Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T12499 Target Info
Target Name LCK tyrosine protein kinase (LCK)
Synonyms p56-LCK; Tyrosine-protein kinase Lck; T cell-specific protein-tyrosine kinase; Proto-oncogene tyrosine-protein kinase LCK; Proto-oncogene Lck; Protein YT16; Lymphocyte cell-specific protein-tyrosine kinase; Leukocyte C-terminal Src kinase; LSK; LCK p59-Fyn; LCK Protooncogene Syn
Target Type Successful Target
Gene Name LCK
Biochemical Class Kinase
UniProt ID
LCK_HUMAN
Ligand General Information  Top
Ligand Name Staurosporine Ligand Info
Canonical SMILES CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
InChI 1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
InChIKey HKSZLNNOFSGOKW-FYTWVXJKSA-N
PubChem Compound ID 44259
Drug Binding Sites of Target  Top
PDB ID: 1QPD      STRUCTURAL ANALYSIS OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH NON-SELECTIVE AND SRC FAMILY SELECTIVE KINASE INHIBITORS
Method X-ray diffraction Resolution 2.00 Å Mutation Yes [1]
PDB Sequence
KPWWEDAWEV
240
PRETLKLVER
250
LGAGQAGEVW
260
MGYYNGHTKV
270
AVKSLKQGSM
280

SPDAFLAEAN
290
LMKQLQHQRL
300
VRLYAVVTQE
310
PIYIITEYME
320
NGSLVDFLKT
330

PSGIKLTINK
340
LLDMAAQIAE
350
GMAFIEERNY
360
IHRDLRAANI
370
LVSDTLSCKI
380

ADFGLARLIE
390
DAETAREGAK
401
FPIKWTAPEA
411
INYGTFTIKS
421
DVWSFGILLT
431

EIVTHGRIPY
441
PGMTNPEVIQ
451
NLERGYRMVR
461
PDNCPEELYQ
471
LMRLCWKERP
481

EDRPTFDYLR
491
SVLEDFFTAT
501
E
Residue
Distance (Å)
LEU251
3.359
GLY252
3.750
VAL259
3.747
ALA271
3.180
LYS273
3.648
GLU288
4.590
VAL301
4.343
THR316
3.256
GLU317
2.924
TYR318
3.482
MET319
2.763
Residue
Distance (Å)
GLU320
4.117
ASN321
4.655
GLY322
3.429
SER323
2.864
ASP326
3.022
ALA368
3.195
ASN369
4.033
LEU371
3.370
ALA381
4.897
ASP382
4.034
PDB ID: 1QPJ      CRYSTAL STRUCTURE OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH STAUROSPORINE.
Method X-ray diffraction Resolution 2.20 Å Mutation Yes [1]
PDB Sequence
DEWEVPRETL
245
KLVERLGAGQ
255
FGEVWMGYYN
265
GHTKVAVKSL
275
KQGSMSPDAF
285

LAEANLMKQL
295
QHQRLVRLYA
305
VVTQEPIYII
315
TEYMENGSLV
325
DFLKTPSGIK
335

LTINKLLDMA
345
AQIAEGMAFI
355
EERNYIHRDL
365
RAANILVSDT
375
LSCKIADFGL
385

ARLIEDNETA
396
REGAKFPIKW
406
TAPEAINYGT
416
FTIKSDVWSF
426
GILLTEIVTH
436

GRIPYPGMTN
446
PEVIQNLERG
456
YRMVRPDNCP
466
EELYQLMRLC
476
WKERPEDRPT
486

FDYLRSVLED
496
FFTAT
Residue
Distance (Å)
LEU251
3.652
GLY252
3.483
ALA253
4.127
VAL259
3.769
ALA271
3.227
LYS273
2.304
GLU288
3.807
VAL301
4.358
THR316
2.721
GLU317
1.954
TYR318
3.470
MET319
1.922
Residue
Distance (Å)
GLU320
4.720
ASN321
4.696
GLY322
3.184
SER323
2.065
VAL325
4.708
ASP326
3.809
ALA368
2.323
ASN369
3.752
LEU371
3.502
ALA381
4.397
ASP382
3.558
PHE383
4.800
References  Top
REF 1 Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors. Structure. 1999 Jun 15;7(6):651-61.

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