Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T30784 | Target Info | |||
| Target Name | Thrombospondin-1 (THBS1) | ||||
| Synonyms | TSP1; TSP; Glycoprotein G | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | THBS1 | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | alpha-L-Fucose | Ligand Info | |||
| Canonical SMILES | CC1C(C(C(C(O1)O)O)O)O | ||||
| InChI | 1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3+,4+,5-,6+/m0/s1 | ||||
| InChIKey | SHZGCJCMOBCMKK-SXUWKVJYSA-N | ||||
| PubChem Compound ID | 439554 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7YYK Crystal structure of the O-fucosylated form of TSRs1-3 from the human thrombospondin 1 | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [1] |
| PDB Sequence |
QDGGWSHWSP
443 WSSCSVTCGD453 GVITRIRLCN463 SPSPQMNGKP473 CEGEARETKA483 CKKDACPING 493 GWGPWSPWDI503 CSVTCGGGVQ513 KRSRLCNNPT523 PQFGGKDCVG533 DVTENQICNK 543 QDCP
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| PDB ID: 1LSL Crystal Structure of the Thrombospondin-1 Type 1 Repeats | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [2] |
| PDB Sequence |
QDGGWSHWSP
425 WSSCSVTCGD435 GVITRIRLCN445 SPSPQMNGKP455 CEGEARETKA465 CKKDACPING 475 GWGPWSPWDI485 CSVTCGGGVQ495 KRSRLCNNPT505 PQFGGKDCVG515 DVTENQICNK 525 QDC
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | O-fucosylation stabilizes the TSR3 motif in thrombospondin-1 by interacting with nearby amino acids and protecting a disulfide bond. J Biol Chem. 2022 Jun;298(6):102047. | ||||
| REF 2 | Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication. J Cell Biol. 2002 Oct 28;159(2):373-82. | ||||
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