Target Binding Site Detail
Target General Information | Top | ||||
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Target ID | T05387 | Target Info | |||
Target Name | Tissue transglutaminase (TG2) | ||||
Synonyms | Transglutaminase-2; Transglutaminase H; Transglutaminase C; Transglutaminase 2; Tranglutaminase 2; TTg; TGase-H; TGase-2; TGase H; TGase C; TGC; TG(C)Protein-glutamine gamma-glutamyltransferase; TG(C); Protein-glutamine gamma-glutamyltransferase 2 | ||||
Target Type | Clinical trial Target | ||||
Gene Name | TGM2 | ||||
Biochemical Class | Acyltransferase | ||||
UniProt ID |
Ligand General Information | Top | ||||
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Ligand Name | Guanosine-5'-Triphosphate | Ligand Info | |||
Canonical SMILES | C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N | ||||
InChI | 1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1 | ||||
InChIKey | XKMLYUALXHKNFT-UUOKFMHZSA-N | ||||
PubChem Compound ID | 135398633 |
Drug Binding Sites of Target | Top | |||||
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PDB ID: 6A8P Transglutaminase 2 mutant G224V in complex with GTP | ||||||
Method | X-ray diffraction | Resolution | 2.54 Å | Mutation | No | [1] |
PDB Sequence |
MAEELVLERC
10 DLELETNGRD20 HHTADLCREK30 LVVRRGQPFW40 LTLHFEGRNY50 EASVDSLTFS 60 VVTGPAPSQE70 AGTKARFPLR80 DAVEEGDWTA90 TVVDQQDCTL100 SLQLTTPANA 110 PIGLYRLSLE120 ASTGYQGSSF130 VLGHFILLFN140 AWCPADAVYL150 DSEEERQEYV 160 LTQQGFIYQG170 SAKFIKNIPW180 NFGQFEDGIL190 DICLILLDVN200 PKFLKNAGRD 210 CSRRSSPVYV220 GRVVSGMVNC230 NDDQGVLLGR240 WDNNYGDGVS250 PMSWIGSVDI 260 LRRWKNHGCQ270 RVKYGQCWVF280 AAVACTVLRC290 LGIPTRVVTN300 YNSAHDQNSN 310 LLIEYFRNEF320 GEIQGDKSEM330 IWNFHCWVES340 WMTRPDLQPG350 YEGWQALDPT 360 PQEKSEGTYC370 CGPVPVRAIK380 EGDLSTKYDA390 PFVFAEVNAD400 VVDWIQQDDG 410 SVHKSINRSL420 IVGLKISTKS430 VGRDEREDIT440 HTYKYPEGSS450 EEREAFTRAN 460 HLNTGMAMRI477 RVGQSMNMGS487 DFDVFAHITN497 NTAEEYVCRL507 LLCARTVSYN 517 GILGPECGTK527 YLLNLNLEPF537 SEKSVPLCIL547 YEKYRDCLTE557 SNLIKVRALL 567 VEPVINSYLL577 AERDLYLENP587 EIKIRILGEP597 KQKRKLVAEV607 SLQNPLPVAL 617 EGCTFTVEGA627 GLTEEQKTVE637 IPDPVEAGEE647 VKVRMDLLPL657 HMGLHKLVVN 667 FESDKLKAVK677 GFRNVIIGPA687 L
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PDB ID: 4PYG Transglutaminase2 complexed with GTP | ||||||
Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | No | [2] |
PDB Sequence |
ELVLERCDLE
13 LETNGRDHHT23 ADLCREKLVV33 RRGQPFWLTL43 HFEGRNYEAS53 VDSLTFSVVT 63 GPAPSQEAGT73 KARFPLRDAV83 EEGDWTATVV93 DQQDCTLSLQ103 LTTPANAPIG 113 LYRLSLEAST123 GYQGSSFVLG133 HFILLFNAWC143 PADAVYLDSE153 EERQEYVLTQ 163 QGFIYQGSAK173 FIKNIPWNFG183 QFEDGILDIC193 LILLDVNPKF203 LKNAGRDCSR 213 RSSPVYVGRV223 VSGMVNCNDD233 QGVLLGRWDN243 NYGDGVSPMS253 WIGSVDILRR 263 WKNHGCQRVK273 YGQCWVFAAV283 ACTVLRCLGI293 PTRVVTNYNS303 AHDQNSNLLI 313 EYFRNEFGEI323 QGDKSEMIWN333 FHCWVESWMT343 RPDLQPGYEG353 WQALDPTPQE 363 KSEGTYCCGP373 VPVRAIKEGD383 LSTKYDAPFV393 FAEVNADVVD403 WIQQDDGSVH 413 KSINRSLIVG423 LKISTKSVGR433 DEREDITHTY443 KYPEGSSEER453 EAFTRANHLN 463 KLAEKEETGM473 AMRIRVGQSM483 NMGSDFDVFA493 HITNNTAEEY503 VCRLLLCART 513 VSYNGILGPE523 CGTKYLLNLN533 LEPFSEKSVP543 LCILYEKYRD553 CLTESNLIKV 563 RALLVEPVIN573 SYLLAERDLY583 LENPEIKIRI593 LGEPKQKRKL603 VAEVSLQNPL 613 PVALEGCTFT623 VEGAGLTEEQ633 KTVEIPDPVE643 AGEEVKVRMD653 LLPLHMGLHK 663 LVVNFESDKL673 KAVKGFRNVI683 IGPAL
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References | Top | ||||
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REF 1 | Structure of natural variant transglutaminase 2 reveals molecular basis of gaining stability and higher activity. PLoS One. 2018 Oct 15;13(10):e0204707. | ||||
REF 2 | Crystal structure of transglutaminase 2 with GTP complex and amino acid sequence evidence of evolution of GTP binding site. PLoS One. 2014 Sep 5;9(9):e107005. |
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