Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T18904 | Target Info | |||
| Target Name | Lysine-specific demethylase 4A (KDM4A) | ||||
| Synonyms | KIAA0677; Jumonji domain-containing protein 2A; JmjC domain-containing histone demethylation protein 3A; JMJD2A; JMJD2; JHDM3A | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | KDM4A | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Fumaric acid | Ligand Info | |||
| Canonical SMILES | C(=CC(=O)O)C(=O)O | ||||
| InChI | 1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+ | ||||
| InChIKey | VZCYOOQTPOCHFL-OWOJBTEDSA-N | ||||
| PubChem Compound ID | 444972 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 5FYC Crystal structure of human JMJD2A in complex with succinate | ||||||
| Method | X-ray diffraction | Resolution | 2.26 Å | Mutation | No | [1] |
| PDB Sequence |
LNPSARIMTF
17 YPTMEEFRNF27 SRYIAYIESQ37 GAHRAGLAKV47 VPPKEWKPRA57 SYDDIDDLVI 67 PAPIQQLVTG77 QSGLFTQYNI87 QKKAMTVREF97 RKIANSDKYC107 TPRYSEFEEL 117 ERKYWKNLTF127 NPPIYGADVN137 GTLYEKHVDE147 WNIGRLRTIL157 DLVEKESGIT 167 IEGVNTPYLY177 FGMWKTSFAW187 HTEDMDLYSI197 NYLHFGEPKS207 WYSVPPEHGK 217 RLERLAKGFF227 PGSAQSCEAF237 LRHKMTLISP247 LMLKKYGIPF257 DKVTQEAGEF 267 MITFPYGYHA277 GFNHGFNCAE287 STNFATRRWI297 EYGKQAVLCS307 CRKDMVKISM 317 DVFVRKFQPE327 RYKLWKAGKD337 NTVIDHTLPT347 PEAAEF
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| PDB ID: 5FYH Crystal structure of human JMJD2A in complex with fumarate | ||||||
| Method | X-ray diffraction | Resolution | 2.35 Å | Mutation | No | [2] |
| PDB Sequence |
ESETLNPSAR
13 IMTFYPTMEE23 FRNFSRYIAY33 IESQGAHRAG43 LAKVVPPKEW53 KPRASYDDID 63 DLVIPAPIQQ73 LVTGQSGLFT83 QYNIQKKAMT93 VREFRKIANS103 DKYCTPRYSE 113 FEELERKYWK123 NLTFNPPIYG133 ADVNGTLYEK143 HVDEWNIGRL153 RTILDLVEKE 163 SGITIEGVNT173 PYLYFGMWKT183 SFAWHTEDMD193 LYSINYLHFG203 EPKSWYSVPP 213 EHGKRLERLA223 KGFFPGSAQS233 CEAFLRHKMT243 LISPLMLKKY253 GIPFDKVTQE 263 AGEFMITFPY273 GYHAGFNHGF283 NCAESTNFAT293 RRWIEYGKQA303 VLCSCRKDMV 313 KISMDVFVRK323 FQPERYKLWK333 AGKDNTVIDH343 TLPTPEAAEF353 L |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal Structure of Human Jmjd2A in Complex with Succinate | ||||
| REF 2 | Crystal Structure of Human Jmjd2A in Complex with Fumarate | ||||
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