Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T18904 | Target Info | |||
| Target Name | Lysine-specific demethylase 4A (KDM4A) | ||||
| Synonyms | KIAA0677; Jumonji domain-containing protein 2A; JmjC domain-containing histone demethylation protein 3A; JMJD2A; JMJD2; JHDM3A | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | KDM4A | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | 2-(carboxymethylamino)-2-oxoacetic acid | Ligand Info | |||
| Canonical SMILES | C(C(=O)O)NC(=O)C(=O)O | ||||
| InChI | 1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10) | ||||
| InChIKey | BIMZLRFONYSTPT-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 3080614 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 4V2W JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27me3 PEPTIDE (16-35) | ||||||
| Method | X-ray diffraction | Resolution | 1.81 Å | Mutation | No | [1] |
| PDB Sequence |
TLNPSARIMT
16 FYPTMEEFRN26 FSRYIAYIES36 QGAHRAGLAK46 VVPPKEWKPR56 ASYDDIDDLV 66 IPAPIQQLVT76 GQSGLFTQYN86 IQKKAMTVRE96 FRKIANSDKY106 CTPRYSEFEE 116 LERKYWKNLT126 FNPPIYGADV136 NGTLYEKHVD146 EWNIGRLRTI156 LDLVEKESGI 166 TIEGVNTPYL176 YFGMWKTSFA186 WHTEDMDLYS196 INYLHFGEPK206 SWYSVPPEHG 216 KRLERLAKGF226 FPGSAQSCEA236 FLRHKMTLIS246 PLMLKKYGIP256 FDKVTQEAGE 266 FMITFPYGYH276 AGFNHGFNCA286 ESTNFATRRW296 IEYGKQAVLC306 SCRKDMVKIS 316 MDVFVRKFQP326 ERYKLWKAGK336 DNTVIDHTLP346 TPEAAEFL
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| PDB ID: 2OX0 Crystal structure of JMJD2A complexed with histone H3 peptide dimethylated at Lys9 | ||||||
| Method | X-ray diffraction | Resolution | 1.95 Å | Mutation | No | [2] |
| PDB Sequence |
TLNPSARIMT
16 FYPTMEEFRN26 FSRYIAYIES36 QGAHRAGLAK46 VVPPKEWKPR56 ASYDDIDDLV 66 IPAPIQQLVT76 GQSGLFTQYN86 IQKKAMTVRE96 FRKIANSDKY106 CTPRYSEFEE 116 LERKYWKNLT126 FNPPIYGADV136 NGTLYEKHVD146 EWNIGRLRTI156 LDLVEKESGI 166 TIEGVNTPYL176 YFGMWKTSFA186 WHTEDMDLYS196 INYLHFGEPK206 SWYSVPPEHG 216 KRLERLAKGF226 FPGSAQSCEA236 FLRHKMTLIS246 PLMLKKYGIP256 FDKVTQEAGE 266 FMITFPYGYH276 AGFNHGFNCA286 ESTNFATRRW296 IEYGKQAVLC306 SCRKDMVKIS 316 MDVFVRKFQP326 ERYKLWKAGK336 DNTVIDHTLP346 TPEAAEFLK
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| PDB ID: 6H8P JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND Histone H1.4(18-32)K26me3 peptide (15-mer) | ||||||
| Method | X-ray diffraction | Resolution | 1.98 Å | Mutation | No | [3] |
| PDB Sequence |
NPSARIMTFY
18 PTMEEFRNFS28 RYIAYIESQG38 AHRAGLAKVV48 PPKEWKPRAS58 YDDIDDLVIP 68 APIQQLVTGQ78 SGLFTQYNIQ88 KKAMTVREFR98 KIANSDKYCT108 PRYSEFEELE 118 RKYWKNLTFN128 PPIYGADVNG138 TLYEKHVDEW148 NIGRLRTILD158 LVEKESGITI 168 EGVNTPYLYF178 GMWKTSFAWH188 TEDMDLYSIN198 YLHFGEPKSW208 YSVPPEHGKR 218 LERLAKGFFP228 GSAQSCEAFL238 RHKMTLISPL248 MLKKYGIPFD258 KVTQEAGEFM 268 ITFPYGYHAG278 FNHGFNCAES288 TNFATRRWIE298 YGKQAVLCSC308 RKDMVKISMD 318 VFVRKFQPER328 YKLWKAGKDN338 TVIDHTLPTP348 EAAEFL
