Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T48330 | Target Info | |||
| Target Name | Large neutral amino acids transporter 1 (SLC7A5) | ||||
| Synonyms | y+ system cationic amino acid transporter; Solute carrier family 7 member 5; MPE16; Large neutral amino acids transporter small subunit 1; LAT1; L-type amino acid transporter LAT1; L-type amino acid transporter 1; Integral membrane protein E16; HLAT1; CD98LC; CD98 light chain; 4F2LC; 4F2 light chain; 4F2 LC | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SLC7A5 | ||||
| Biochemical Class | Amino acid-polyamine-organocation | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Cholesterol hemisuccinate | Ligand Info | |||
| Canonical SMILES | CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)CCC(=O)O)C)C | ||||
| InChI | 1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1 | ||||
| InChIKey | WLNARFZDISHUGS-MIXBDBMTSA-N | ||||
| PubChem Compound ID | 65082 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7DSK Overall structure of the LAT1-4F2hc bound with JX-075 | ||||||
| Method | Electron microscopy | Resolution | 2.90 Å | Mutation | No | [1] |
| PDB Sequence |
VTLQRNITLL
53 NGVAIIVGTI63 IGSGIFVTPT73 GVLKEAGSPG83 LALVVWAACG93 VFSIVGALCY 103 AELGTTISKS113 GGDYAYMLEV123 YGSLPAFLKL133 WIELLIIRPS143 SQYIVALVFA 153 TYLLKPLFPT163 CPVPEEAAKL173 VACLCVLLLT183 AVNCYSVKAA193 TRVQDAFAAA 203 KLLALALIIL213 LGFVQIGKGD223 VSNLDPNFSF233 EGTKLDVGNI243 VLALYSGLFA 253 YGGWNYLNFV263 TEEMINPYRN273 LPLAIIISLP283 IVTLVYVLTN293 LAYFTTLSTE 303 QMLSSEAVAV313 DFGNYHLGVM323 SWIIPVFVGL333 SCFGSVNGSL343 FTSSRLFFVG 353 SREGHLPSIL363 SMIHPQLLTP373 VPSLVFTCVM383 TLLYAFSKDI393 FSVINFFSFF 403 NWLCVALAII413 GMIWLRHRKP423 ELERPIKVNL433 ALPVFFILAC443 LFLIAVSFWK 453 TPVECGIGFT463 IILSGLPVYF473 FGVWWKNKPK483 WLLQGIFSTT493 VLCQKLMQVV 503 PQET
|
|||||
|
|
LEU181
4.802
VAL185
4.323
TYR188
3.975
SER189
4.384
LYS191
2.670
ALA192
3.620
ARG195
4.151
VAL196
3.674
ALA199
4.559
PHE200
3.690
|
|||||
| PDB ID: 7DSL Overall structure of the LAT1-4F2hc bound with JX-078 | ||||||
| Method | Electron microscopy | Resolution | 2.90 Å | Mutation | No | [1] |
| PDB Sequence |
VTLQRNITLL
53 NGVAIIVGTI63 IGSGIFVTPT73 GVLKEAGSPG83 LALVVWAACG93 VFSIVGALCY 103 AELGTTISKS113 GGDYAYMLEV123 YGSLPAFLKL133 WIELLIIRPS143 SQYIVALVFA 153 TYLLKPLFPT163 CPVPEEAAKL173 VACLCVLLLT183 AVNCYSVKAA193 TRVQDAFAAA 203 KLLALALIIL213 LGFVQIGKGD223 VSNLDPNFSF233 EGTKLDVGNI243 VLALYSGLFA 253 YGGWNYLNFV263 TEEMINPYRN273 LPLAIIISLP283 IVTLVYVLTN293 LAYFTTLSTE 303 QMLSSEAVAV313 DFGNYHLGVM323 SWIIPVFVGL333 SCFGSVNGSL343 FTSSRLFFVG 353 SREGHLPSIL363 SMIHPQLLTP373 VPSLVFTCVM383 TLLYAFSKDI393 FSVINFFSFF 403 NWLCVALAII413 GMIWLRHRKP423 ELERPIKVNL433 ALPVFFILAC443 LFLIAVSFWK 453 TPVECGIGFT463 IILSGLPVYF473 FGVWWKNKPK483 WLLQGIFSTT493 VLCQKLMQVV 503 PQET
