Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T49453 Target Info
Target Name Notch-4 receptor (NOTCH4)
Synonyms hNotch4; Notch 4; Neurogenic locus notch homolog protein 4; INT3
Target Type Clinical trial Target
Gene Name NOTCH4
Biochemical Class Notch protein
UniProt ID
NOTC4_HUMAN
Ligand General Information  Top
Ligand Name L-serine-O-phosphate Ligand Info
Canonical SMILES C(C(C(=O)O)N)OP(=O)(O)O
InChI 1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
InChIKey BZQFBWGGLXLEPQ-REOHCLBHSA-N
PubChem Compound ID 68841
Drug Binding Sites of Target  Top
PDB ID: 7OR3      Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ136
Method X-ray diffraction Resolution 1.80 Å Mutation No [1]
PDB Sequence
RRFAGMR
Residue
Distance (Å)
ARG1914
4.153
ARG1915
1.882
PHE1916
1.333
ALA1918
1.328
Residue
Distance (Å)
GLY1919
2.558
MET1920
2.323
ARG1921
3.660
PDB ID: 7OR5      Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ162
Method X-ray diffraction Resolution 1.80 Å Mutation No [2]
PDB Sequence
RRFAGM
Residue
Distance (Å)
ARG1914
4.072
ARG1915
1.921
PHE1916
1.325
Residue
Distance (Å)
ALA1918
1.329
GLY1919
3.108
MET1920
2.163
PDB ID: 7OR7      Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ178
Method X-ray diffraction Resolution 1.80 Å Mutation No [3]
PDB Sequence
RRFAGMR
Residue
Distance (Å)
ARG1914
3.999
ARG1915
1.912
PHE1916
1.331
ALA1918
1.325
Residue
Distance (Å)
GLY1919
2.954
MET1920
2.202
ARG1921
3.377
References  Top
REF 1 A crystallography-based study of fragment extensions
REF 2 A crystallography-based study of fragment extensions
REF 3 A crystallography-based study of fragment extensions

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