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| PDB ID: 2OQ6 Crystal structure of JMJD2A complexed with histone H3 peptide trimethylated at Lys9 | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [2] |
| PDB Sequence |
LNPSARIMTF
17 YPTMEEFRNF27 SRYIAYIESQ37 GAHRAGLAKV47 VPPKEWKPRA57 SYDDIDDLVI 67 PAPIQQLVTG77 QSGLFTQYNI87 QKKAMTVREF97 RKIANSDKYC107 TPRYSEFEEL 117 ERKYWKNLTF127 NPPIYGADVN137 GTLYEKHVDE147 WNIGRLRTIL157 DLVEKESGIT 167 IEGVNTPYLY177 FGMWKTSFAW187 HTEDMDLYSI197 NYLHFGEPKS207 WYSVPPEHGK 217 RLERLAKGFF227 PGSAQSCEAF237 LRHKMTLISP247 LMLKKYGIPF257 DKVTQEAGEF 267 MITFPYGYHA277 GFNHGFNCAE287 STNFATRRWI297 EYGKQAVLCS307 CRKDMVKISM 317 DVFVRKFQPE327 RYKLWKAGKD337 NTVIDHTLPT347 PEAAEFLK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OGA or .OGA2 or .OGA3 or :3OGA;style chemicals stick;color identity;select .A:132 or .A:177 or .A:185 or .A:188 or .A:190 or .A:196 or .A:197 or .A:198 or .A:206 or .A:208 or .A:270 or .A:276 or .A:286 or .A:288; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 4V2V JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27me3 PEPTIDE (25-29) ARK(me3)SA | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [1] |
| PDB Sequence |
SESETLNPSA
12 RIMTFYPTME22 EFRNFSRYIA32 YIESQGAHRA42 GLAKVVPPKE52 WKPRASYDDI 62 DDLVIPAPIQ72 QLVTGQSGLF82 TQYNIQKKAM92 TVREFRKIAN102 SDKYCTPRYS 112 EFEELERKYW122 KNLTFNPPIY132 GADVNGTLYE142 KHVDEWNIGR152 LRTILDLVEK 162 ESGITIEGVN172 TPYLYFGMWK182 TSFAWHTEDM192 DLYSINYLHF202 GEPKSWYSVP 212 PEHGKRLERL222 AKGFFPGSAQ232 SCEAFLRHKM242 TLISPLMLKK252 YGIPFDKVTQ 262 EAGEFMITFP272 YGYHAGFNHG282 FNCAESTNFA292 TRRWIEYGKQ302 AVLCSCRKDM 312 VKISMDVFVR322 KFQPERYKLW332 KAGKDNTVID342 HTLPTPEAAE352 FLK |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OGA or .OGA2 or .OGA3 or :3OGA;style chemicals stick;color identity;select .A:132 or .A:177 or .A:185 or .A:188 or .A:190 or .A:196 or .A:197 or .A:198 or .A:206 or .A:208 or .A:270 or .A:276 or .A:286 or .A:288; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5FWE JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H4(1-15)R3me2s PEPTIDE | ||||||
| Method | X-ray diffraction | Resolution | 2.05 Å | Mutation | No | [4] |
| PDB Sequence |
TLNPSARIMT
16 FYPTMEEFRN26 FSRYIAYIES36 QGAHRAGLAK46 VVPPKEWKPR56 ASYDDIDDLV 66 IPAPIQQLVT76 GQSGLFTQYN86 IQKKAMTVRE96 FRKIANSDKY106 CTPRYSEFEE 116 LERKYWKNLT126 FNPPIYGADV136 NGTLYEKHVD146 EWNIGRLRTI156 LDLVEKESGI 166 TIEGVNTPYL176 YFGMWKTSFA186 WHTEDMDLYS196 INYLHFGEPK206 SWYSVPPEHG 216 KRLERLAKGF226 FPGSAQSCEA236 FLRHKMTLIS246 PLMLKKYGIP256 FDKVTQEAGE 266 FMITFPYGYH276 AGFNHGFNCA286 ESTNFATRRW296 IEYGKQAVLC306 SCRKDMVKIS 316 MDVFVRKFQP326 ERYKLWKAGK336 DNTVIDHTLP346 TPEAAEFL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OGA or .OGA2 or .OGA3 or :3OGA;style chemicals stick;color identity;select .A:132 or .A:177 or .A:185 or .A:188 or .A:190 or .A:196 or .A:197 or .A:198 or .A:206 or .A:208 or .A:270 or .A:276 or .A:280 or .A:286 or .A:288; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2OT7 Crystal structure of JMJD2A complexed with histone H3 peptide monomethylated at Lys9 | ||||||
