Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T40909 | Target Info | |||
| Target Name | Rhinovirus Protease 3C (HRV P3C) | ||||
| Synonyms | Rhinovirus P3C | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | HRV P3C | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Lauric acid | Ligand Info | |||
| Canonical SMILES | CCCCCCCCCCCC(=O)O | ||||
| InChI | 1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14) | ||||
| InChIKey | POULHZVOKOAJMA-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 3893 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 1FPN HUMAN RHINOVIRUS SEROTYPE 2 (HRV2) | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [1] |
| PDB Sequence |
LVVPNINSSN
24 PTTSNSAPAL34 DAAETGHTSS44 VQPEDVIETR54 YVQTSQTRDE64 MSLESFLGRS 74 GCIHESKLEV84 TLANYNKENF94 TVWAINLQEM104 AQIRRKFELF114 TYTRFDSEIT 124 LVPCISALSQ134 DIGHITMQYM144 YVPPGAPVPN154 SRDDYAWQSG164 TNASVFWQHG 174 QAYPRFSLPF184 LSVASAYYMF194 YDGYDEQDQN204 YGTANTNNMG214 SLCSRIVTEK 224 HIHKVHIMTR234 IYHKAKHVKA244 WCPRPPRALE254 YTRAHRTNFK264 IEDRSIQTAI 274 VTRPIITTA
|
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|
|
ILE77
4.640
TRP97
4.783
ILE99
3.349
ASN100
3.561
LEU101
3.184
GLN102
3.032
PHE119
4.772
SER121
3.804
ILE123
3.686
TYR145
4.104
PHE180
4.648
|
|||||
| PDB ID: 3DPR Human rhinovirus 2 bound to a concatamer of the VLDL receptor module V3 | ||||||
| Method | X-ray diffraction | Resolution | 3.50 Å | Mutation | No | [2] |
| PDB Sequence |
LVVPNINSSN
24 PTTSNSAPAL34 DAAETGHTSS44 VQPEDVIETR54 YVQTSQTRDE64 MSLESFLGRS 74 GCIHESKLEV84 TLANYNKENF94 TVWAINLQEM104 AQIRRKFELF114 TYTRFDSEIT 124 LVPCISALSQ134 DIGHITMQYM144 YVPPGAPVPN154 SRDDYAWQSG164 TNASVFWQHG 174 QAYPRFSLPF184 LSVASAYYMF194 YDGYDEQDQN204 YGTANTNNMG214 SLCSRIVTEK 224 HIHKVHIMTR234 IYHKAKHVKA244 WCPRPPRALE254 YTRAHRTNFK264 IEDRSIQTAI 274 VTRPIITTA
|
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|
|
ILE99
3.360
ASN100
3.569
LEU101
2.673
GLN102
3.557
PHE119
4.609
SER121
3.961
ILE123
3.667
TYR145
3.695
PHE180
3.971
LEU182
4.091
|
|||||
| PDB ID: 1V9U Human Rhinovirus 2 bound to a fragment of its cellular receptor protein | ||||||
| Method | X-ray diffraction | Resolution | 3.60 Å | Mutation | No | [3] |
| PDB Sequence |
LVVPNINSSN
24 PTTSNSAPAL34 DAAETGHTSS44 VQPEDVIETR54 YVQTSQTRDE64 MSLESFLGRS 74 GCIHESKLEV84 TLANYNKENF94 TVWAINLQEM104 AQIRRKFELF114 TYTRFDSEIT 124 LVPCISALSQ134 DIGHITMQYM144 YVPPGAPVPN154 SRDDYAWQSG164 TNASVFWQHG 174 QAYPRFSLPF184 LSVASAYYMF194 YDGYDEQDQN204 YGTANTNNMG214 SLCSRIVTEK 224 HIHKVHIMTR234 IYHKAKHVKA244 WCPRPPRALE254 YTRAHRTNFK264 IEDRSIQTAI 274 VTRPIITTA
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of human rhinovirus serotype 2 (HRV2). J Mol Biol. 2000 Jul 28;300(5):1179-94. | ||||
| REF 2 | Minor group human rhinovirus-receptor interactions: geometry of multimodular attachment and basis of recognition. FEBS Lett. 2009 Jan 5;583(1):235-40. | ||||
| REF 3 | X-ray structure of a minor group human rhinovirus bound to a fragment of its cellular receptor protein. Nat Struct Mol Biol. 2004 May;11(5):429-34. | ||||
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