLSNNLNK190 FDEGLALAHF200 VWIAPLQVAL 210 LMGLIWELLQ220 ASAFCGLGFL230 IVLALFQAGL240 GRMMMKYRDQ250 RAGKISERLV 260 ITSEMIENIQ270 SVKAYCWEEA280 MEKMIENLRQ290 TELKLTRKAA300 YVRYFNSSAF 310 FFSGFFVVFL320 SVLPYALIKG330 IILRKIFTTI340 SFCIVLRMAV350 TRQFPWAVQT 360 WYDSLGAINK370 IQDFLQKQEY380 KTLEYNLTTT390 EVVMENVTAF400 WEGTPVLKDI 444 NFKIERGQLL454 AVAGSTGAGK464 TSLLMVIMGE474 LEPSEGKIKH484 SGRISFCSQF 494 SWIMPGTIKE504 NIIGVSYDEY515 RYRSVIKACQ525 LEEDISKFAE535 KDNIVLGEGG 545 ITLSGGQRAR555 ISLARAVYKD565 ADLYLLDSPF575 GYLDVLTEKE585 IFESCVCKLM 595 ANKTRILVTS605 KMEHLKKADK615 ILILHEGSSY625 FYGTFSELQN635 LWNTYLRYIT 854 VHKSLIFVLI864 WCLVIFLAEV874 AASLVVLWLL884 GSYAVIITST910 SSYYVFYIYV 920 GVADTLLAMG930 FFRGLPLVHT940 LITVSKILHH950 KMLHSVLQAP960 MSTLNTLKAG 970 GILNRFSKDI980 AILDDLLPLT990 IFDFIQLLLI1000 VIGAIAVVAV1010 LQPYIFVATV 1020 PVIVAFIMLR1030 AYFLQTSQQL1040 KQLESEGRSP1050 IFTHLVTSLK1060 GLWTLRAFGR 1070 QPYFETLFHK1080 ALNLHTANWF1090 LYLSTLRWFQ1100 MRIEMIFVIF1110 FIAVTFISIL 1120 TTGEGEGRVG1130 IILTLAMNIM1140 STLQWAVNSS1150 IDVDSLMRSV1160 SRVFKFIDMP 1170 TEGIWPSGGQ1209 MTVKDLTAKY1219 TEGGNAILEN1229 ISFSISPGQR1239 VGLLGRTGSG 1249 KSTLLSAFLR1259 LLNTEGEIQI1269 DGVSWDSITL1279 QQWRKAFGVI1289 PQKVFIFSGT 1299 FRKNLDPYEQ1309 WSDQEIWKVA1319 DEVGLRSVIE1329 QFPGKLDFVL1339 VDGGCVLSHG 1349 HKQLMCLARS1359 VLSKAKILLL1369 DQPSAHLDPV1379 TYQIIRRTLK1389 QAFADCTVIL 1399 CEHRIEAMLE1409 CQQFLVIEEN1419 KVRQYDSIQK1429 LLNERSLFRQ1439 AISPSDRVKL 1449 FP
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| PDB ID: 6O2P Complex of ivacaftor with cystic fibrosis transmembrane conductance regulator (CFTR) | ||||||
| Method | Electron microscopy | Resolution | 3.30 Å | Mutation | Yes | [2] |
| PDB Sequence |
MQRSPLEKAS
10 VVSKLFFSWT20 RPILRKGYRQ30 RLELSDIYQI40 PSVDSADNLS50 EKLEREWDRE 60 LASKKNPKLI70 NALRRCFFWR80 FMFYGIFLYL90 GEVTKAVQPL100 LLGRIIASYD 110 PDNKEERSIA120 IYLGIGLCLL130 FIVRTLLLHP140 AIFGLHHIGM150 QMRIAMFSLI 160 YKKTLKLSSR170 VLDKISIGQL180 VSLLSNNLNK190 FDEGLALAHF200 VWIAPLQVAL 210 LMGLIWELLQ220 ASAFCGLGFL230 IVLALFQAGL240 GRMMMKYRDQ250 RAGKISERLV 260 ITSEMIENIQ270 SVKAYCWEEA280 MEKMIENLRQ290 TELKLTRKAA300 YVRYFNSSAF 310 FFSGFFVVFL320 SVLPYALIKG330 IILRKIFTTI340 SFCIVLRMAV350 TRQFPWAVQT 360 WYDSLGAINK370 IQDFLQKQEY380 KTLEYNLTTT390 EVVMENVTAF400 WEEGFGELFG 437 TPVLKDINFK447 IERGQLLAVA457 GSTGAGKTSL467 LMVIMGELEP477 SEGKIKHSGR 487 ISFCSQFSWI497 MPGTIKENII507 FGVSYDEYRY517 RSVIKACQLE527 EDISKFAEKD 537 NIVLGEGGIT547 LSGGQRARIS557 LARAVYKDAD567 LYLLDSPFGY577 LDVLTEKEIF 587 ESCVCKLMAN597 KTRILVTSKM607 EHLKKADKIL617 ILHEGSSYFY627 GTFSELQNLQ 637 TWNTYLRYIT854 VHKSLIFVLI864 WCLVIFLAEV874 AASLVVLWLL884 GNTPLNNSYA 904 VIITSTSSYY914 VFYIYVGVAD924 TLLAMGFFRG934 LPLVHTLITV944 SKILHHKMLH 954 SVLQAPMSTL964 NTLKAGGILN974 RFSKDIAILD984 DLLPLTIFDF994 IQLLLIVIGA 1004 IAVVAVLQPY1014 IFVATVPVIV1024 AFIMLRAYFL1034 QTSQQLKQLE1044 SEGRSPIFTH 1054 LVTSLKGLWT1064 LRAFGRQPYF1074 ETLFHKALNL1084 HTANWFLYLS1094 TLRWFQMRIE 1104 MIFVIFFIAV1114 TFISILTTGE1124 GEGRVGIILT1134 LAMNIMSTLQ1144 WAVNSSIDVD 1154 SLMRSVSRVF1164 KFIDMPTEGD1202 IWPSGGQMTV1212 KDLTAKYTEG1222 GNAILENISF 1232 SISPGQRVGL1242 LGRTGSGKST1252 LLSAFLRLLN1262 TEGEIQIDGV1272 SWDSITLQQW 1282 RKAFGVIPQK1292 VFIFSGTFRK1302 NLDPYEQWSD1312 QEIWKVADEV1322 GLRSVIEQFP 1332 GKLDFVLVDG1342 GCVLSHGHKQ1352 LMCLARSVLS1362 KAKILLLDQP1372 SAHLDPVTYQ 1382 IIRRTLKQAF1392 ADCTVILCEH1402 RIEAMLECQQ1412 FLVIEENKVR1422 QYDSIQKLLN 1432 ERSLFRQAIS1442 PSDRVKLFP
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Molecular structures reveal synergistic rescue of Delta508 CFTR by Trikafta modulators. Science. 2022 Oct 21;378(6617):284-290. | ||||
| REF 2 | Structural identification of a hotspot on CFTR for potentiation. Science. 2019 Jun 21;364(6446):1184-1188. | ||||
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