| Method | X-ray diffraction | Resolution | 2.13 Å | Mutation | No | [2] |
| PDB Sequence |
TLNPSARIMT
16 FYPTMEEFRN26 FSRYIAYIES36 QGAHRAGLAK46 VVPPKEWKPR56 ASYDDIDDLV 66 IPAPIQQLVT76 GQSGLFTQYN86 IQKKAMTVRE96 FRKIANSDKY106 CTPRYSEFEE 116 LERKYWKNLT126 FNPPIYGADV136 NGTLYEKHVD146 EWNIGRLRTI156 LDLVEKESGI 166 TIEGVNTPYL176 YFGMWKTSFA186 WHTEDMDLYS196 INYLHFGEPK206 SWYSVPPEHG 216 KRLERLAKGF226 FPGSAQSCEA236 FLRHKMTLIS246 PLMLKKYGIP256 FDKVTQEAGE 266 FMITFPYGYH276 AGFNHGFNCA286 ESTNFATRRW296 IEYGKQAVLC306 SCRKDMVKIS 316 MDVFVRKFQP326 ERYKLWKAGK336 DNTVIDHTLP346 TPEAAEFLK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OGA or .OGA2 or .OGA3 or :3OGA;style chemicals stick;color identity;select .A:132 or .A:177 or .A:185 or .A:188 or .A:190 or .A:196 or .A:197 or .A:198 or .A:206 or .A:208 or .A:270 or .A:276 or .A:288; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2OQ7 The crystal structure of JMJD2A complexed with Ni and N-oxalylglycine | ||||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | No | [2] |
| PDB Sequence |
LNPSARIMTF
17 YPTMEEFRNF27 SRYIAYIESQ37 GAHRAGLAKV47 VPPKEWKPRA57 SYDDIDDLVI 67 PAPIQQLVTG77 QSGLFTQYNI87 QKKAMTVREF97 RKIANSDKYC107 TPRYSEFEEL 117 ERKYWKNLTF127 NPPIYGADVN137 GTLYEKHVDE147 WNIGRLRTIL157 DLVEKESGIT 167 IEGVNTPYLY177 FGMWKTSFAW187 HTEDMDLYSI197 NYLHFGEPKS207 WYSVPPEHGK 217 RLERLAKGFF227 PGSAQSCEAF237 LRHKMTLISP247 LMLKKYGIPF257 DKVTQEAGEF 267 MITFPYGYHA277 GFNHGFNCAE287 STNFATRRWI297 EYGKQAVLCS307 CRKDMVKISM 317 DVFVRKFQPE327 RYKLWKAGKD337 NTVIDHTLPT347 PEAAEFL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OGA or .OGA2 or .OGA3 or :3OGA;style chemicals stick;color identity;select .A:132 or .A:177 or .A:185 or .A:188 or .A:190 or .A:196 or .A:197 or .A:198 or .A:206 or .A:208 or .A:270 or .A:276 or .A:286 or .A:288; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2OS2 Crystal structure of JMJD2A complexed with histone H3 peptide trimethylated at Lys36 | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [2] |
| PDB Sequence |
LNPSARIMTF
17 YPTMEEFRNF27 SRYIAYIESQ37 GAHRAGLAKV47 VPPKEWKPRA57 SYDDIDDLVI 67 PAPIQQLVTG77 QSGLFTQYNI87 QKKAMTVREF97 RKIANSDKYC107 TPRYSEFEEL 117 ERKYWKNLTF127 NPPIYGADVN137 GTLYEKHVDE147 WNIGRLRTIL157 DLVEKESGIT 167 IEGVNTPYLY177 FGMWKTSFAW187 HTEDMDLYSI197 NYLHFGEPKS207 WYSVPPEHGK 217 RLERLAKGFF227 PGSAQSCEAF237 LRHKMTLISP247 LMLKKYGIPF257 DKVTQEAGEF 267 MITFPYGYHA277 GFNHGFNCAE287 STNFATRRWI297 EYGKQAVLCS307 CRKDMVKISM 317 DVFVRKFQPE327 RYKLWKAGKD337 NTVIDHTLPT347 PEAAEFL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OGA or .OGA2 or .OGA3 or :3OGA;style chemicals stick;color identity;select .A:132 or .A:177 or .A:185 or .A:188 or .A:190 or .A:196 or .A:197 or .A:198 or .A:206 or .A:208 or .A:270 or .A:276 or .A:286 or .A:288; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5LY2 JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND Macrocyclic PEPTIDE Inhibitor CP2_R6Kme3 (13-mer) | ||||||
