Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T31721 | Target Info | |||
| Target Name | Excitatory amino acid transporter 3 (SLC1A1) | ||||
| Synonyms | Solute carrier family 1 member 1; Sodium-dependent glutamate/aspartate transporter 3; Neuronal and epithelial glutamate transporter; Excitatory amino-acid carrier 1; EAAT3; EAAC1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SLC1A1 | ||||
| Biochemical Class | Dicarboxylate/amino acid:cation symporter | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Cholesterol hemisuccinate | Ligand Info | |||
| Canonical SMILES | CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)CCC(=O)O)C)C | ||||
| InChI | 1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1 | ||||
| InChIKey | WLNARFZDISHUGS-MIXBDBMTSA-N | ||||
| PubChem Compound ID | 65082 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6S3Q Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with TFB-TBOA | ||||||
| Method | Electron microscopy | Resolution | 3.34 Å | Mutation | Yes | [1] |
| PDB Sequence |
EWKRFLKNNW
19 VLLSTVAAVV29 LGITTGVLVR39 EHRNLSTLEK49 FYFAFPGEIL59 MRMLKLIILP 69 LIISSMITGV79 AALDSNVSGK89 IGVRAVVYYF99 CTTLIAVILG109 IVLVVSIKPG 119 VTQVSTVDAM142 LDLIRNMFPE152 NLVQACFQQY162 KTKREEVKPK196 TKEYKIVGMY 206 SDGINVLGLI216 VFCLVFGLVI226 GKMGEKGQIL236 VDFFNALSDA246 TMKIVQIIMC 256 YMPLGILFLI266 AGKIIEVEDW276 EIFRKLGLYM286 ATVLTGLAIH296 SIVILPLIYF 306 IVVRKNPFRF316 AMGMAQALLT326 ALMISSSSAT336 LPVTFRCAEE346 NNQVDKRITR 356 FVLPVGATIN366 MDGTALYEAV376 AAVFIAQLND386 LDLGIGQIIT396 ISITATSASI 406 GAAGVPQAGL416 VTMVIVLSAV426 GLPAEDVTLI436 IAVDWLLDRF446 RTMVNVLGDA 456 FGTGIVEKLS466 KKELEQMDVS476
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| PDB ID: 7NSG Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with HIP-B | ||||||
| Method | Electron microscopy | Resolution | 3.34 Å | Mutation | Yes | [2] |
| PDB Sequence |
EWKRFLKNNW
19 VLLSTVAAVV29 LGITTGVLVR39 EHRNLSTLEK49 FYFAFPGEIL59 MRMLKLIILP 69 LIISSMITGV79 AALDSNVSGK89 IGVRAVVYYF99 CTTLIAVILG109 IVLVVSIKPG 119 VTQVSTVDAM142 LDLIRNMFPE152 NLVQACFQQY162 KTKREEVKPK196 TKEYKIVGMY 206 SDGINVLGLI216 VFCLVFGLVI226 GKMGEKGQIL236 VDFFNALSDA246 TMKIVQIIMC 256 YMPLGILFLI266 AGKIIEVEDW276 EIFRKLGLYM286 ATVLTGLAIH296 SIVILPLIYF 306 IVVRKNPFRF316 AMGMAQALLT326 ALMISSSSAT336 LPVTFRCAEE346 NNQVDKRITR 356 FVLPVGATIN366 MDGTALYEAV376 AAVFIAQLND386 LDLGIGQIIT396 ISITATSASI 406 GAAGVPQAGL416 VTMVIVLSAV426 GLPAEDVTLI436 IAVDWLLDRF446 RTMVNVLGDA 456 FGTGIVEKLS466 KKELEQMDVS476
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of human excitatory amino acid transporter 3 (EAAT3) | ||||
| REF 2 | Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with HIP-B | ||||
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