Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T48703 | Target Info | |||
| Target Name | Toll-like receptor 8 (TLR8) | ||||
| Synonyms | UNQ249/PRO286; CD288 antigen; CD288 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | TLR8 | ||||
| Biochemical Class | Toll-like receptor | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Uridine | Ligand Info | |||
| Canonical SMILES | C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O | ||||
| InChI | 1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 | ||||
| InChIKey | DRTQHJPVMGBUCF-XVFCMESISA-N | ||||
| PubChem Compound ID | 6029 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 4R0A Crystal structure of human TLR8 in complex with uridine mononucleoside | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [1] |
| PDB Sequence |
RSYPCDEKKQ
41 NDSVIAECSN51 RRLQEVPQTV61 GKYVTELDLS71 DNFITHITNE81 SFQGLQNLTK 91 INLNHNPNVG113 LNITDGAFLN123 LKNLRELLLE133 DNQLPQIPSG143 LPESLTELSL 153 IQNNIYNITK163 EGISRLINLK173 NLYLAWNCYF183 NKVCEKTNIE193 DGVFETLTNL 203 ELLSLSFNSL213 SHVPPKLPSS223 LRKLFLSNTQ233 IKYISEEDFK243 GLINLTLLDL 253 SGNCPRCFNA263 PFPCVPCDGG273 ASINIDRFAF283 QNLTQLRYLN293 LSSTSLRKIN 303 AAWFKNMPHL313 KVLDLEFNYL323 VGEIASGAFL333 TMLPRLEILD343 LSFNYIKGSY 353 PQHINISRNF363 SKLLSLRALH373 LRGYVFQELR383 EDDFQPLMQL393 PNLSTINLGI 403 NFIKQIDFKL413 FQNFSNLEII423 YLSENRISPL433 EFDPHSNFYH469 FTRPLIKPQC 479 AAYGKALDLS489 LNSIFFIGPN499 QFENLPDIAC509 LNLSANSNAQ519 VLSGTEFSAI 529 PHVKYLDLTN539 NRLDFDNASA549 LTELSDLEVL559 DLSYNSHYFR569 IAGVTHHLEF 579 IQNFTNLKVL589 NLSHNNIYTL599 TDKYNLESKS609 LVELVFSGNR619 LDILWNDDDN 629 RYISIFKGLK639 NLTRLDLSLN649 RLKHIPNEAF659 LNLPASLTEL669 HINDNMLKFF 679 NWTLLQQFPR689 LELLDLRGNK699 LLFLTDSLSD709 FTSSLRTLLL719 SHNRISHLPS 729 GFLSEVSSLK739 HLDLSSNLLK749 TINKSALETK759 TTTKLSMLEL769 HGNPFECTCD 779 IGDFRRWMDE789 HLNVKIPRLV799 DVICASPGDQ809 RGKSIVSL
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| PDB ID: 4R07 Crystal structure of human TLR8 in complex with ORN06 | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [1] |
| PDB Sequence |
RSYPCDEKVI
46 AECSNRRLQE56 VPQTVGKYVT66 ELDLSDNFIT76 HITNESFQGL86 QNLTKINLNH 96 NPNVNGLNIT117 DGAFLNLKNL127 RELLLEDNQL137 PQIPSGLPES147 LTELSLIQNN 157 IYNITKEGIS167 RLINLKNLYL177 AWNCYFNKVC187 EKTNIEDGVF197 ETLTNLELLS 207 LSFNSLSHVP217 PKLPSSLRKL227 FLSNTQIKYI237 SEEDFKGLIN247 LTLLDLSGNC 257 PRCFNAPFPC267 VPCDGGASIN277 IDRFAFQNLT287 QLRYLNLSST297 SLRKINAAWF 307 KNMPHLKVLD317 LEFNYLVGEI327 ASGAFLTMLP337 RLEILDLSFN347 YIKGSYPQHI 357 NISRNFSKLL367 SLRALHLRGY377 VFQELREDDF387 QPLMQLPNLS397 TINLGINFIK 407 QIDFKLFQNF417 SNLEIIYLSE427 NRISPTDFEF461 DPHSNFYHFT471 RPLIKPQCAA 481 YGKALDLSLN491 SIFFIGPNQF501 ENLPDIACLN511 LSANSNAQVL521 SGTEFSAIPH 531 VKYLDLTNNR541 LDFDNASALT551 ELSDLEVLDL561 SYNSHYFRIA571 GVTHHLEFIQ 581 NFTNLKVLNL591 SHNNIYTLTD601 KYNLESKSLV611 ELVFSGNRLD621 ILWNDDDNRY 631 ISIFKGLKNL641 TRLDLSLNRL651 KHIPNEAFLN661 LPASLTELHI671 NDNMLKFFNW 681 TLLQQFPRLE691 LLDLRGNKLL701 FLTDSLSDFT711 SSLRTLLLSH721 NRISHLPSGF 731 LSEVSSLKHL741 DLSSNLLKTI751 NKSALETKTT761 TKLSMLELHG771 NPFECTCDIG 781 DFRRWMDEHL791 NVKIPRLVDV801 ICASPGDQRG811 KSIVSLE
