Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T03691 | Target Info | |||
| Target Name | Leukotriene A-4 hydrolase (LTA4H) | ||||
| Synonyms | Leukotriene A4 hydrolase; Leukotriene A(4)Leukotriene A-4 hydrolase hydrolase; Leukotriene A(4) hydrolase; LTA4; LTA-H; LTA-4hydrolase; LTA-4 hydrolase | ||||
| Target Type | Successful Target | ||||
| Gene Name | LTA4H | ||||
| Biochemical Class | Ether bond hydrolase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | 1-{4-Oxo-4-[(2s)-Pyrrolidin-2-Yl]butanoyl}-L-Proline | Ligand Info | |||
| Canonical SMILES | C1CC(NC1)C(=O)CCC(=O)N2CCCC2C(=O)O | ||||
| InChI | 1S/C13H20N2O4/c16-11(9-3-1-7-14-9)5-6-12(17)15-8-2-4-10(15)13(18)19/h9-10,14H,1-8H2,(H,18,19)/t9-,10-/m0/s1 | ||||
| InChIKey | FCVBOVVXXBUFFZ-UWVGGRQHSA-N | ||||
| PubChem Compound ID | 73167569 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 4MKT Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue and 4-(4-benzylphenyl)thiazol-2-amine | ||||||
| Method | X-ray diffraction | Resolution | 1.62 Å | Mutation | No | [1] |
| PDB Sequence |
IVDTCSLASP
12 ASVCRTKHLH22 LRCSVDFTRR32 TLTGTAALTV42 QSQEDNLRSL52 VLDTKDLTIE 62 KVVINGQEVK72 YALGERQSYK82 GSPMEISLPI92 ALSKNQEIVI102 EISFETSPKS 112 SALQWLTPEQ122 TSGKEHPYLF132 SQCQAIHCRA142 ILPCQDTPSV152 KLTYTAEVSV 162 PKELVALMSA172 IRDGETPDPE182 DPSRKIYKFI192 QKVPIPCYLI202 ALVVGALESR 212 QIGPRTLVWS222 EKEQVEKSAY232 EFSETESMLK242 IAEDLGGPYV252 WGQYDLLVLP 262 PSFPYGGMEN272 PCLTFVTPTL282 LAGDKSLSNV292 IAHEISHSWT302 GNLVTNKTWD 312 HFWLNEGHTV322 YLERHICGRL332 FGEKFRHFNA342 LGGWGELQNS352 VKTFGETHPF 362 TKLVVDLTDI372 DPDVAYSSVP382 YEKGFALLFY392 LEQLLGGPEI402 FLGFLKAYVE 412 KFSYKSITTD422 DWKDFLYSYF432 KDKVDVLNQV442 DWNAWLYSPG452 LPPIKPNYDM 462 TLTNACIALS472 QRWITAKEDD482 LNSFNATDLK492 DLSSHQLNEF502 LAQTLQRAPL 512 PLGHIKRMQE522 VYNFNAINNS532 EIRFRWLRLC542 IQSKWEDAIP552 LALKMATEQG 562 RMKFTRPLFK572 DLAAFDKSHD582 QAVRTYQEHK592 ASMHPVTAML602 VGKDLKVD |
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| PDB ID: 4MS6 Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue | ||||||
| Method | X-ray diffraction | Resolution | 1.72 Å | Mutation | No | [1] |
| PDB Sequence |
IVDTCSLASP
12 ASVCRTKHLH22 LRCSVDFTRR32 TLTGTAALTV42 QSQEDNLRSL52 VLDTKDLTIE 62 KVVINGQEVK72 YALGERQSYK82 GSPMEISLPI92 ALSKNQEIVI102 EISFETSPKS 112 SALQWLTPEQ122 TSGKEHPYLF132 SQCQAIHCRA142 ILPCQDTPSV152 KLTYTAEVSV 162 PKELVALMSA172 IRDGETPDPE182 DPSRKIYKFI192 QKVPIPCYLI202 ALVVGALESR 212 QIGPRTLVWS222 EKEQVEKSAY232 EFSETESMLK242 IAEDLGGPYV252 WGQYDLLVLP 262 PSFPYGGMEN272 PCLTFVTPTL282 LAGDKSLSNV292 IAHEISHSWT302 GNLVTNKTWD 312 HFWLNEGHTV322 YLERHICGRL332 FGEKFRHFNA342 LGGWGELQNS352 VKTFGETHPF 362 TKLVVDLTDI372 DPDVAYSSVP382 YEKGFALLFY392 LEQLLGGPEI402 FLGFLKAYVE 412 KFSYKSITTD422 DWKDFLYSYF432 KDKVDVLNQV442 DWNAWLYSPG452 LPPIKPNYDM 462 TLTNACIALS472 QRWITAKEDD482 LNSFNATDLK492 DLSSHQLNEF502 LAQTLQRAPL 512 PLGHIKRMQE522 VYNFNAINNS532 EIRFRWLRLC542 IQSKWEDAIP552 LALKMATEQG 562 RMKFTRPLFK572 DLAAFDKSHD582 QAVRTYQEHK592 ASMHPVTAML602 VGKDLKVD |
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| PDB ID: 7LLQ Substrate-dependent divergence of leukotriene A4 hydrolase aminopeptidase activity | ||||||
| Method | X-ray diffraction | Resolution | 2.85 Å | Mutation | No | [2] |
| PDB Sequence |
IVDTCSLASP
12 ASVCRTKHLH22 LRCSVDFTRR32 TLTGTAALTV42 QSQEDNLRSL52 VLDTKDLTIE 62 KVVINGQEVK72 YALGERQSYK82 GSPMEISLPI92 ALSKNQEIVI102 EISFETSPKS 112 SALQWLTPEQ122 TSGKEHPYLF132 SQCQAIHCRA142 ILPCQDTPSV152 KLTYTAEVSV 162 PKELVALMSA172 IRDGETPDPE182 DPSRKIYKFI192 QKVPIPCYLI202 ALVVGALESR 212 QIGPRTLVWS222 EKEQVEKSAY232 EFSETESMLK242 IAEDLGGPYV252 WGQYDLLVLP 262 PSFPYGGMEN272 PCLTFVTPTL282 LAGDKSLSNV292 IAHEISHSWT302 GNLVTNKTWD 312 HFWLNEGHTV322 YLERHICGRL332 FGEKFRHFNA342 LGGWGELQNS352 VKTFGETHPF 362 TKLVVDLTDI372 DPDVAYSSVP382 YEKGFALLFY392 LEQLLGGPEI402 FLGFLKAYVE 412 KFSYKSITTD422 DWKDFLYSYF432 KDKVDVLNQV442 DWNAWLYSPG452 LPPIKPNYDM 462 TLTNACIALS472 QRWITAKEDD482 LNSFNATDLK492 DLSSHQLNEF502 LAQTLQRAPL 512 PLGHIKRMQE522 VYNFNAINNS532 EIRFRWLRLC542 IQSKWEDAIP552 LALKMATEQG 562 RMKFTRPLFK572 DLAAFDKSHD582 QAVRTYQEHK592 ASMHPVTAML602 VGKDLKVD |
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GLN134
4.801
GLN136
2.896
PRO266
4.614
TYR267
2.954
GLY268
2.860
GLY269
2.478
MET270
4.123
GLU271
2.324
VAL292
4.646
HIS295
2.364
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4227-32. | ||||
| REF 2 | Substrate-dependent modulation of the leukotriene A(4) hydrolase aminopeptidase activity and effect in a murine model of acute lung inflammation. Sci Rep. 2022 Jun 8;12(1):9443. | ||||
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