Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T15795 | Target Info | |||
| Target Name | TWIK-related acid-sensitive potassium channel 1 (TASK1) | ||||
| Synonyms | Two pore potassium channel KT3.1; Two pore K(+) channel KT3.1; TWIK-related acid-sensitive K(+) channel 1; Acid-sensitive potassium channel protein TASK-1 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | KCNK3 | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Decyl-beta-D-maltopyranoside | Ligand Info | |||
| Canonical SMILES | CCCCCCCCCCOC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)CO)O)O)O)O)O | ||||
| InChI | 1S/C22H42O11/c1-2-3-4-5-6-7-8-9-10-30-21-19(29)17(27)20(14(12-24)32-21)33-22-18(28)16(26)15(25)13(11-23)31-22/h13-29H,2-12H2,1H3/t13-,14-,15-,16+,17-,18-,19-,20-,21-,22-/m1/s1 | ||||
| InChIKey | WOQQAWHSKSSAGF-WXFJLFHKSA-N | ||||
| PubChem Compound ID | 5288728 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6RV3 Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 1000493 | ||||||
| Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | No | [1] |
| PDB Sequence |
MKRQNVRTLA
10 LIVCTFTYLL20 VGAAVFDALE30 SEPELIERQR40 LELRQQELRA50 RYNLSQGGYE 60 ELERVVLRLK70 PHKAGVQWRF80 AGSFYFAITV90 ITTIGYGHAA100 PSTDGGKVFC 110 MFYALLGIPL120 TLVMFQSLGE130 RINTLVRYLL140 HRAKKGLGAD153 VSMANMVLIG 163 FFSCISTLCI173 GAAAFSHYEH183 WTFFQAYYYC193 FITLTTIGFG203 DYVALQKDQA 213 LQTQPQYVAF223 SFVYILTGLT233 VIGAFLNLVV243 LRFMTMNAED253 EKRDAENL |
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| PDB ID: 6RV2 Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation | ||||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | No | [1] |
| PDB Sequence |
MKRQNVRTLA
10 LIVCTFTYLL20 VGAAVFDALE30 SEPELIERQR40 LELRQQELRA50 RYNLSQGGYE 60 ELERVVLRLK70 PHKAGVQWRF80 AGSFYFAITV90 ITTIGYGHAA100 PSTDGGKVFC 110 MFYALLGIPL120 TLVMFQSLGE130 RINTLVRYLL140 HRAKKGLGAD153 VSMANMVLIG 163 FFSCISTLCI173 GAAAFSHYEH183 WTFFQAYYYC193 FITLTTIGFG203 DYVALQKDQA 213 LQTQPQYVAF223 SFVYILTGLT233 VIGAFLNLVV243 LRFMTMNAED253 EKRD |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A lower X-gate in TASK channels traps inhibitors within the vestibule. Nature. 2020 Jun;582(7812):443-447. | ||||
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