Target Binding Site Detail

Content Navigation (  All   None )                                      
Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T24089 Target Info
Target Name Cholecystokinin (CCK)
Synonyms Procholecystokinin; CCK
Target Type Literature-reported Target
Gene Name CCK
Biochemical Class Gastrin cholecystokinin
UniProt ID
CCKN_HUMAN
Ligand General Information  Top
Ligand Name tyrosine O-sulfate Ligand Info
Canonical SMILES C1=CC(=CC=C1CC(C(=O)O)N)OS(=O)(=O)O
InChI 1S/C9H11NO6S/c10-8(9(11)12)5-6-1-3-7(4-2-6)16-17(13,14)15/h1-4,8H,5,10H2,(H,11,12)(H,13,14,15)/t8-/m0/s1
InChIKey CIQHWLTYGMYQQR-QMMMGPOBSA-N
PubChem Compound ID 514186
Drug Binding Sites of Target  Top
PDB ID: 7MBX      Human Cholecystokinin 1 receptor (CCK1R) Gs complex
Method Electron microscopy Resolution 1.95 Å Mutation Yes [1]
PDB Sequence
DMGWMDF
Residue
Distance (Å)
ASP1
1.329
MET3
1.328
GLY4
3.808
Residue
Distance (Å)
TRP5
3.972
MET6
3.353
PDB ID: 7MBY      Human Cholecystokinin 1 receptor (CCK1R) Gq chimera (mGsqi) complex
Method Electron microscopy Resolution 2.44 Å Mutation Yes [1]
PDB Sequence
DMGWMDF
Residue
Distance (Å)
ASP1
1.329
MET3
1.329
GLY4
4.101
Residue
Distance (Å)
TRP5
4.717
MET6
3.480
References  Top
REF 1 Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. PLoS Biol. 2021 Jun 4;19(6):e3001295.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.