Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T28226 | Target Info | |||
| Target Name | GTP cyclohydrolase-I (GCH1) | ||||
| Synonyms | Guanosine triphosphate cyclohydrolase I; GTP-CH-I; GTP cyclohydrolase I; GTP cyclohydrolase 1; GCH; DYT5 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | GCH1 | ||||
| Biochemical Class | Carbon-nitrogen hydrolase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | 5-Imino-[1,3]thiazolo[5,4-d]pyrimidine-2,7-dione | Ligand Info | |||
| Canonical SMILES | C12=NC(=O)SC1=NC(=N)NC2=O | ||||
| InChI | 1S/C5H2N4O2S/c6-4-8-2(10)1-3(9-4)12-5(11)7-1/h(H2,6,8,10) | ||||
| InChIKey | AXABAVYDNQCEBU-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 155804488 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6Z89 human GTP cyclohydrolase I in complex with allosteric inhibitor | ||||||
| Method | X-ray diffraction | Resolution | 2.37 Å | Mutation | No | [1] |
| PDB Sequence |
PRSEEDNELN
67 LPNLAAAYSS77 ILSSLGENPQ87 RQGLLKTPWR97 AASAMQFFTK107 GYQETISDVL 117 NDAIFDEDHD127 EMVIVKDIDM137 FSMCEHHLVP147 FVGKVHIGYL157 PNKQVLGLSK 167 LARIVEIYSR177 RLQVQERLTK187 QIAVAITEAL197 RPAGVGVVVE207 ATHMNSKTVT 227 STMLGVFRED237 PKTREEFLTL247 I
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| PDB ID: 6Z88 human GTP cyclohydrolase I in complex with allosteric inhibitor | ||||||
| Method | X-ray diffraction | Resolution | 2.69 Å | Mutation | No | [1] |
| PDB Sequence |
PRSEEDNELN
67 LPNLAAAYSS77 ILSSLGENPQ87 RQGLLKTPWR97 AASAMQFFTK107 GYQETISDDH 126 DEMVIVKDID136 MFSMCEHHLV146 PFVGKVHIGY156 LPNKQVLGLS166 KLARIVEIYS 176 RRLQVQERLT186 KQIAVAITEA196 LRPAGVGVVV206 EATHMCMVSK224 TVTSTMLGVF 234 REDPKTREEF244 LTLIR
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):31838-31849. | ||||
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