| Method | X-ray diffraction | Resolution | 2.43 Å | Mutation | No | [5] |
| PDB Sequence |
TLNPSARIMT
16 FYPTMEEFRN26 FSRYIAYIES36 QGAHRAGLAK46 VVPPKEWKPR56 ASYDDIDDLV 66 IPAPIQQLVT76 GQSGLFTQYN86 IQKKAMTVRE96 FRKIANSDKY106 CTPRYSEFEE 116 LERKYWKNLT126 FNPPIYGADV136 NGTLYEKHVD146 EWNIGRLRTI156 LDLVEKESGI 166 TIEGVNTPYL176 YFGMWKTSFA186 WHTEDMDLYS196 INYLHFGEPK206 SWYSVPPEHG 216 KRLERLAKGF226 FPGSAQSCEA236 FLRHKMTLIS246 PLMLKKYGIP256 FDKVTQEAGE 266 FMITFPYGYH276 AGFNHGFNCA286 ESTNFATRRW296 IEYGKQAVLC306 SCRKDMVKIS 316 MDVFVRKFQP326 ERYKLWKAGK336 DNTVIDHTLP346 TPEAAEFL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OGA or .OGA2 or .OGA3 or :3OGA;style chemicals stick;color identity;select .A:132 or .A:177 or .A:185 or .A:188 or .A:190 or .A:196 or .A:197 or .A:198 or .A:206 or .A:208 or .A:270 or .A:276 or .A:288; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 6HGT Crystal structure of human KDM4A complexed with co-substrate analog NOG and histone H3 peptide with K9R mutation | ||||||
| Method | X-ray diffraction | Resolution | 2.33 Å | Mutation | Yes | [6] |
| PDB Sequence |
SETLNPSARI
14 MTFYPTMEEF24 RNFSRYIAYI34 ESQGAHRAGL44 AKVVPPKEWK54 PRASYDDIDD 64 LVIPAPIQQL74 VTGQSGLFTQ84 YNIQKKAMTV94 REFRKIANSD104 KYCTPRYSEF 114 EELERKYWKN124 LTFNPPIYGA134 DVNGTLYEKH144 VDEWNIGRLR154 TILDLVEKES 164 GITIEGVNTP174 YLYFGMWKTS184 FAWHTEDMDL194 YSINYLHFGE204 PKSWYSVPPE 214 HGKRLERLAK224 GFFPGSAQSC234 EAFLRHKMTL244 ISPLMLKKYG254 IPFDKVTQEA 264 GEFMITFPYG274 YHAGFNHGFN284 CAESTNFATR294 RWIEYGKQAV304 LCSCRKDMVK 314 ISMDVFVRKF324 QPERYKLWKA334 GKDNTVIDHT344 LPTPEAAEFL354 |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OGA or .OGA2 or .OGA3 or :3OGA;style chemicals stick;color identity;select .A:132 or .A:177 or .A:185 or .A:188 or .A:190 or .A:196 or .A:197 or .A:198 or .A:206 or .A:208 or .A:270 or .A:276 or .A:286 or .A:288; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2P5B The complex structure of JMJD2A and trimethylated H3K36 peptide | ||||||
| Method | X-ray diffraction | Resolution | 1.99 Å | Mutation | Yes | [7] |
| PDB Sequence |
ASESETLNPS
11 ARIMTFYPTM21 EEFRNFSRYI31 AYIESQGAHR41 AGLAKVVPPK51 EWKPRASYDD 61 IDDLVIPAPI71 QQLVTGQSGL81 FTQYNIQKKA91 MTVREFRKIA101 NSDKYCTPRY 111 SEFEELERKY121 WKNLTFNPPI131 YGADVNGTLY141 EKHVDEWNIG151 RLRTILDLVE 161 KESGITIEGV171 NTPYLYFGMW181 KTSFAWHTED191 MDLYSINYLH201 FGEPKSWYSV 211 PPEHGKRLER221 LAKGFFPGSA231 QSCEAFLRHK241 MTLISPLMLK251 KYGIPFDKVT 261 QEAGEFMITF271 PYGYHAGFNH281 GFNCAESTNF291 ATRRWIEYGK301 QAVLCSCRKD 311 MVKISMDVFV321 RKFQPERYKL331 WKAGKDNTVI341 DHTLPTP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OGA or .OGA2 or .OGA3 or :3OGA;style chemicals stick;color identity;select .A:132 or .A:177 or .A:185 or .A:188 or .A:190 or .A:196 or .A:197 or .A:198 or .A:206 or .A:208 or .A:270 or .A:276 or .A:288; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2Q8E Specificity and Mechanism of JMJD2A, a Trimethyllysine-Specific Histone Demethylase | ||||||
