Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T36075 | Target Info | |||
| Target Name | Glucagon-like peptide 1 receptor (GLP1R) | ||||
| Synonyms | GLP-1R; GLP-1-R; GLP-1 receptor | ||||
| Target Type | Successful Target | ||||
| Gene Name | GLP1R | ||||
| Biochemical Class | GPCR secretin | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | 3-Sulfinoalanine | Ligand Info | |||
| Canonical SMILES | C(C(C(=O)O)N)S(=O)O | ||||
| InChI | 1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/t2-/m0/s1 | ||||
| InChIKey | ADVPTQAUNPRNPO-REOHCLBHSA-N | ||||
| PubChem Compound ID | 1549098 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 5VEW Structure of the human GLP-1 receptor complex with PF-06372222 | ||||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | Yes | [1] |
| PDB Sequence |
SPEEQLLFLY
145 IIYTVGYALS155 FSALVIASAI165 LLGFRHLHCT175 RNYIHLNLFA185 SFILRALCVF 195 FKDAALKWLS219 YQDSLACRLV229 FLLQYCVAAN240 YYWLLVEGVY250 LYTLLAFNIF 1004 EMLRIDEGLR1014 LKIYKDTEGY1024 YTIGIGHLLT1034 KSPSLNAAKS1044 ELDKAIGRNT 1054 NGVITKDEAE1064 KLFNQDVDAA1074 VRGILRNAKL1084 KPVYDSLDAV1094 RRAALINMVF 1104 QMGETGVAGF1114 TNSLRMLQQK1124 RWDEAAVNLA1134 KSRWYNQTPN1144 RAKRVITTFR 1154 TGTWDAYSEQ263 WIFRLYVAIG273 WGVPLLFVVP283 WGIVKYLYED293 EGCWTRNSNM 303 NYWLIIRLPI313 LFACIVNFLI323 FVRVICIVVS333 KLKANLMCKT343 DIAFRLAKST 353 LTLIPLLCTH363 EVIFAFVMDR380 FIKLFTELSF390 TSFQGLMVAI400 LYCFVNNEVQ 410 LEFRKSWERW420 RL
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| PDB ID: 5VEX Structure of the human GLP-1 receptor complex with NNC0640 | ||||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | Yes | [1] |
| PDB Sequence |
SPEEQLLFLY
145 IIYTVGYALS155 FSALVIASAI165 LLGFRHLHCT175 RNYIHLNLFA185 SFILRALCVF 195 FKDAALKWLS219 YQDSLACRLV229 FLLQYCVAAN240 YYWLLVEGVY250 LYTLLAFNIF 1004 EMLRIDEGLR1014 LKIYKDTEGY1024 YTIGIGHLLT1034 KSPSLNAAKS1044 ELDKAIGRNT 1054 NGVITKDEAE1064 KLFNQDVDAA1074 VRGILRNAKL1084 KPVYDSLDAV1094 RRAALINMVF 1104 QMGETGVAGF1114 TNSLRMLQQK1124 RWDEAAVNLA1134 KSRWYNQTPN1144 RAKRVITTFR 1154 TGTWDAYSEQ263 WIFRLYVAIG273 WGVPLLFVVP283 WGIVKYLYED293 EGCWTRNSNM 303 NYWLIIRLPI313 LFACIVNFLI323 FVRVICIVVS333 KLKANLMCKT343 DIAFRLAKST 353 LTLIPLLCTH363 EVIFAFVMDR380 FIKLFTELSF390 TSFQGLMVAI400 LYCFVNNEVQ 410 LEFRKSWERW420 RL
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature. 2017 Jun 8;546(7657):312-315. | ||||
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