Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T53612 | Target Info | |||
| Target Name | Kallikrein-6 (KLK6) | ||||
| Synonyms | Zyme; Serine protease 9; Serine protease 18; SP59; Protease M; PRSS9; PRSS18; Neurosin; MSP; K6 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | KLK6 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Benzamidine | Ligand Info | |||
| Canonical SMILES | C1=CC=C(C=C1)C(=N)N | ||||
| InChI | 1S/C7H8N2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H3,8,9) | ||||
| InChIKey | PXXJHWLDUBFPOL-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 2332 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 1LO6 Human Kallikrein 6 (hK6) active form with benzamidine inhibitor at 1.56 A resolution | ||||||
| Method | X-ray diffraction | Resolution | 1.56 Å | Mutation | No | [1] |
| PDB Sequence |
LVHGGPCDKT
25 SHPYQAALYT35 SGHLLCGGVL46 IHPLWVLTAA56 HCKKPNLQVF66 LGKHNLRQRE 77 SSQEQSSVVR87 AVIHPDYDAA97 SHDQDIMLLR107 LARPAKLSEL117 IQPLPLERDC 128 SANTTSCHIL139 GWGKTADGDF151 PDTIQCAYIH161 LVSREECEHA171 YPGQITQNML 181 CAGDEKYGKD189 SCQGDSGGPL199 VCGDHLRGLV213 SWGNIPCGSK222 EKPGVYTNVC 232 RYTNWIQKTI242 Q
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| PDB ID: 1L2E Human Kallikrein 6 (hK6) Active Form with benzamidine inhibitor | ||||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [2] |
| PDB Sequence |
LVHGGPCDKT
25 SHPYQAALYT35 SGHLLCGGVL46 IHPLWVLTAA56 HCKKPNLQVF66 LGKHNLRQRE 77 SSQEQSSVVR87 AVIHPDYDAA97 SHDQDIMLLR107 LARPAKLSEL117 IQPLPLERDC 128 SANTTSCHIL139 GWGKTADGDF151 PDTIQCAYIH161 LVSREECEHA171 YPGQITQNML 181 CAGDEKYGKD189 SCQGDSGGPL199 VCGDHLRGLV213 SWGNIPCGSK222 EKPGVYTNVC 232 RYTNWIQKTI242 Q
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure and biochemical characterization of human kallikrein 6 reveals a | ||||
| REF 2 | Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system. J Biol Chem. 2002 Jul 5;277(27):24562-70. | ||||
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