| Method | X-ray diffraction | Resolution | 2.05 Å | Mutation | No | [8] |
| PDB Sequence |
SESETLNPSA
12 RIMTFYPTME22 EFRNFSRYIA32 YIESQGAHRA42 GLAKVVPPKE52 WKPRASYDDI 62 DDLVIPAPIQ72 QLVTGQSGLF82 TQYNIQKKAM92 TVREFRKIAN102 SDKYCTPRYS 112 EFEELERKYW122 KNLTFNPPIY132 GADVNGTLYE142 KHVDEWNIGR152 LRTILDLVEK 162 ESGITIEGVN172 TPYLYFGMWK182 TSFAWHTEDM192 DLYSINYLHF202 GEPKSWYSVP 212 PEHGKRLERL222 AKGFFPGSAQ232 SCEAFLRHKM242 TLISPLMLKK252 YGIPFDKVTQ 262 EAGEFMITFP272 YGYHAGFNHG282 FNCAESTNFA292 TRRWIEYGKQ302 AVLCSCRKDM 312 VKISMDVFVR322 KFQPERYKLW332 KAGKDNTVID342 HTLP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OGA or .OGA2 or .OGA3 or :3OGA;style chemicals stick;color identity;select .A:132 or .A:177 or .A:185 or .A:188 or .A:190 or .A:196 or .A:197 or .A:198 or .A:206 or .A:208 or .A:270 or .A:276 or .A:286 or .A:288; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2PXJ The complex structure of JMJD2A and monomethylated H3K36 peptide | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [7] |
| PDB Sequence |
ASESETLNPS
11 ARIMTFYPTM21 EEFRNFSRYI31 AYIESQGAHR41 AGLAKVVPPK51 EWKPRASYDD 61 IDDLVIPAPI71 QQLVTGQSGL81 FTQYNIQKKA91 MTVREFRKIA101 NSDKYCTPRY 111 SEFEELERKY121 WKNLTFNPPI131 YGADVNGTLY141 EKHVDEWNIG151 RLRTILDLVE 161 KESGITIEGV171 NTPYLYFGMW181 KTSFAWHTED191 MDLYSINYLH201 FGEPKSWYSV 211 PPEHGKRLER221 LAKGFFPGSA231 QSCEAFLRHK241 MTLISPLMLK251 KYGIPFDKVT 261 QEAGEFMITF271 PYGYHAGFNH281 GFNCAESTNF291 ATRRWIEYGK301 QAVLCSCRKD 311 MVKISMDVFV321 RKFQPERYKL331 WKAGKDNTVI341 DHTLPTP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OGA or .OGA2 or .OGA3 or :3OGA;style chemicals stick;color identity;select .A:132 or .A:177 or .A:184 or .A:185 or .A:188 or .A:190 or .A:196 or .A:197 or .A:198 or .A:206 or .A:208 or .A:270 or .A:276 or .A:288; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates. Epigenetics. 2014 Dec;9(12):1596-603. | ||||
| REF 2 | Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature. 2007 Jul 5;448(7149):87-91. | ||||
| REF 3 | Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26. FEBS Lett. 2018 Oct;592(19):3264-3273. | ||||
| REF 4 | Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases. Nat Commun. 2016 Jun 23;7:11974. | ||||
| REF 5 | Highly selective inhibition of histone demethylases by de novo macrocyclic peptides. Nat Commun. 2017 Apr 6;8:14773. | ||||
| REF 6 | Structure-based design of selective, histone substrate-based inhibitors of histone lysine demethylases 4 (KDM4) subfamily | ||||
| REF 7 | Structural basis of the recognition of a methylated histone tail by JMJD2A. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10818-23. | ||||
| REF 8 | Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase. Nat Struct Mol Biol. 2007 Aug;14(8):689-95. | ||||
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