Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T14558 | Target Info | |||
| Target Name | Tryptase alpha/beta-1 (Tryptase) | ||||
| Synonyms | Tryptase-1; Tryptase alpha-1; Tryptase I; TPSB1; TPS2; TPS1 | ||||
| Target Type | Successful Target | ||||
| Gene Name | TPSAB1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | (R,R)-2,3-butanediol | Ligand Info | |||
| Canonical SMILES | CC(C(C)O)O | ||||
| InChI | 1S/C4H10O2/c1-3(5)4(2)6/h3-6H,1-2H3/t3-,4-/m1/s1 | ||||
| InChIKey | OWBTYPJTUOEWEK-QWWZWVQMSA-N | ||||
| PubChem Compound ID | 225936 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 2F9N Crystal Structure of the Recombinant Human Alpha I Tryptase Mutant K192Q/D216G in Complex with Leupeptin | ||||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | Yes | [1] |
| PDB Sequence |
IVGGQEAPRS
25 KWPWQVSLRV35 RDRYWMHFCG43 GSLIHPQWVL53 TAAHCVGPDV60C KDLATLRVQL 68 REQHLYYQDQ81 LLPVSRIIVH91 PQFYIIQTGA101 DIALLELEEP111 VNISSRVHTV 121 MLPPASETFP131 PGMPCWVTGW141 GDVDNDEPLP152 PPFPLKQVKV160 PIMENHICDA 170 KYHLGAYTGD173G DVRIIRDDML181 CAGNSQRDSC191 QGDSGGPLVC201 KVNGTWLQAG 211 VVSWGEGCAQ221A PNRPGIYTRV231 TYYLDWIHHY241 VPK
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| PDB ID: 2F9P Crystal Structure of the Recombinant Human Alpha I Tryptase Mutant D216G in Complex with Leupeptin | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [1] |
| PDB Sequence |
IVGGQEAPRS
25 KWPWQVSLRV35 RDRYWMHFCG43 GSLIHPQWVL53 TAAHCVGPDV60C KDLATLRVQL 68 REQHLYYQDQ81 LLPVSRIIVH91 PQFYIIQTGA101 DIALLELEEP111 VNISSRVHTV 121 MLPPASETFP131 PGMPCWVTGW141 GDVDNDEPLP152 PPFPLKQVKV160 PIMENHICDA 170 KYHLGAYTGD173G DVRIIRDDML181 CAGNSQRDSC191 KGDSGGPLVC201 KVNGTWLQAG 211 VVSWGEGCAQ221A PNRPGIYTRV231 TYYLDWIHHY241 VPK
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha-->beta-tryptase transition. J Mol Biol. 2006 Mar 17;357(1):195-209. | ||||
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