Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T54582 | Target Info | |||
| Target Name | Nicotinamide phosphoribosyltransferase (NAMPT) | ||||
| Synonyms | Visfatin; PreBcell colonyenhancing factor 1; PreB cellenhancing factor; Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; PBEF1; PBEF; Nampt; NAmPRTase | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | NAMPT | ||||
| Biochemical Class | Glycosyltransferases | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | N-{4-[(3,5-Difluorophenyl)sulfonyl]benzyl}imidazo[1,2-A]pyridine-6-Carboxamide | Ligand Info | |||
| Canonical SMILES | C1=CC(=CC=C1CNC(=O)C2=CN3C=CN=C3C=C2)S(=O)(=O)C4=CC(=CC(=C4)F)F | ||||
| InChI | 1S/C21H15F2N3O3S/c22-16-9-17(23)11-19(10-16)30(28,29)18-4-1-14(2-5-18)12-25-21(27)15-3-6-20-24-7-8-26(20)13-15/h1-11,13H,12H2,(H,25,27) | ||||
| InChIKey | XRDVXQQZLHVEQZ-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 68277611 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 4KFO Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors | ||||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [1] |
| PDB Sequence |
EFNILLATDS
17 YKVTHYKQYP27 PNTSKVYSYF37 ECREKKVKYE55 ETVFYGLQYI65 LNKYLKGKVV 75 TKEKIQEAKD85 VYKEHFQDDV95 FNEKGWNYIL105 EKYDGHLPIE115 IKAVPEGFVI 125 PRGNVLFTVE135 NTDPECYWLT145 NWIETILVQS155 WYPITVATNS165 REQKKILAKY 175 LLETSGNLDG185 LEYKLHDFGY195 RGVSSQETAG205 IGASAHLVNF215 KGTDTVAGLA 225 LIKKYYGTKD235 PVPGYSVPAA245 EHSTITAWGK255 DHEKDAFEHI265 VTQFSSVPVS 275 VVSDSYDIYN285 ACEKIWGEDL295 RHLIVSRSTQ305 APLIIRPDSG315 NPLDTVLKVL 325 EILGKKFPVT335 ENSKGYKLLP345 PYLRVIQGDG355 VDINTLQEIV365 EGMKQKMWSI 375 ENIAFGSGGG385 LLQKLTRDLL395 NCSFKCSYVV405 TNGLGINVFK415 DPVADPNKRS 425 KKGRLSLHRT435 PAGNFVTLEE445 GKGDLEEYGQ455 DLLHTVFKNG465 KVTKSYSFDE 475 IRKNAQLNIE485 LE
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| PDB ID: 4O28 Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | Yes | [2] |
| PDB Sequence |
EFNILLATDS
17 YKVTHYKQYP27 PNTSKVYSYF37 ECREKYEETV58 FYGLQYILNK68 YLKGKVVTKE 78 KIQEAKDVYK88 EHFQDDVFNE98 KGWNYILEKY108 DGHLPIEIKA118 VPEGFVIPRG 128 NVLFTVENTD138 PECYWLTNWI148 ETILVQSWYP158 ITVATNFREQ168 KKILAKYLLE 178 TSGNLDGLEY188 KLHDFGYRGV198 SSQETAGIGA208 SAHLVNFKGT218 DTVAGLALIK 228 KYYGTKDPVP238 GYSVPAAEHS248 TITAWGKDHE258 KDAFEHIVTQ268 FSSVPVSVVS 278 DSYDIYNACE288 KIWGEDLRHL298 IVSRSTQAPL308 IIRPDSGNPL318 DTVLKVLEIL 328 GKKFPVTENS338 KGYKLLPPYL348 RVIQGDGVDI358 NTLQEIVEGM368 KQKMWSIENI 378 AFGSGQKLTR392 DLLNCSFKCS402 YVVTNGLGIN412 VFKDPVADPN422 KRSKKGRLSL 432 HRTPAGNFVT442 LEEGKGDLEE452 YGQDLLHTVF462 KNGKVTKSYS472 FDEIRKNAQL 482 NIELE
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors. J Med Chem. 2013 Jun 27;56(12):4921-37. | ||||
| REF 2 | Structural basis for resistance to diverse classes of NAMPT inhibitors. PLoS One. 2014 Oct 6;9(10):e109366. | ||||
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