|
|||||
|
|
||||||
| PDB ID: 7DSN Overall structure of the LAT1-4F2hc bound with JX-119 | ||||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | No | [1] |
| PDB Sequence |
VTLQRNITLL
53 NGVAIIVGTI63 IGSGIFVTPT73 GVLKEAGSPG83 LALVVWAACG93 VFSIVGALCY 103 AELGTTISKS113 GGDYAYMLEV123 YGSLPAFLKL133 WIELLIIRPS143 SQYIVALVFA 153 TYLLKPLFPT163 CPVPEEAAKL173 VACLCVLLLT183 AVNCYSVKAA193 TRVQDAFAAA 203 KLLALALIIL213 LGFVQIGKGD223 VSNLDPNFSF233 EGTKLDVGNI243 VLALYSGLFA 253 YGGWNYLNFV263 TEEMINPYRN273 LPLAIIISLP283 IVTLVYVLTN293 LAYFTTLSTE 303 QMLSSEAVAV313 DFGNYHLGVM323 SWIIPVFVGL333 SCFGSVNGSL343 FTSSRLFFVG 353 SREGHLPSIL363 SMIHPQLLTP373 VPSLVFTCVM383 TLLYAFSKDI393 FSVINFFSFF 403 NWLCVALAII413 GMIWLRHRKP423 ELERPIKVNL433 ALPVFFILAC443 LFLIAVSFWK 453 TPVECGIGFT463 IILSGLPVYF473 FGVWWKNKPK483 WLLQGIFSTT493 VLCQKLMQVV 503 PQET
|
|||||
|
|
PHE152
3.648
LEU156
4.979
LEU181
4.088
VAL185
3.790
TYR188
3.550
SER189
3.608
LYS191
2.412
ALA192
3.818
ARG195
2.771
VAL196
3.670
PHE200
4.492
|
|||||
| PDB ID: 7DSQ Overall structure of the LAT1-4F2hc bound with 3,5-diiodo-L-tyrosine | ||||||
| Method | Electron microscopy | Resolution | 3.40 Å | Mutation | No | [1] |
| PDB Sequence |
VTLQRNITLL
53 NGVAIIVGTI63 IGSGIFVTPT73 GVLKEAGSPG83 LALVVWAACG93 VFSIVGALCY 103 AELGTTISKS113 GGDYAYMLEV123 YGSLPAFLKL133 WIELLIIRPS143 SQYIVALVFA 153 TYLLKPLFPT163 CPVPEEAAKL173 VACLCVLLLT183 AVNCYSVKAA193 TRVQDAFAAA 203 KLLALALIIL213 LGFVQIGKGD223 VSNLDPNFSF233 EGTKLDVGNI243 VLALYSGLFA 253 YGGWNYLNFV263 TEEMINPYRN273 LPLAIIISLP283 IVTLVYVLTN293 LAYFTTLSTE 303 QMLSSEAVAV313 DFGNYHLGVM323 SWIIPVFVGL333 SCFGSVNGSL343 FTSSRLFFVG 353 SREGHLPSIL363 SMIHPQLLTP373 VPSLVFTCVM383 TLLYAFSKDI393 FSVINFFSFF 403 NWLCVALAII413 GMIWLRHRKP423 ELERPIKVNL433 ALPVFFILAC443 LFLIAVSFWK 453 TPVECGIGFT463 IILSGLPVYF473 FGVWWKNKPK483 WLLQGIFSTT493 VLCQKLMQVV 503 PQET
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Y01 or .Y012 or .Y013 or :3Y01;style chemicals stick;color identity;select .B:152 or .B:156 or .B:181 or .B:185 or .B:188 or .B:189 or .B:191 or .B:192 or .B:196 or .B:200 or .B:333 or .B:336 or .B:367 or .B:369 or .B:370 or .B:374 or .B:378 or .B:499 or .B:500 or .B:501; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
PHE152
3.904
LEU156
4.936
LEU181
4.939
VAL185
3.981
TYR188
3.225
SER189
4.514
LYS191
3.312
ALA192
3.725
VAL196
3.756
PHE200
3.641
|
|||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter. Cell Discov. 2021 Mar 23;7(1):16. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.