Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T28309 | Target Info | |||
| Target Name | Mucolipin-1 (TRPML1) | ||||
| Synonyms | Transient receptor potential channel mucolipin 1; TRPML1; Mucolipidin; MSTP080; ML4; ML1; MG-2 | ||||
| Target Type | Preclinical Target | ||||
| Gene Name | MCOLN1 | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | (1R,2S,3S,4R,5S,6R)-5-{[(R)-[(2R)-2,3-bis{[(1S)-1-hydroxyoctyl]oxy}propoxy](hydroxy)phosphoryl]oxy}-2,4,6-trihydroxycyclohexane-1,3-diyl bis[dihydrogen (phosphate)] | Ligand Info | |||
| PubChem Substance ID | 376250352 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6E7P cryo-EM structure of human TRPML1 with PI35P2 | ||||||
| Method | Electron microscopy | Resolution | 3.50 Å | Mutation | No | [1] |
| PDB Sequence |
EEDLRRRLKY
47 FFMSPCDKFR57 AKGRKPCKLM67 LQVVKILVVT77 VQLILFGLSN87 QLAVTFREEN 97 TIAFRHLFLL107 GYSDGADDTF117 AAYTREQLYQ127 AIFHAVDQYL137 ALPDVSLGRY 147 AYVRGGGDPW157 TNGSGLALCQ167 RYYHRGHVDP177 ANDTFDIDPM187 VVTDCIQVDP 197 PERPSSYKNL221 TLKFHKLVNV231 TIHFRLKTIN241 LQSLINNEIP251 DCYTFSVLIT 261 FDNKAHSGRI271 PISLETQAHI281 QECKHPSVFQ291 HGDNSFRLLF301 DVVVILTCSL 311 SFLLCARSLL321 RGFLLQNEFV331 GFMWRQRGRV341 ISLWERLEFV351 NGWYILLVTS 361 DVLTISGTIM371 KIGIEAKNLA381 SYDVCSILLG391 TSTLLVWVGV401 IRYLTFFHNY 411 NILIATLRVA421 LPSVMRFCCC431 VAVIYLGYCF441 CGWIVLGPYH451 VKFRSLSMVS 461 ECLFSLINGD471 DMFVTFAAMQ481 AQQGRSSLVW491 LFSQLYLYSF501 ISLFIYMVLS 511 LFIALITGAY521 DTIKH
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| PDB ID: 6E7Z cryo-EM structure of human TRPML1 with ML-SA1 and PI35P2 | ||||||
| Method | Electron microscopy | Resolution | 3.73 Å | Mutation | No | [1] |
| PDB Sequence |
EEDLRRRLKY
47 FFMSPCDKFR57 AKGRKPCKLM67 LQVVKILVVT77 VQLILFGLSN87 QLAVTFREEN 97 TIAFRHLFLL107 GYSDGADDTF117 AAYTREQLYQ127 AIFHAVDQYL137 ALPDVSLGRY 147 AYVRGGGDPW157 TNGSGLALCQ167 RYYHRGHVDP177 ANDTFDIDPM187 VVTDCIQVDP 197 PERPSSYKNL221 TLKFHKLVNV231 TIHFRLKTIN241 LQSLINNEIP251 DCYTFSVLIT 261 FDNKAHSGRI271 PISLETQAHI281 QECKHPSVFQ291 HGDNSFRLLF301 DVVVILTCSL 311 SFLLCARSLL321 RGFLLQNEFV331 GFMWRQRGRV341 ISLWERLEFV351 NGWYILLVTS 361 DVLTISGTIM371 KIGIEAKNLA381 SYDVCSILLG391 TSTLLVWVGV401 IRYLTFFHNY 411 NILIATLRVA421 LPSVMRFCCC431 VAVIYLGYCF441 CGWIVLGPYH451 VKFRSLSMVS 461 ECLFSLINGD471 DMFVTFAAMQ481 AQQGRSSLVW491 LFSQLYLYSF501 ISLFIYMVLS 511 LFIALITGAY521 DTIKH
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis for PtdInsP(2)-mediated human TRPML1 regulation. Nat Commun. 2018 Oct 10;9(1):4192. | ||||
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