Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T40694 | Target Info | |||
| Target Name | Polo-like kinase 1 (PLK1) | ||||
| Synonyms | Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase 13; Serine-threonine protein kinase 13; STPK13; Plk1; PLK-1; PLK; Mitoticserine-threonine kinase polo-like kinase 1 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PLK1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | 2-(2-Methoxyethoxy)ethanol | Ligand Info | |||
| Canonical SMILES | COCCOCCO | ||||
| InChI | 1S/C5H12O3/c1-7-4-5-8-3-2-6/h6H,2-5H2,1H3 | ||||
| InChIKey | SBASXUCJHJRPEV-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 8134 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 3Q1I Polo-like kinase I Polo-box domain in complex with FMPPPMSpSM phosphopeptide from TCERG1 | ||||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | Yes | [1] |
| PDB Sequence |
CHLSDMLQQL
381 HSVNASKPSE391 RGLVRQEEAE401 DPACIPIFWV411 SKWVDYSDKY421 GLGYQLCDNS 431 VGVLFNDSTR441 LILYNDGDSL451 QYIERDGTES461 YLTVSSHPNS471 LMKKITLLKY 481 FRNYMSEHLL491 KAGANITPRL508 PYLRTWFRTR518 SAIILHLSNG528 SVQINFFQDH 538 TKLILCPLMA548 AVTYIDEKRD558 FRTYRLSLLE568 EYGCCKELAS578 RLRYARTMVD 588 KLLSSR
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| PDB ID: 4E9C The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with LDPPLHSpTA phosphopeptide | ||||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [2] |
| PDB Sequence |
CHLSDMLQQL
381 HSVNASKPSE391 RGLVRQEEAE401 DPACIPIFWV411 SKWVDYSDKY421 GLGYQLCDNS 431 VGVLFNDSTR441 LILYNDGDSL451 QYIERDGTES461 YLTVSSHPNS471 LMKKITLLKY 481 FRNYMSEHLL491 KAGANITPRE501 GDELARLPYL511 RTWFRTRSAI521 ILHLSNGSVQ 531 INFFQDHTKL541 ILCPLMAAVT551 YIDEKRDFRT561 YRLSLLEEYG571 CCKELASRLR 581 YARTMVDKLL591 SSR
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1. Angew Chem Int Ed Engl. 2011 Apr 18;50(17):4003-6. | ||||
| REF 2 | High-throughput interrogation of ligand binding mode using a fluorescence-based assay. Angew Chem Int Ed Engl. 2012 Jul 27;51(31):7680-3. | ||||
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