Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T54582 | Target Info | |||
| Target Name | Nicotinamide phosphoribosyltransferase (NAMPT) | ||||
| Synonyms | Visfatin; PreBcell colonyenhancing factor 1; PreB cellenhancing factor; Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; PBEF1; PBEF; Nampt; NAmPRTase | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | NAMPT | ||||
| Biochemical Class | Glycosyltransferases | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Pyrophosphate 2- | Ligand Info | |||
| Canonical SMILES | OP(=O)([O-])OP(=O)(O)[O-] | ||||
| InChI | 1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-2 | ||||
| InChIKey | XPPKVPWEQAFLFU-UHFFFAOYSA-L | ||||
| PubChem Compound ID | 4995 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 3DHF Crystal structure of phosphorylated mimic form of human NAMPT complexed with nicotinamide mononucleotide and pyrophosphate | ||||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [1] |
| PDB Sequence |
FNILLATDSY
18 KVTHYKQYPP28 NTSKVYSYFE38 CREYEETVFY60 GLQYILNKYL70 KGKVVTKEKI 80 QEAKDVYKEH90 FQDDVFNEKG100 WNYILEKYDG110 HLPIEIKAVP120 EGFVIPRGNV 130 LFTVENTDPE140 CYWLTNWIET150 ILVQSWYPIT160 VATNSREQKK170 ILAKYLLETS 180 GNLDGLEYKL190 HDFGYRGVSS200 QETAGIGASA210 HLVNFKGTDT220 VAGLALIKKY 230 YGTKDPVPGY240 SVPAAEHSTI250 TAWGKDHEKD260 AFEHIVTQFS270 SVPVSVVSDS 280 YDIYNACEKI290 WGEDLRHLIV300 SRSTQAPLII310 RPDSGNPLDT320 VLKVLEILGK 330 KFPVTENSKG340 YKLLPPYLRV350 IQGDGVDINT360 LQEIVEGMKQ370 KMWSIENIAF 380 GSGGGLLQKL390 TRDLLNCSFK400 CSYVVTNGLG410 INVFKDPVAD420 PNKRSKKGRL 430 SLHRTPAGNF440 VTLEEGKGDL450 EEYGQDLLHT460 VFKNGKVTKS470 YSFDEIRKNA 480 QLNI
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| PDB ID: 3DHD Crystal structure of human NAMPT complexed with nicotinamide mononucleotide and pyrophosphate | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [1] |
| PDB Sequence |
FNILLATDSY
18 KVTHYKQYPP28 NTSKVYSYFE38 CREYEETVFY60 GLQYILNKYL70 KGKVVTKEKI 80 QEAKDVYKEH90 FQDDVFNEKG100 WNYILEKYDG110 HLPIEIKAVP120 EGFVIPRGNV 130 LFTVENTDPE140 CYWLTNWIET150 ILVQSWYPIT160 VATNSREQKK170 ILAKYLLETS 180 GNLDGLEYKL190 HDFGYRGVSS200 QETAGIGASA210 HLVNFKGTDT220 VAGLALIKKY 230 YGTKDPVPGY240 SVPAAEHSTI250 TAWGKDHEKD260 AFEHIVTQFS270 SVPVSVVSDS 280 YDIYNACEKI290 WGEDLRHLIV300 SRSTQAPLII310 RPDSGNPLDT320 VLKVLEILGK 330 KFPVTENSKG340 YKLLPPYLRV350 IQGDGVDINT360 LQEIVEGMKQ370 KMWSIENIAF 380 GSGGGLLQKL390 TRDLLNCSFK400 CSYVVTNGLG410 INVFKDPVAD420 PNKRSKKGRL 430 SLHRTPAGNF440 VTLEEGKGDL450 EEYGQDLLHT460 VFKNGKVTKS470 YSFDEIRKNA 480 QLNI
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| PDB ID: 4M6Q Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | ||||||
| Method | X-ray diffraction | Resolution | 2.41 Å | Mutation | No | [2] |
| PDB Sequence |
EFNILLATDS
17 YKVTHYKQYP27 PNTSKVYSYF37 ECREKKKYEE56 TVFYGLQYIL66 NKYLKGKVVT 76 KEKIQEAKDV86 YKEHFQDDVF96 NEKGWNYILE106 KYDGHLPIEI116 KAVPEGFVIP 126 RGNVLFTVEN136 TDPECYWLTN146 WIETILVQSW156 YPITVATNSR166 EQKKILAKYL 176 LETSGNLDGL186 EYKLHDFGYR196 GVSSQETAGI206 GASAHLVNFK216 GTDTVAGLAL 226 IKKYYGTKDP236 VPGYSVPAAE246 HSTITAWGKD256 HEKDAFEHIV266 TQFSSVPVSV 276 VSDSYDIYNA286 CEKIWGEDLR296 HLIVSRSTQA306 PLIIRPDSGN316 PLDTVLKVLE 326 ILGKKFPVTE336 NSKGYKLLPP346 YLRVIQGDGV356 DINTLQEIVE366 GMKQKMWSIE 376 NIAFGSGGGL386 LQKLTRDLLN396 CSFKCSYVVT406 NGLGINVFKD416 PVADPNKRSK 426 KGRLSLHRTP436 AGNFVTLEEG446 KGDLEEYGQD456 LLHTVFKNGK466 VTKSYSFDEI 476 RKNAQLNIEL486 E
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13748-53. | ||||
| REF 2 | Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett. 2013 Oct 15;23(20):5488-97. | ||||
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