Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T01865 | Target Info | |||
| Target Name | Plasmodium Hexose transporter 1 (Malaria ht1) | ||||
| Synonyms | ht1; Putative sugar transporter; Hexose transporter | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | Malaria ht1 | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Beta-D-Glucose | Ligand Info | |||
| Canonical SMILES | C(C1C(C(C(C(O1)O)O)O)O)O | ||||
| InChI | 1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1 | ||||
| InChIKey | WQZGKKKJIJFFOK-VFUOTHLCSA-N | ||||
| PubChem Compound ID | 64689 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6M20 Crystal structure of Plasmodium falciparum hexose transporter PfHT1 bound with glucose | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [1] |
| PDB Sequence |
FSTSFKYVLS
32 ACIASFIFGY42 QVSVLNTIKN52 FIVVEFEWCK62 GEKDRLNCSN72 NTIQSSFLLA 82 SVFIGAVLGC92 GFSGYLVQFG102 RRLSLLIIYN112 FFFLVSILTS122 ITHHFHTILF 132 ARLLSGFGIG142 LVTVSVPMYI152 SEMTHKDKKG162 AYGVMHQLFI172 TFGIFVAVML 182 GLAMGEGPKA192 DSTEPLTSFA202 KLWWRLMFLF212 PSVISLIGIL222 ALVVFFKEET 232 PYFLFEKGRI242 EESKNILKKI252 YETDNVDEPL262 NAIKEAVEQN272 ESAKKNSLSL 282 LSALKIPSYR292 YVIILGCLLS302 GLQQFTGINV312 LVSNSNELYK322 EFLDSHLITI 332 LSVVMTAVNF342 LMTFPAIYIV352 EKLGRKTLLL362 WGCVGVLVAY372 LPTAIANEIN 382 RNSNFVKILS392 IVATFVMIIS402 FAVSYGPVLW412 IYLHEMFPSE422 IKDSAASLAS 432 LVNWVCAIIV442 VFPSDIIIKK452 SPSILFIVFS462 VMSILTFFFI472 FFFIKETKGG 482 EIGTSPYITM492 EERQKH
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| PDB ID: 6RW3 The molecular basis for sugar import in malaria parasites. | ||||||
| Method | X-ray diffraction | Resolution | 3.65 Å | Mutation | No | [2] |
| PDB Sequence |
FFSTSFKYVL
31 SACIASFIFG41 YQVSVLNTIK51 NFIVVEFECS71 NNTIQSSFLL81 ASVFIGAVLG 91 CGFSGYLVQF101 GRRLSLLIIY111 NFFFLVSILT121 SITHHFHTIL131 FARLLSGFGI 141 GLVTVSVPMY151 ISEMTHKDKK161 GAYGVMHQLF171 ITFGIFVAVM181 LGLAMGETSF 201 AKLWWRLMFL211 FPSVISLIGI221 LALVVFFKEE231 TPYFLFEKGR241 IEESKNILKK 251 IYETDNVDEP261 LNAIKEAVEQ271 NESAKKNSLS281 LLSALKIPSY291 RYVIILGCLL 301 SGLQQFTGIN311 VLVSNSNELY321 KEFLDSHLIT331 ILSVVMTAVN341 FLMTFPAIYI 351 VEKLGRKTLL361 LWGCVGVLVA371 YLPTAIANEN386 FVKILSIVAT396 FVMIISFAVS 406 YGPVLWIYLH416 EMFPSEIKDS426 AASLASLVNW436 VCAIIVVFPS446 DIIIKKSPSI 456 LFIVFSVMSI466 LTFFFIFFFI476 KETKGGE
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum. Cell. 2020 Oct 1;183(1):258-268.e12. | ||||
| REF 2 | The molecular basis for sugar import in malaria parasites. Nature. 2020 Feb;578(7794):321-325. | ||||
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