Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T27376 | Target Info | |||
| Target Name | GABA(A) receptor delta (GABRD) | ||||
| Synonyms | Gammaaminobutyric acid receptor subunit delta; GABRD; GABA(A) receptor subunit delta | ||||
| Target Type | Successful Target | ||||
| Gene Name | GABRD | ||||
| Biochemical Class | Ligand-gated ion channel | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Decane | Ligand Info | |||
| Canonical SMILES | CCCCCCCCCC | ||||
| InChI | 1S/C10H22/c1-3-5-7-9-10-8-6-4-2/h3-10H2,1-2H3 | ||||
| InChIKey | DIOQZVSQGTUSAI-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 15600 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7QN5 Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with nanobody Nb25 | ||||||
| Method | Electron microscopy | Resolution | 2.50 Å | Mutation | No | [1] |
| PDB Sequence |
PNLDGLIAGY
51 ARNFRPGIGG61 PPVNVALALE71 VASIDHISEA81 NMEYTMTVFL91 HQSWRDSRLS 101 YNHTNETLGL111 DSRFVDKLWL121 PDTFIVNAKS131 AWFHDVTVEN141 KLIRLQPDGV 151 ILYSIRITST161 VACDMDLAKY171 PMDEQECMLD181 LESYGYSSED191 IVYYWSESQE 201 HIHGLDKLQL211 AQFTITSYRF221 TTELMNFKSA231 GQFPRLSLHF241 HLRRNRGVYI 251 IQSYMPSVLL261 VAMSWVSFWI271 SQAAVPARVS281 LGITTVLTMT291 TLMVSARSSL 301 PRASAIKALD311 VYFWICYVFV321 FAALVEYAFA331 HFNADADTID428 IYARAVFPAA 438 FAAVNVIYWA448 AYA
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| PDB ID: 7QN7 Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with GABA, histamine and nanobody Nb25 | ||||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | No | [1] |
| PDB Sequence |
PNLDGLIAGY
51 ARNFRPGIGG61 PPVNVALALE71 VASIDHISEA81 NMEYTMTVFL91 HQSWRDSRLS 101 YNHTNETLGL111 DSRFVDKLWL121 PDTFIVNAKS131 AWFHDVTVEN141 KLIRLQPDGV 151 ILYSIRITST161 VACDMDLAKY171 PMDEQECMLD181 LESYGYSSED191 IVYYWSESQE 201 HIHGLDKLQL211 AQFTITSYRF221 TTELMNFKSA231 GQFPRLSLHF241 HLRRNRGVYI 251 IQSYMPSVLL261 VAMSWVSFWI271 SQAAVPARVS281 LGITTVLTMT291 TLMVSARSSL 301 PRASAIKALD311 VYFWICYVFV321 FAALVEYAFA331 HFNADADTID428 IYARAVFPAA 438 FAAVNVIYWA448 AYA
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Differential assembly diversifies GABA(A) receptor structures and signalling. Nature. 2022 Apr;604(7904):190-194. | ||||
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