Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T12241 | Target Info | |||
| Target Name | Cystathionine gamma-lyase (CTH) | ||||
| Synonyms | Gamma-cystathionase; Cysteine-protein sulfhydrase | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | CTH | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Pyridoxal phosphate | Ligand Info | |||
| Canonical SMILES | CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O | ||||
| InChI | 1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14) | ||||
| InChIKey | NGVDGCNFYWLIFO-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 1051 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 3COG Crystal structure of human cystathionase (Cystathionine gamma lyase) in complex with DL-propargylglycine | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [1] |
| PDB Sequence |
GFLPHFQHFA
19 TQAIHVGQDP29 EQWTSRAVVP39 PISLSTTFKQ49 GNPTRNCLEK73 AVAALDGAKY 83 CLAFASGLAA93 TVTITHLLKA103 GDQIICMDDV113 YGGTNRYFRQ123 VASEFGLKIS 133 FVDCSKIKLL143 EAAITPETKL153 VWIETPTNPT163 QKVIDIEGCA173 HIVHKHGDII 183 LVVDNTFMSP193 YFQRPLALGA203 DISMYSATKY213 MNGHSDVVMG223 LVSVNCESLH 233 NRLRFLQNSL243 GAVPSPIDCY253 LCNRGLKTLH263 VRMEKHFKNG273 MAVAQFLESN 283 PWVEKVIYPG293 LPSHPQHELV303 KRQCTGCTGM313 VTFYIKGTLQ323 HAEIFLKNLK 333 LFTLAESLGG343 FESLAELPAI353 MTHASVLKND363 RDVLGISDTL373 IRLSVGLEDE 383 EDLLEDLDQA393 LKAAHP
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| PDB ID: 2NMP Crystal structure of human Cystathionine gamma lyase | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [1] |
| PDB Sequence |
GFLPHFQHFA
19 TQAIHVGQDP29 EQWTSRAVVP39 PISLSTTFKQ49 GNPTRNCLEK73 AVAALDGAKY 83 CLAFASGLAA93 TVTITHLLKA103 GDQIICMDDV113 YGGTNRYFRQ123 VASEFGLKIS 133 FVDCSKIKLL143 EAAITPETKL153 VWIETPTNPT163 QKVIDIEGCA173 HIVHKHGDII 183 LVVDNTFMSP193 YFQRPLALGA203 DISMYSATKY213 MNGHSDVVMG223 LVSVNCESLH 233 NRLRFLQNSL243 GAVPSPIDCY253 LCNRGLKTLH263 VRMEKHFKNG273 MAVAQFLESN 283 PWVEKVIYPG293 LPSHPQHELV303 KRQCTGCTGM313 VTFYIKGTLQ323 HAEIFLKNLK 333 LFTLAESLGG343 FESLAELPAI353 MTHASVLKND363 RDVLGISDTL373 IRLSVGLEDE 383 EDLLEDLDQA393 LKAAHP
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S. J Biol Chem. 2009 Jan 30;284(5):3076-3085. | ||||
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