Target Binding Site Detail
Target General Information | Top | ||||
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Target ID | T47510 | Target Info | |||
Target Name | Angiomotin (AMOT) | ||||
Synonyms | KIAA1071 | ||||
Target Type | Literature-reported Target | ||||
Gene Name | AMOT | ||||
UniProt ID |
Ligand General Information | Top | ||||
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Ligand Name | 5-[1-(2-Azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide | Ligand Info | |||
Canonical SMILES | C1=CC=C(C=C1)C2=C(SC(=C2)C(=N)N)C3=CN(C=N3)CCN | ||||
InChI | 1S/C16H17N5S/c17-6-7-21-9-13(20-10-21)15-12(8-14(22-15)16(18)19)11-4-2-1-3-5-11/h1-5,8-10H,6-7,17H2,(H3,18,19) | ||||
InChIKey | GUDUPRUYKRGSAE-UHFFFAOYSA-N | ||||
PubChem Compound ID | 146170558 |
Drug Binding Sites of Target | Top | |||||
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PDB ID: 7NPB Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide and fragment 09 | ||||||
Method | X-ray diffraction | Resolution | 1.37 Å | Mutation | No | [1] |
PDB Sequence |
VRSLERLM
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PDB ID: 7NND Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 09 | ||||||
Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [1] |
PDB Sequence |
RSLERLMQ
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References | Top | ||||
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REF 1 | Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol. 2021 Dec 29;4:21-28. |
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