Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T54582 | Target Info | |||
| Target Name | Nicotinamide phosphoribosyltransferase (NAMPT) | ||||
| Synonyms | Visfatin; PreBcell colonyenhancing factor 1; PreB cellenhancing factor; Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; PBEF1; PBEF; Nampt; NAmPRTase | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | NAMPT | ||||
| Biochemical Class | Glycosyltransferases | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Benzamide | Ligand Info | |||
| Canonical SMILES | C1=CC=C(C=C1)C(=O)N | ||||
| InChI | 1S/C7H7NO/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H2,8,9) | ||||
| InChIKey | KXDAEFPNCMNJSK-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 2331 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 3DKL Crystal structure of phosphorylated mimic form of human NAMPT complexed with benzamide and phosphoribosyl pyrophosphate | ||||||
| Method | X-ray diffraction | Resolution | 1.89 Å | Mutation | No | [1] |
| PDB Sequence |
FNILLATDSY
18 KVTHYKQYPP28 NTSKVYSYFE38 CREYEETVFY60 GLQYILNKYL70 KGKVVTKEKI 80 QEAKDVYKEH90 FQDDVFNEKG100 WNYILEKYDG110 HLPIEIKAVP120 EGFVIPRGNV 130 LFTVENTDPE140 CYWLTNWIET150 ILVQSWYPIT160 VATNSREQKK170 ILAKYLLETS 180 GNLDGLEYKL190 HDFGYRGVSS200 QETAGIGASA210 HLVNFKGTDT220 VAGLALIKKY 230 YGTKDPVPGY240 SVPAAEHSTI250 TAWGKDHEKD260 AFEHIVTQFS270 SVPVSVVSDS 280 YDIYNACEKI290 WGEDLRHLIV300 SRSTQAPLII310 RPDSGNPLDT320 VLKVLEILGK 330 KFPVTENSKG340 YKLLPPYLRV350 IQGDGVDINT360 LQEIVEGMKQ370 KMWSIENIAF 380 GSGGGLLQKL390 TRDLLNCSFK400 CSYVVTNGLG410 INVFKDPVAD420 PNKRSKKGRL 430 SLHRTPAGNF440 VTLEEGKGDL450 EEYGQDLLHT460 VFKNGKVTKS470 YSFDEIRKNA 480 QLNI
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| PDB ID: 3DKJ Crystal structure of human NAMPT complexed with benzamide and phosphoribosyl pyrophosphate | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [1] |
| PDB Sequence |
FNILLATDSY
18 KVTHYKQYPP28 NTSKVYSYFE38 CREYEETVFY60 GLQYILNKYL70 KGKVVTKEKI 80 QEAKDVYKEH90 FQDDVFNEKG100 WNYILEKYDG110 HLPIEIKAVP120 EGFVIPRGNV 130 LFTVENTDPE140 CYWLTNWIET150 ILVQSWYPIT160 VATNSREQKK170 ILAKYLLETS 180 GNLDGLEYKL190 HDFGYRGVSS200 QETAGIGASA210 HLVNFKGTDT220 VAGLALIKKY 230 YGTKDPVPGY240 SVPAAEHSTI250 TAWGKDHEKD260 AFEHIVTQFS270 SVPVSVVSDS 280 YDIYNACEKI290 WGEDLRHLIV300 SRSTQAPLII310 RPDSGNPLDT320 VLKVLEILGK 330 KFPVTENSKG340 YKLLPPYLRV350 IQGDGVDINT360 LQEIVEGMKQ370 KMWSIENIAF 380 GSGGGLLQKL390 TRDLLNCSFK400 CSYVVTNGLG410 INVFKDPVAD420 PNKRSKKGRL 430 SLHRTPAGNF440 VTLEEGKGDL450 EEYGQDLLHT460 VFKNGKVTKS470 YSFDEIRKNA 480 QLNI
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13748-53. | ||||
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