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| PDB ID: 4R08 Crystal structure of human TLR8 in complex with ssRNA40 | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [1] |
| PDB Sequence |
RSYPCDEKKQ
40 VIAECSNRRL54 QEVPQTVGKY64 VTELDLSDNF74 ITHITNESFQ84 GLQNLTKINL 94 NHNPNVNGLN115 ITDGAFLNLK125 NLRELLLEDN135 QLPQIPSGLP145 ESLTELSLIQ 155 NNIYNITKEG165 ISRLINLKNL175 YLAWNCYFNK185 VCEKTNIEDG195 VFETLTNLEL 205 LSLSFNSLSH215 VPPKLPSSLR225 KLFLSNTQIK235 YISEEDFKGL245 INLTLLDLSG 255 NCPRCFNAPF265 PCVPCDGGAS275 INIDRFAFQN285 LTQLRYLNLS295 STSLRKINAA 305 WFKNMPHLKV315 LDLEFNYLVG325 EIASGAFLTM335 LPRLEILDLS345 FNYIKGSYPQ 355 HINISRNFSK365 LLSLRALHLR375 GYVFQELRED385 DFQPLMQLPN395 LSTINLGINF 405 IKQIDFKLFQ415 NFSNLEIIYL425 SENRISPDFE460 FDPHSNFYHF470 TRPLIKPQCA 480 AYGKALDLSL490 NSIFFIGPNQ500 FENLPDIACL510 NLSANSNAQV520 LSGTEFSAIP 530 HVKYLDLTNN540 RLDFDNASAL550 TELSDLEVLD560 LSYNSHYFRI570 AGVTHHLEFI 580 QNFTNLKVLN590 LSHNNIYTLT600 DKYNLESKSL610 VELVFSGNRL620 DILWNDDDNR 630 YISIFKGLKN640 LTRLDLSLNR650 LKHIPNEAFL660 NLPASLTELH670 INDNMLKFFN 680 WTLLQQFPRL690 ELLDLRGNKL700 LFLTDSLSDF710 TSSLRTLLLS720 HNRISHLPSG 730 FLSEVSSLKH740 LDLSSNLLKT750 INKSALEKLS765 MLELHGNPFE775 CTCDIGDFRR 785 WMDEHLNVKI795 PRLVDVICAS805 PGDQRGKSIV815 SLE
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| PDB ID: 4R09 Crystal structure of human TLR8 in complex with ORN06S | ||||||
| Method | X-ray diffraction | Resolution | 2.62 Å | Mutation | No | [1] |
| PDB Sequence |
RSYPCDEKKQ
40 VIAECSNRRL54 QEVPQTVGKY64 VTELDLSDNF74 ITHITNESFQ84 GLQNLTKINL 94 NHNPNVGLNI116 TDGAFLNLKN126 LRELLLEDNQ136 LPQIPSGLPE146 SLTELSLIQN 156 NIYNITKEGI166 SRLINLKNLY176 LAWNCYFNKV186 CEKTNIEDGV196 FETLTNLELL 206 SLSFNSLSHV216 PPKLPSSLRK226 LFLSNTQIKY236 ISEEDFKGLI246 NLTLLDLSGN 256 CPRCFNAPFP266 CVPCDGGASI276 NIDRFAFQNL286 TQLRYLNLSS296 TSLRKINAAW 306 FKNMPHLKVL316 DLEFNYLVGE326 IASGAFLTML336 PRLEILDLSF346 NYIKGSYPQH 356 INISRNFSKL366 LSLRALHLRG376 YVFQELREDD386 FQPLMQLPNL396 STINLGINFI 406 KQIDFKLFQN416 FSNLEIIYLS426 ENRISPLDFE460 FDPHSNFYHF470 TRPLIKPQCA 480 AYGKALDLSL490 NSIFFIGPNQ500 FENLPDIACL510 NLSANSNAQV520 LSGTEFSAIP 530 HVKYLDLTNN540 RLDFDNASAL550 TELSDLEVLD560 LSYNSHYFRI570 AGVTHHLEFI 580 QNFTNLKVLN590 LSHNNIYTLT600 DKYNLESKSL610 VELVFSGNRL620 DILWNDDDNR 630 YISIFKGLKN640 LTRLDLSLNR650 LKHIPNEAFL660 NLPASLTELH670 INDNMLKFFN 680 WTLLQQFPRL690 ELLDLRGNKL700 LFLTDSLSDF710 TSSLRTLLLS720 HNRISHLPSG 730 FLSEVSSLKH740 LDLSSNLLKT750 INKSALETKT760 TTKLSMLELH770 GNPFECTCDI 780 GDFRRWMDEH790 LNVKIPRLVD800 VICASPGDQR810 GKSIVSLEL
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Click to Show 3D Structure of This Binding Site
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Toll-like receptor 8 senses degradation products of single-stranded RNA. Nat Struct Mol Biol. 2015 Feb;22(2):109-15. | ||||
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