Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T52921 | Target Info | |||
| Target Name | Nociceptin receptor (OPRL1) | ||||
| Synonyms | Orphanin FQ receptor; Opioid-receptor-like 1; Opioid receptor like-1 receptor; Opioid receptor 4; ORL-1 receptor; ORL-1; OPRL1; OP(4); Kappa-type 3 opioid receptor; KOR-3 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | OPRL1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Oleic acid | Ligand Info | |||
| Canonical SMILES | CCCCCCCCC=CCCCCCCCC(=O)O | ||||
| InChI | 1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9- | ||||
| InChIKey | ZQPPMHVWECSIRJ-KTKRTIGZSA-N | ||||
| PubChem Compound ID | 445639 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 5DHG The crystal structure of nociceptin/orphanin FQ peptide receptor (NOP) in complex with C-35 (PSI Community Target) | ||||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | Yes | [1] |
| PDB Sequence |
PLGLKVTIVG
56 LYLAVCVGGL66 LGNCLVMYVI76 LRHTKMKTAT86 NIYIFNLALA96 DTLVLLTLPF 106 QGTDILLGFW116 PFGNALCKTV126 IAIDYYNMFT136 STFTLTAMSV146 DRYVAICHPI 156 VRTSSKAQAV170 NVAIWALASV180 VGVPVAIMGS190 AQVEDEEIEC200 LVEIPTPQDY 210 WGPVFAICIF220 LFSFIVPVLV230 ISVCYSLMIR240 RLRGVRLLSG250 SREKDRNLRR 260 ITRLVLVVVA270 VFVGCWTPVQ280 VFVLAQGLGV290 QPSSETAVAI300 LRFCTALGYV 310 NSCLNPILYA320 FLDENFKACF330 R
|
|||||
|
|
||||||
| PDB ID: 5DHH The crystal structure of nociceptin/orphanin FQ peptide receptor (NOP) in complex with SB-612111 (PSI Community Target) | ||||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | Yes | [1] |
| PDB Sequence |
FLPLGLKVTI
54 VGLYLAVCVG64 GLLGNCLVMY74 VILRHTKMKT84 ATNIYIFNLA94 LADTLVLLTL 104 PFQGTDILLG114 FWPFGNALCK124 TVIAIDYYNM134 FTSTFTLTAM144 SVDRYVAICH 154 PRTSSKAQAV170 NVAIWALASV180 VGVPVAIMGS190 AQVEDEEIEC200 LVEIPTPQDY 210 WGPVFAICIF220 LFSFIVPVLV230 ISVCYSLMIR240 RLRGVRLLSG250 SREKDRNLRR 260 ITRLVLVVVA270 VFVGCWTPVQ280 VFVLAQGLGV290 QPSSETAVAI300 LRFCTALGYV 310 NSCLNPILYA320 FLDENFKACF330 RK
|
|||||
|
|
VAL55
3.357
LEU59
4.190
ILE88
4.621
TYR89
3.181
PHE91
3.578
ASN92
4.201
LEU95
4.038
LEU104
4.631
PRO105
3.636
GLY108
4.463
THR109
3.407
LEU112
3.795
LEU113
4.071
PHE115
3.495
PRO117
3.826
ALA121
3.685
LYS124
3.237
THR125
3.968
|
|||||
| PDB ID: 4EA3 Structure of the N/OFQ Opioid Receptor in Complex with a Peptide Mimetic | ||||||
| Method | X-ray diffraction | Resolution | 3.01 Å | Mutation | Yes | [2] |
| PDB Sequence |
PLGLKVTIVG
56 LYLAVCVGGL66 LGNCLVMYVI76 LRHTKMKTAT86 NIYIFNLALA96 DTLVLLTLPF 106 QGTDILLGFW116 PFGNALCKTV126 IAIDYYNMFT136 STFTLTAMSV146 DRYVAICHPT 163 SSKAQAVNVA173 IWALASVVGV183 PVAIMGSAQV193 EDEEIECLVE203 IPTPQDYWGP 213 VFAICIFLFS223 FIVPVLVISV233 CYSLMIRRLR243 GVRLLSGSRE253 KDRNLRRITR 263 LVLVVVAVFV273 GCWTPVQVFV283 LAQGLGVQPS293 SETAVAILRF303 CTALGYVNSC 313 LNPILYAFLD323 ENFKACFR
|
|||||
|
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor. Structure. 2015 Dec 1;23(12):2291-2299. | ||||
| REF 2 | Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature. 2012 May 16;485(7398):395-9. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.