Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T47510 Target Info
Target Name Angiomotin (AMOT)
Synonyms KIAA1071
Target Type Literature-reported Target
Gene Name AMOT
UniProt ID
AMOT_HUMAN
Ligand General Information  Top
Ligand Name L-serine-O-phosphate Ligand Info
Canonical SMILES C(C(C(=O)O)N)OP(=O)(O)O
InChI 1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
InChIKey BZQFBWGGLXLEPQ-REOHCLBHSA-N
PubChem Compound ID 68841
Drug Binding Sites of Target  Top
PDB ID: 7NPB      Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide and fragment 09
Method X-ray diffraction Resolution 1.37 Å Mutation No [1]
PDB Sequence
VRSLERLM
Residue
Distance (Å)
SER173
3.715
LEU174
1.330
Residue
Distance (Å)
GLU176
1.327
ARG177
2.924
PDB ID: 7NPG      Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide and fragment 22
Method X-ray diffraction Resolution 1.37 Å Mutation No [1]
PDB Sequence
RSLERLM
Residue
Distance (Å)
SER173
3.730
LEU174
1.330
Residue
Distance (Å)
GLU176
1.329
ARG177
3.412
PDB ID: 7OQS      Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ177
Method X-ray diffraction Resolution 1.34 Å Mutation No [2]
PDB Sequence
VRSLERL
Residue
Distance (Å)
SER173
3.755
LEU174
1.330
Residue
Distance (Å)
GLU176
1.321
ARG177
2.681
PDB ID: 7NND      Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 09
Method X-ray diffraction Resolution 1.40 Å Mutation No [1]
PDB Sequence
RSLERLMQ
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .P:173 or .P:174 or .P:176 or .P:177; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
SER173
3.722
LEU174
1.332
Residue
Distance (Å)
GLU176
1.330
ARG177
3.004
PDB ID: 7OQJ      Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ162
Method X-ray diffraction Resolution 1.40 Å Mutation No [3]
PDB Sequence
RSLER
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .P:173 or .P:174 or .P:176 or .P:177; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
SER173
3.862
LEU174
1.329
Residue
Distance (Å)
GLU176
1.325
ARG177
2.894
PDB ID: 7OQU      Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ180
Method X-ray diffraction Resolution 1.40 Å Mutation No [4]
PDB Sequence
RSLER
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .P:173 or .P:174 or .P:176 or .P:177; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
SER173
3.742
LEU174
1.329
Residue
Distance (Å)
GLU176
1.325
ARG177
2.889
PDB ID: 7NMW      Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 40
Method X-ray diffraction Resolution 1.50 Å Mutation No [1]
PDB Sequence
RSLERL
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .P:173 or .P:174 or .P:176 or .P:177; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
SER173
3.704
LEU174
1.334
Residue
Distance (Å)
GLU176
1.327
ARG177
2.766
PDB ID: 7OQG      Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ136
Method X-ray diffraction Resolution 1.50 Å Mutation No [5]
PDB Sequence
RSLER
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .P:173 or .P:174 or .P:176 or .P:177; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
SER173
3.833
LEU174
1.332
Residue
Distance (Å)
GLU176
1.325
ARG177
2.810
PDB ID: 7NN2      Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 41
Method X-ray diffraction Resolution 1.80 Å Mutation No [1]
PDB Sequence
RSLERL
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .P:173 or .P:174 or .P:176 or .P:177; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
SER173
3.713
LEU174
1.333
Residue
Distance (Å)
GLU176
1.321
ARG177
2.976
PDB ID: 7OQW      Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ178
Method X-ray diffraction Resolution 1.90 Å Mutation No [6]
PDB Sequence
SLER
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .P:173 or .P:174 or .P:176 or .P:177; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
SER173
3.645
LEU174
1.327
Residue
Distance (Å)
GLU176
1.331
ARG177
2.967
PDB ID: 7NNE      Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 22
Method X-ray diffraction Resolution 1.96 Å Mutation No [1]
PDB Sequence
HVRSLERLMQ
180
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .P:173 or .P:174 or .P:176 or .P:177; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
SER173
3.701
LEU174
1.328
Residue
Distance (Å)
GLU176
1.328
ARG177
2.157
PDB ID: 7NMX      Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 12
Method X-ray diffraction Resolution 2.30 Å Mutation No [1]
PDB Sequence
RSLERL
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .P:173 or .P:174 or .P:176 or .P:177; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
SER173
3.741
LEU174
1.332
Residue
Distance (Å)
GLU176
1.330
ARG177
2.364
References  Top
REF 1 Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol. 2021 Dec 29;4:21-28.
REF 2 A crystallography-based study of fragment extensions
REF 3 A crystallography-based study of fragment extensions into the 14-3-3 binding groove
REF 4 A crystallography-based study of fragment extensions
REF 5 A crystallography-based study of fragment extensions into the 14-3-3 binding groove
REF 6 A crystallography-based study of fragment extensions

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