Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T31543 | Target Info | |||
| Target Name | Suppressor of tumorigenicity 14 protein (ST14) | ||||
| Synonyms | Tumor-associated differentially-expressed gene 15 protein; Tumor associated differentially-expressed gene-15 protein; TADG15; Serine protease TADG-15; Serine protease 14; SNC19; Prostamin; PRSS14; Membrane-type serine protease 1; Membrane type serine protease 1; Matriptase; MT-SP1 | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | ST14 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Benzamidine | Ligand Info | |||
| Canonical SMILES | C1=CC=C(C=C1)C(=N)N | ||||
| InChI | 1S/C7H8N2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H3,8,9) | ||||
| InChIKey | PXXJHWLDUBFPOL-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 2332 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 3P8G Crystal Structure of MT-SP1 in complex with benzamidine | ||||||
| Method | X-ray diffraction | Resolution | 1.20 Å | Mutation | Yes | [1] |
| PDB Sequence |
VVGGTDADEG
25 EWPWQVSLHA35 LGQGHICGAS45 LISPNWLVSA55 AHCYIDDRGF60E RYSDPTQWTA 66 FLGLHDQSQR76 SAPGVQERRL85 KRIISHPFFN95 DFTFDYDIAL105 LELEKPAEYS 115 SMVRPICLPD125 ASHVFPAGKA135 IWVTGWGHTQ145 YGGTGALILQ156 KGEIRVIQQT 166 TCENLLPQQI176 TPRMMCVGFL185 SGGVDSCQGD194 SGGPLSSVEA204 DGRIFQAGVV 213 SWGDGCAQRN223 KPGVYTRLPL233 FRDWIKENTG243 V
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| PDB ID: 1EAX Crystal structure of MTSP1 (matriptase) | ||||||
| Method | X-ray diffraction | Resolution | 1.30 Å | Mutation | No | [2] |
| PDB Sequence |
VVGGTDADEG
25 EWPWQVSLHA35 LGQGHICGAS45 LISPNWLVSA55 AHCYIDDRGF60E RYSDPTQWTA 66 FLGLHDQSQR76 SAPGVQERRL85 KRIISHPFFN95 DFTFDYDIAL105 LELEKPAEYS 115 SMVRPICLPD125 ASHVFPAGKA135 IWVTGWGHTQ145 YGGTGALILQ156 KGEIRVINQT 166 TCENLLPQQI176 TPRMMCVGFL185 SGGVDSCQGD194 SGGPLSSVEA204 DGRIFQAGVV 213 SWGDGCAQRN223 KPGVYTRLPL233 FRDWIKENTG243 V
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1. BMC Struct Biol. 2011 Jun 22;11:30. | ||||
| REF 2 | Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase. J Biol Chem. 2002 Jan 18;277(3):2160-8. | ||||
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